DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	243/901 - (26%)
Similarity:	381/901 - (42%)	Gaps:	101/901 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTI 77
            ::|||....|..|..:...:|::..........||:....|| ..:.||.   .:.|.:.:...|
  Rat     1 MSLLLSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTC-TAIGEPE---SIDWYNPQGEKI 61

  Fly    78 LPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTN 142
            :     ..|..|..:  .|....|.|.:.::|..|.|.|.|:.|..:..|..|.::.|..:|:..
  Rat    62 I-----STQRVMLQK--EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFRE 119

  Fly   143 APENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDK--YVVQTNGLLIRNVQESDEGIY 205
            ....|....|:|..|:|.|.:.|.|.:.||.:.:.:.|..|.  .|:..|.|.|.|:.:||||||
  Rat   120 VLSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQILNINKSDEGIY 184

  Fly   206 TCRAAVIETGELLERTIRVEVFIQPEIISLPT---NLEAVEGKPFAANCTARGKPVPEISWIRDA 267
            .|...|...||:..|.|.|.|.:.|.|: :|.   |..|..|:.....|.|.|.|.|.|||.|:.
  Rat   185 RCEGRVEARGEIDFRDIIVIVNVPPAIV-MPQKSFNATAERGEEMTLTCKASGSPDPAISWFRNG 248

  Fly   268 TQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVT 332
            ..  :...:::.:......:|:.::...|.|:|.|.|.|:||...::..|.|.|:|.|.:|.|.|
  Rat   249 KL--IEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNET 311

  Fly   333 GARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGE-STGTLRISN 396
            .:....:.:.|.|:|.|.|.||::|......::.|.:..|.||       |.:|: ...:|.|.:
  Rat   312 TSENGHVTLICEAEGEPVPEITWKRAIDGVTFSEGDKSPDGRI-------EVKGQHGRSSLHIRD 369

  Fly   397 AERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATI 461
            .:.||.|.|.|.|.::.....::.|:.:|:||.|...:.:  .:|||....|:||.....|.|:|
  Rat   370 VKLSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTM--YYSWEGNPINISCDVKANPPASI 432

  Fly   462 EWHWNGRKI----KDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEA 522
              ||...|:    |:  .|:||....|.:..|.:.|.:...:..|.|.|||..||...:..|:.|
  Rat   433 --HWRREKLVLPAKN--TTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELA 493

  Fly   523 RVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIV 587
            .||......|..:|:.||.......|.:..|:||..|.|..||..:..|...  ||....:..::
  Rat   494 DVPSSPRGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVTSETWKIV--RSHGVQTTVVL 556

  Fly   588 EGLRPQTEYSFRFAARNQVGLGNWG-VNQQQSTPRRSAPEEPKP--LHNPVQHDKEEPVVVSPYS 649
            ..|.|.|.|..|.||.|..|.|::. :...|:.|.|    ||.|  :|......|...:.::...
  Rat   557 SSLEPNTTYEVRVAAVNGKGQGDYSKIEIFQTLPVR----EPSPPSIHGQPSSGKSFKISITKQD 617

  Fly   650 DHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRI 714
                       |.|.||..|.:||....| ...|.|.:...|...::      :..|.....|.:
  Rat   618 -----------DGGAPILEYIVKYRSKDK-EDQWLEKKVQGNKDHII------LEHLQWTMGYEV 664

  Fly   715 ELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHM 779
            ::.|.|.:|||.|...........::|:..........||:|:.:..:||:|.|.|:.|......
  Rat   665 QITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAIIGLGVAALLLILVVTDVSCFFIRQC 729

  Fly   780 GVMATMCRK--AKRSPS-----EIDDEAKLGSLY-GWRFPL-----------PYCSGQLVKEPPP 825
            |::..:.|:  .|:|.|     |: :|.|...|. |.:.|:           .:..|..|.||..
  Rat   730 GLLMCITRRMCGKKSGSSGKSKEL-EEGKAAYLKDGSKEPIVEMRTEDERITNHEDGSPVNEPNE 793

  Fly   826 SPLPLPPPVKLGGSPMSTPLDE---KEPLRTPTGSIKQNSTIEFDGRFVHSRSGEI 878
            : .||..|.||       ||.|   ||.|...|..||.::.|      :.|:..:|
  Rat   794 T-TPLTEPEKL-------PLKEENGKEVLNAETIEIKVSNDI------IQSKEDDI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/93 (23%)
		IG_like	144..226	CDD:214653	30/83 (36%)
		IGc2	152..209	CDD:197706	23/58 (40%)
		I-set	230..319	CDD:254352	25/91 (27%)
		IGc2	243..309	CDD:197706	17/65 (26%)
		IG_like	330..424	CDD:214653	25/94 (27%)
		IGc2	339..412	CDD:197706	22/73 (30%)
		Ig	447..518	CDD:143165	23/74 (31%)
		fn3	534..611	CDD:278470	24/76 (32%)
		FN3	640..735	CDD:238020	19/94 (20%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452	22/102 (22%)
		Ig strand B	38..42	CDD:409452	0/3 (0%)
		Ig strand C	50..54	CDD:409452	0/3 (0%)
		Ig strand E	76..80	CDD:409452	1/3 (33%)
		Ig strand F	90..95	CDD:409452	2/4 (50%)
		Ig strand G	104..107	CDD:409452	1/2 (50%)
		IGc2	128..189	CDD:197706	23/60 (38%)
		Ig strand B	130..139	CDD:409353	3/8 (38%)
		Ig strand C	145..153	CDD:409353	2/7 (29%)
		Ig strand C'	156..159	CDD:409353	1/2 (50%)
		Ig strand D	162..167	CDD:409353	1/4 (25%)
		Ig strand E	168..175	CDD:409353	3/6 (50%)
		IgI_1_MuSK	209..298	CDD:409562	25/91 (27%)
		Ig strand B	228..232	CDD:409562	0/3 (0%)
		Ig strand C	241..245	CDD:409562	2/3 (67%)
		Ig strand E	264..268	CDD:409562	0/3 (0%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	29/103 (28%)
		Ig strand A	300..305	CDD:409353	2/4 (50%)
		Ig strand A'	309..313	CDD:409353	2/3 (67%)
		Ig strand B	317..325	CDD:409353	1/7 (14%)
		Ig strand C	331..337	CDD:409353	2/5 (40%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	3/12 (25%)
		Ig strand E	362..368	CDD:409353	1/5 (20%)
		Ig strand F	376..384	CDD:409353	4/7 (57%)
		Ig strand G	387..397	CDD:409353	1/9 (11%)
		Ig_3	401..479	CDD:404760	24/83 (29%)
		Ig strand B	418..422	CDD:409353	1/3 (33%)
		Ig strand C	431..435	CDD:409353	2/5 (40%)
		Ig strand E	458..462	CDD:409353	1/3 (33%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	26/93 (28%)
		fn3	594..678	CDD:394996	22/101 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3018
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm45717
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.740