DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fas2 and Ncam2

DIOPT Version :10

Sequence 1:NP_001284854.1 Gene:Fas2 / 31364 FlyBaseID:FBgn0000635 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_981954.2 Gene:Ncam2 / 288280 RGDID:1303131 Length:837 Species:Rattus norvegicus


Alignment Length:901 Identity:243/901 - (26%)
Similarity:381/901 - (42%) Gaps:101/901 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTI 77
            ::|||....|..|..:...:|::..........||:....|| ..:.||.   .:.|.:.:...|
  Rat     1 MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTC-TAIGEPE---SIDWYNPQGEKI 61

  Fly    78 LPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTN 142
            :     ..|..|..:  .|....|.|.:.::|..|.|.|.|:.|..:..|..|.::.|..:|:..
  Rat    62 I-----STQRVMLQK--EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFRE 119

  Fly   143 APENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDK--YVVQTNGLLIRNVQESDEGIY 205
            ....|....|:|..|:|.|.:.|.|.:.||.:.:.:.|..|.  .|:..|.|.|.|:.:||||||
  Rat   120 VLSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQILNINKSDEGIY 184

  Fly   206 TCRAAVIETGELLERTIRVEVFIQPEIISLPT---NLEAVEGKPFAANCTARGKPVPEISWIRDA 267
            .|...|...||:..|.|.|.|.:.|.|: :|.   |..|..|:.....|.|.|.|.|.|||.|:.
  Rat   185 RCEGRVEARGEIDFRDIIVIVNVPPAIV-MPQKSFNATAERGEEMTLTCKASGSPDPAISWFRNG 248

  Fly   268 TQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVT 332
            ..  :...:::.:......:|:.::...|.|:|.|.|.|:||...::..|.|.|:|.|.:|.|.|
  Rat   249 KL--IEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNET 311

  Fly   333 GARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGE-STGTLRISN 396
            .:....:.:.|.|:|.|.|.||::|......::.|.:..|.||       |.:|: ...:|.|.:
  Rat   312 TSENGHVTLICEAEGEPVPEITWKRAIDGVTFSEGDKSPDGRI-------EVKGQHGRSSLHIRD 369

  Fly   397 AERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATI 461
            .:.||.|.|.|.|.::.....::.|:.:|:||.|...:.:  .:|||....|:||.....|.|:|
  Rat   370 VKLSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTM--YYSWEGNPINISCDVKANPPASI 432

  Fly   462 EWHWNGRKI----KDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEA 522
              ||...|:    |:  .|:||....|.:..|.:.|.:...:..|.|.|||..||...:..|:.|
  Rat   433 --HWRREKLVLPAKN--TTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELA 493

  Fly   523 RVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIV 587
            .||......|..:|:.||.......|.:..|:||..|.|..||..:..|...  ||....:..::
  Rat   494 DVPSSPRGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVTSETWKIV--RSHGVQTTVVL 556

  Fly   588 EGLRPQTEYSFRFAARNQVGLGNWG-VNQQQSTPRRSAPEEPKP--LHNPVQHDKEEPVVVSPYS 649
            ..|.|.|.|..|.||.|..|.|::. :...|:.|.|    ||.|  :|......|...:.::...
  Rat   557 SSLEPNTTYEVRVAAVNGKGQGDYSKIEIFQTLPVR----EPSPPSIHGQPSSGKSFKISITKQD 617

  Fly   650 DHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRI 714
                       |.|.||..|.:||....| ...|.|.:...|...::      :..|.....|.:
  Rat   618 -----------DGGAPILEYIVKYRSKDK-EDQWLEKKVQGNKDHII------LEHLQWTMGYEV 664

  Fly   715 ELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHM 779
            ::.|.|.:|||.|...........::|:..........||:|:.:..:||:|.|.|:.|......
  Rat   665 QITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAIIGLGVAALLLILVVTDVSCFFIRQC 729

  Fly   780 GVMATMCRK--AKRSPS-----EIDDEAKLGSLY-GWRFPL-----------PYCSGQLVKEPPP 825
            |::..:.|:  .|:|.|     |: :|.|...|. |.:.|:           .:..|..|.||..
  Rat   730 GLLMCITRRMCGKKSGSSGKSKEL-EEGKAAYLKDGSKEPIVEMRTEDERITNHEDGSPVNEPNE 793

  Fly   826 SPLPLPPPVKLGGSPMSTPLDE---KEPLRTPTGSIKQNSTIEFDGRFVHSRSGEI 878
            : .||..|.||       ||.|   ||.|...|..||.::.|      :.|:..:|
  Rat   794 T-TPLTEPEKL-------PLKEENGKEVLNAETIEIKVSNDI------IQSKEDDI 835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fas2NP_001284854.1 Ig 33..121 CDD:472250 19/87 (22%)
Ig strand B 50..54 CDD:409353 0/3 (0%)
Ig strand C 66..70 CDD:409353 0/3 (0%)
Ig strand E 99..103 CDD:409353 1/3 (33%)
Ig strand F 113..118 CDD:409353 2/4 (50%)
Ig 139..209 CDD:472250 25/71 (35%)
Ig strand B 156..159 CDD:409353 1/2 (50%)
Ig strand C 168..172 CDD:409353 0/3 (0%)
Ig strand E 190..194 CDD:409353 2/3 (67%)
Ig strand F 204..209 CDD:409353 3/4 (75%)
IgI_4_MYLK-like 229..319 CDD:409568 25/92 (27%)
Ig strand A 229..232 CDD:409568 1/2 (50%)
Ig strand A' 238..241 CDD:409568 1/2 (50%)
Ig strand B 246..254 CDD:409568 1/7 (14%)
Ig strand C 260..264 CDD:409568 2/3 (67%)
Ig strand C' 267..270 CDD:409568 0/2 (0%)
Ig strand D 277..281 CDD:409568 0/3 (0%)
Ig strand E 285..290 CDD:409568 1/4 (25%)
Ig strand F 298..306 CDD:409568 4/7 (57%)
Ig strand G 309..319 CDD:409568 2/9 (22%)
IG_like 330..424 CDD:214653 25/94 (27%)
Ig strand B 339..343 CDD:409353 0/3 (0%)
Ig strand C 352..356 CDD:409353 2/3 (67%)
Ig strand E 388..394 CDD:409353 1/5 (20%)
Ig strand F 404..409 CDD:409353 2/4 (50%)
Ig 447..515 CDD:409353 23/71 (32%)
Ig strand B 447..451 CDD:409353 1/3 (33%)
Ig strand C 460..464 CDD:409353 1/3 (33%)
Ig strand E 487..491 CDD:409353 1/3 (33%)
Ig strand F 501..506 CDD:409353 2/4 (50%)
FN3 525..619 CDD:238020 27/94 (29%)
FN3 640..735 CDD:238020 19/94 (20%)
Ncam2NP_981954.2 IgI_1_NCAM-2 21..113 CDD:409452 22/102 (22%)
Ig strand A 21..26 CDD:409452 1/4 (25%)
Ig strand A' 29..33 CDD:409452 0/3 (0%)
Ig strand B 35..45 CDD:409452 3/10 (30%)
Ig strand C 49..55 CDD:409452 1/8 (13%)
Ig strand C' 58..60 CDD:409452 0/1 (0%)
Ig strand D 66..72 CDD:409452 1/7 (14%)
Ig strand E 74..82 CDD:409452 2/7 (29%)
Ig strand F 89..96 CDD:409452 3/6 (50%)
Ig strand G 101..112 CDD:409452 2/10 (20%)
Ig 117..193 CDD:472250 25/75 (33%)
Ig strand B 132..136 CDD:409353 1/3 (33%)
Ig strand C 145..152 CDD:409353 2/6 (33%)
Ig strand E 169..173 CDD:409353 2/3 (67%)
Ig strand F 183..187 CDD:409353 2/3 (67%)
Ig strand G 191..194 CDD:409353 0/2 (0%)
IgI_1_MuSK 209..298 CDD:409562 25/91 (27%)
Ig strand A 209..212 CDD:409562 1/2 (50%)
Ig strand A' 217..222 CDD:409562 1/4 (25%)
Ig strand B 228..235 CDD:409562 1/6 (17%)
Ig strand C 241..246 CDD:409562 3/4 (75%)
Ig strand C' 248..250 CDD:409562 0/1 (0%)
Ig strand D 257..260 CDD:409562 0/2 (0%)
Ig strand E 264..270 CDD:409562 1/5 (20%)
Ig strand F 277..284 CDD:409562 3/6 (50%)
Ig strand G 290..298 CDD:409562 1/7 (14%)
Ig 300..397 CDD:472250 29/103 (28%)
Ig strand B 318..322 CDD:409353 0/3 (0%)
Ig strand C 331..335 CDD:409353 2/3 (67%)
Ig strand E 363..367 CDD:409353 1/3 (33%)
Ig strand F 377..382 CDD:409353 2/4 (50%)
Ig strand G 390..393 CDD:409353 0/2 (0%)
Ig_3 401..479 CDD:464046 24/83 (29%)
FN3 496..588 CDD:238020 26/93 (28%)
fn3 594..678 CDD:394996 22/101 (22%)

Return to query results.
Submit another query.