DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	944	Identity:	218/944 - (23%)
Similarity:	333/944 - (35%)	Gaps:	224/944 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QRKP--------VGKPLILTC--RPTVPEPSLVADLQWKDNRNNTILP--------KPNGRNQPP 88
            :|||        .|:..:|.|  .|....|.|.. ::|.  |...:||        .|  |..|.
  Rat    21 RRKPEVVSVVGRAGESAVLGCDLLPPAGRPPLHV-IEWL--RFGFLLPIFIQFGLYSP--RIDPD 80

  Fly    89 MYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPE-NQYPTLG 152
            ...........:|.|..|.||..|.|.|...:.:....|:.....::|.:|..:.|: .:.|.|.
  Rat    81 YVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQFQETPPLV 145

  Fly   153 ------QDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRA-- 209
                  :...:.|.....|.|.:.|...|..:.....:..|:...|.||.|:....|.|||:|
  Rat   146 LEVKELEAVTLRCVALGSPQPYVTWKFRGQDLGKGQGQVQVRNGTLWIRRVERGSAGDYTCQASS 210

  Fly   210 ---AVIETGELLERTIRVEVFIQPEIISLPTNLEAVE-GKPFAANCTARGKPVP-EISWIRDATQ 269
               :|..|.:||        .:.|.:|.:|.|...|. .:..:..|.|...|.. ..||.:|  :
  Rat   211 TEGSVTHTTQLL--------VLGPPVIVVPPNNNTVNASQDVSLACRAEAYPANLTYSWFQD--R 265

  Fly   270 LNVATADRFQVNPQ---TGLVTISSVSQDDYGTYTCLAKN------------------RAGVVDQ 313
            :||....|.|...:   .|.:.:.:...||.|.|||:..|                  :..|:..
  Rat   266 INVFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSNGFPHPPSASAYLTVLYPAQVTVMPP 330

  Fly   314 KTKLNVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILE 378
            :|.|.:.:|..|                  |...|..|.:.|..|....:..  |.|..|...|.
  Rat   331 ETPLPIGMRGVI------------------RCPVRANPPLLFVTWTKDGQAL--QLDKFPGWSLG 375

  Fly   379 PNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWE 443
            |.         |:|.|:.......|.|.|...|...        |...:|....:.:.||.|. :
  Rat   376 PE---------GSLVIALGNEDALGEYSCTPYNSLG--------TAGSSPVTRVLLKAPPAFI-D 422

  Fly   444 QRKAN----------LSCLAMGIPNATIEWHWNGRKIKD--LYDTNLKIVGTGPRSDLIVHPVTR 496
            |.|..          :.|.|.|.|...:.|...||.::.  ..|:|         :.||:.|:|:
  Rat   423 QPKEEYFQEVGRDLLIPCSARGDPPPIVSWAKVGRGLQGQAQVDSN---------NSLILRPLTK 478

  Fly   497 QYYSGYKCIATN--IHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGP--STELGLP-- 555
            :.:..::|.|.|  .|.|...::         :|....|..:|..::....:|.  |.|.|..
  Rat   479 EAHGRWECSARNAVAHVTISTNV---------YVLGTSPHVVTNVSVVPLPKGANVSWEPGFDGG 534

  Fly   556 -ILAYSVQYKE-ALNPDWSTAYNRSW-SPDSP-----YIVEGLRPQTEYSFRFAARNQVGLGNW- 611
             :..:||.|.. |..||.:   :..| |...|     .:|.||:..|:|.|...|:|::|.|.:
  Rat   535 YLQRFSVWYTPLAKRPDRA---HHDWVSLAVPMGATHLLVPGLQAYTQYQFSVLAQNKLGSGPFS 596

  Fly   612 --------GVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDR 668
                    |:....:.||....|.|.||..|    :....|.:|..  ..|.|..|....|.:|.
  Rat   597 EIVLSIPEGLPTTPAVPRLPPTEMPPPLSPP----RGLVAVRTPRG--VLLHWDPPELIPERLDG 655

  Fly   669 YQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMK 733
            |.::   |.:.|..|..|:......|:    ...:..|:.:..|...|.|......|.|::|...
  Rat   656 YILE---GRQGSQGWEILDQGVAGTEI----QLLVPGLIKDVLYEFRLVAFADSYVSDPSNIANI 713

  Fly   734 TTRGIDVIQVAER--QVFSSAAIVGIAIGGVLLL--LFVVDLLCCITVHMGVMATMCRKAKR--- 791
            :|.|::|.....:  .:.....:.|: :|||..|  ..:|.:|....::....|...||..|
  Rat   714 STSGLEVYPSRTQLPGLLPQPVLAGV-VGGVCFLGVAVLVSILAACLMNRRRAARRHRKRLRQDP 777

  Fly   792 ----SP-----------SEIDDEAKLGSLYGWRFPLPYCSGQLV-KEP--PPSPLPLPPPVKLGG 838
                ||           |:..|......|.|  .|:|.....|: .||  ||||.|..|   ||.
  Rat   778 PLIFSPRGRSGPHSAPGSDSPDSVTKFKLQG--SPVPSLRQSLLWGEPARPPSPHPDSP---LGR 837

  Fly   839 SPMSTPLDEKEPL-RTPTGSIKQNSTIEFDGRFV 871
            .|:  ||   ||: |.|            |||||
  Rat   838 GPL--PL---EPICRGP------------DGRFV 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	25/108 (23%)
		IG_like	144..226	CDD:214653	22/93 (24%)
		IGc2	152..209	CDD:197706	14/62 (23%)
		I-set	230..319	CDD:254352	26/111 (23%)
		IGc2	243..309	CDD:197706	18/88 (20%)
		IG_like	330..424	CDD:214653	17/93 (18%)
		IGc2	339..412	CDD:197706	16/72 (22%)
		Ig	447..518	CDD:143165	18/84 (21%)
		fn3	534..611	CDD:278470	24/88 (27%)
		FN3	640..735	CDD:238020	20/94 (21%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	21/86 (24%)
		Ig strand A	136..139	CDD:409353	1/2 (50%)
		IG_like	143..223	CDD:214653	20/87 (23%)
		Ig strand A'	145..148	CDD:409353	0/2 (0%)
		Ig strand B	154..161	CDD:409353	1/6 (17%)
		Ig strand C	167..172	CDD:409353	1/4 (25%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	1/3 (33%)
		Ig strand F	202..210	CDD:409353	5/7 (71%)
		Ig strand G	213..223	CDD:409353	4/17 (24%)
		Ig_3	226..305	CDD:404760	22/80 (28%)
		putative Ig strand A	226..230	CDD:409353	1/3 (33%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	1/9 (11%)
		putative Ig strand C'	267..270	CDD:409353	2/2 (100%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	1/5 (20%)
		putative Ig strand F	297..305	CDD:409353	4/7 (57%)
		putative Ig strand G	310..319	CDD:409353	0/8 (0%)
		Ig	322..407	CDD:416386	23/121 (19%)
		Ig strand A'	324..328	CDD:409353	0/3 (0%)
		Ig strand B	333..347	CDD:409353	4/31 (13%)
		Ig strand C	353..359	CDD:409353	2/5 (40%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	0/2 (0%)
		Ig strand E	378..382	CDD:409353	2/3 (67%)
		Ig strand F	391..399	CDD:409353	3/7 (43%)
		Ig	418..503	CDD:416386	22/103 (21%)
		Ig strand A	418..421	CDD:409353	1/2 (50%)
		Ig strand A'	427..430	CDD:409353	0/2 (0%)
		Ig strand B	436..443	CDD:409353	1/6 (17%)
		Ig strand C	449..454	CDD:409353	1/4 (25%)
		Ig strand C'	457..459	CDD:409353	1/1 (100%)
		Ig strand D	462..466	CDD:409353	0/3 (0%)
		Ig strand E	469..473	CDD:409353	1/3 (33%)
		Ig strand F	482..490	CDD:409353	2/7 (29%)
		Ig strand G	493..503	CDD:409353	2/18 (11%)
		FN3	508..599	CDD:238020	25/93 (27%)
		FN3	625..715	CDD:238020	21/102 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807		8/40 (20%)
		PHA03247	<777..1062	CDD:223021	31/100 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846		15/34 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900