DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and boi

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001096868.3	Gene:	boi / 31229	FlyBaseID:	FBgn0040388	Length:	1105	Species:	Drosophila melanogaster

Alignment Length:	909	Identity:	204/909 - (22%)
Similarity:	314/909 - (34%)	Gaps:	268/909 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VFLALLLCSC--------SLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVAD- 66
            |.|.:|:.:|        |...:......:.|..|:..|  .|.|..::..|     |.:|..|
  Fly     8 VVLLVLMTTCIYTLQASDSNSSVATTLGVLFERAPESAV--APKGDEVVFEC-----ELNLKPDR 65

  Fly    67 LQWKDNRNNTILP----KPNGRNQPPMYTETLPGESLALMI-TSLSVEMGGKYYCTASY-----A 121
            |:|:..|.::..|    :|:..     |..|...:.||..: ..:|.:..|.|.|.|.|     |
  Fly    66 LEWRFRRGDSSEPYLYLRPSAG-----YNVTSGSDGLAWRLRIYVSAQTAGDYQCVAWYGPGALA 125

  Fly   122 NTEILEKGVTIKTYV---------AITWTNAPENQYPTLGQDYVVMC-EVKADPNPTIDWLRNGD 176
            :|......|:|...|         :|.|:.||:|       ..::.| .|.::|.....:.|||.
  Fly   126 STPARLALVSIALDVGQGSMGARSSIRWSVAPKN-------CLLIRCGSVISNPPAIWSFYRNGK 183

  Fly   177 PIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGE--LLERTIRVEV---------FIQP 230
            .: ..::........|::..|...|.|.|:|.|....||:  .|.:||.:.|         |:|.
  Fly   184 KL-PQSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGDELRLPQTIELRVDYTDRTPPYFLQR 247

  Fly   231 EIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGL---VTISSV 292
            .    |....|..|:.....|...|.|.|.:.|    :..||.   ....|..|.|   :.|:.|
  Fly   248 P----PIEYSARPGETVVLECPGVGSPRPRVIW----SSPNVV---EIYNNRSTILSYGLQITDV 301

  Fly   293 SQDDYGTYTCLAKNR-AGVVDQKTKLNVLVRPQIYELYNVTGARTKE---IAITCRAKGRPAPAI 353
            ..:|.|:|.|:..|. |..:|...||:||.||.|  |.......|.|   :.:.|.|.|.|.|.|
  Fly   302 KPEDQGSYICMLDNGIAPPIDHTIKLSVLQRPTI--LRGPAATLTNESNPLLLDCSASGNPQPDI 364

  Fly   354 TFRRWGTQEEYTNGQQ-DDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAY 417
               .|     ..||:. ..||..:::          ..:|::...::...|:.||.|:|...:..
  Fly   365 ---YW-----LINGEDATKDPEAVVD----------NRSLQLKRVQKRHAGVVQCFAKNILGETS 411

  Fly   418 KTGHITVE----FAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNL 478
            :...:.|.    ...|...:.|:|   .|...::|   ..||..:.:     .|.|.|
  Fly   412 EGNILRVNPLEITGEDDEPLGEVP---VWPVHESN---TGMGTSSTS-----GGSKNK------- 458

  Fly   479 KIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTF 543
                                 ||.:              :.|.:.||       ||:...|.::.
  Fly   459 ---------------------SGRR--------------KFKASMVP-------PSRPNVTRLSD 481

  Fly   544 DIRGPSTEL--------GLPILAYSVQYK-----EALNPDWSTAY----------------NRSW 579
            :    |..|        ||.|..:.|||:     :....:|.|..                |..|
  Fly   482 E----SVMLRWSVPQNSGLQITFFKVQYRMLGDGKNRRKNWQTTSDNIPYGNAHGSGPGQGNSHW 542

  Fly   580 ---SPDSPY-----------IVEGLRPQTEYSFRFAA---RNQVGLGNWGVN--QQQSTPRRSAP 625
               :.|..|           .|.||.....|.||..|   .|....||..:.  .|..|.:.:.
  Fly   543 RARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKEGNTSLKFFLQNGTSKSNL- 606

  Fly   626 EEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSC 690
              |.|....|:...|..||:     |:.|   |.:...|.||.|...|.|....:      |...
  Fly   607 --PVPELREVETLSESAVVL-----HWSL---VSSTQNEDIDGYYAYYRPADSAA------EYLK 655

  Fly   691 NTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAA-- 753
            .||:...:.||::..|...|.|..:|::.|:...|..::|....||     :..|:...|||.
  Fly   656 ATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTR-----KTHEQPASSSATPV 715

  Fly   754 ----------------IVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRKAKRSPSEIDDEAK 801
                            |.|.|.||:|||  :..|:.|          :|.| :|..|:.:||.|
  Fly   716 PANKAVEQHQNSLYPLIAGAAGGGILLL--IASLVVC----------LCLK-RRENSQPEDENK 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	25/104 (24%)
		IG_like	144..226	CDD:214653	20/84 (24%)
		IGc2	152..209	CDD:197706	12/57 (21%)
		I-set	230..319	CDD:254352	24/92 (26%)
		IGc2	243..309	CDD:197706	18/69 (26%)
		IG_like	330..424	CDD:214653	19/97 (20%)
		IGc2	339..412	CDD:197706	16/73 (22%)
		Ig	447..518	CDD:143165	8/70 (11%)
		fn3	534..611	CDD:278470	25/122 (20%)
		FN3	640..735	CDD:238020	24/94 (26%)
boi	NP_001096868.3	IG_like	42..131	CDD:214653	25/100 (25%)
		IG_like	154..234	CDD:214653	21/87 (24%)
		Ig	172..234	CDD:299845	16/62 (26%)
		IG_like	249..329	CDD:214653	24/86 (28%)
		Ig	257..329	CDD:299845	22/78 (28%)
		IG_like	339..418	CDD:214653	19/96 (20%)
		Ig	352..408	CDD:299845	17/73 (23%)
		FN3	470..592	CDD:238020	28/132 (21%)
		FN3	613..700	CDD:238020	25/100 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930