DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and NEGR1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	291	Identity:	83/291 - (28%)
Similarity:	123/291 - (42%)	Gaps:	40/291 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 VAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQTN---------- 190
            |...|. |.:|.....|...|:.|.:: |......||.....|....||:.|...
Human    38 VDFPWA-AVDNMMVRKGDTAVLRCYLE-DGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRD 100

  Fly   191 -GLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQ--PEIISLPTNLEAVEGKPFAANCT 252
             .|.|:||..:|:|.|||......|    .||::|.:.:|  |:|..:..::...||......|.
Human   101 YSLQIQNVDVTDDGPYTCSVQTQHT----PRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCL 161

  Fly   253 ARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVD-QKTK 316
            |.|||.|.|||...:     .:|..|: |.|  .:.|..:::|..|.|.|.|:|.....| :|.|
Human   162 ATGKPEPSISWRHIS-----PSAKPFE-NGQ--YLDIYGITRDQAGEYECSAENDVSFPDVRKVK 218

  Fly   317 LNVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNF 381
            :.|...|.|.|:.:.|....:...|.|...|.|.||  |..:..:::..||||.    ||:: ||
Human   219 VVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPA--FEWYKGEKKLFNGQQG----IIIQ-NF 276

  Fly   382 DEERGESTGTLRISNAERSDDGLYQCIARNK 412
                 .:...|.::|..:...|.|.|:|.||
Human   277 -----STRSILTVTNVTQEHFGNYTCVAANK 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	24/92 (26%)
		IGc2	152..209	CDD:197706	19/67 (28%)
		I-set	230..319	CDD:254352	27/89 (30%)
		IGc2	243..309	CDD:197706	22/65 (34%)
		IG_like	330..424	CDD:214653	24/83 (29%)
		IGc2	339..412	CDD:197706	21/72 (29%)
		Ig	447..518	CDD:143165
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
NEGR1	NP_776169.2	IG	47..135	CDD:214652	24/92 (26%)
		IGc2	152..210	CDD:197706	22/65 (34%)
		Ig_3	225..301	CDD:372822	25/87 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900