DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fas2 and LRIT1

DIOPT Version :9

Sequence 1:NP_001284854.1 Gene:Fas2 / 31364 FlyBaseID:FBgn0000635 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_056428.1 Gene:LRIT1 / 26103 HGNCID:23404 Length:623 Species:Homo sapiens


Alignment Length:319 Identity:72/319 - (22%)
Similarity:111/319 - (34%) Gaps:74/319 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 PEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIR-DATQLNVATADRFQVNPQTG--LVTISS 291
            ||:.....::.::.|......|.|.|.|.||:||.| :...|| .|..:...:..|.  |:.:.:
Human   254 PELHPGVASIRSLLGGTALLRCGATGVPGPEMSWRRANGRPLN-GTVHQEVSSDGTSWTLLGLPA 317

  Fly   292 VSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYE-------LYNVTGARTKEIAITCRAKGR- 348
            ||..|.|.|.|.|||..|..:....|.|...|...|       |:..||...:..|...:...| 
Human   318 VSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVARH 382

  Fly   349 ----PAPAITFRRWG-----TQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGL 404
                |.||:.  ..|     |:||.|               .:..:.::.|.|....|..|:..:
Human   383 VPQIPKPAVL--ATGPSVPSTKEELT---------------LEHFQMDALGELSDGRAGPSEARM 430

  Fly   405 YQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRK 469
            .:                :|:...|..|...|    .|:..:|. :..|..:..|....|...|.
Human   431 VR----------------SVKVVGDTYHSVSL----VWKAPQAK-NTTAFSVLYAVFGQHSMRRV 474

  Fly   470 IKDLYDTNLKIVGTGPRSDLI-------VHPVTRQYYSGYKCI--ATNIHGTAEHDMQL 519
            |.....|.:.|.|..|::..:       :.|...|      |:  :||....||:..||
Human   475 IVQPGKTRVTITGLLPKTKYVACVCVQGLVPRKEQ------CVIFSTNEVVDAENTQQL 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fas2NP_001284854.1 IG_like 39..133 CDD:214653
IG_like 144..226 CDD:214653
IGc2 152..209 CDD:197706
I-set 230..319 CDD:254352 28/91 (31%)
IGc2 243..309 CDD:197706 24/68 (35%)
IG_like 330..424 CDD:214653 16/103 (16%)
IGc2 339..412 CDD:197706 14/82 (17%)
Ig 447..518 CDD:143165 17/79 (22%)
fn3 534..611 CDD:278470
FN3 640..735 CDD:238020
LRIT1NP_056428.1 LRR 1 60..81
leucine-rich repeat 61..84 CDD:275378
LRR_8 63..143 CDD:290566
LRR 2 84..105
leucine-rich repeat 85..132 CDD:275378
LRR 3 108..129
LRR_8 131..202 CDD:290566
LRR_4 131..171 CDD:289563
LRR 4 132..153
leucine-rich repeat 133..156 CDD:275378
LRR 5 156..177
leucine-rich repeat 157..180 CDD:275378
leucine-rich repeat 181..205 CDD:275378
TPKR_C2 201..>240 CDD:301599
Ig 267..345 CDD:299845 26/78 (33%)
IG_like 267..345 CDD:214653 26/78 (33%)
FN3 431..498 CDD:214495 15/87 (17%)
LRR 6. /evidence=ECO:0000305 571..594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.