DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fas2 and Il1rap

DIOPT Version :9

Sequence 1:NP_001284854.1 Gene:Fas2 / 31364 FlyBaseID:FBgn0000635 Length:885 Species:Drosophila melanogaster
Sequence 2:XP_038943965.1 Gene:Il1rap / 25466 RGDID:2893 Length:697 Species:Rattus norvegicus


Alignment Length:625 Identity:122/625 - (19%)
Similarity:200/625 - (32%) Gaps:231/625 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 YCTASYANTEILEKGVTI---------KTYVA-----ITWTNAPENQYPTLGQDYVVMCEVKADP 165
            ||:......|:::|....         :.|:.     ||..|. :..:|:         .||   
  Rat   133 YCSKVAFPLEVV
QKDSCFNSPMRLPVHRLYIEQGIHNITCPNV-DGYFPS---------SVK--- 184

  Fly   166 NPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQ-----ESDEGIYTCRAAVIETGEL--LERTIR 223
             |::.|.:....|...::   ||..|:   |:.     .|:.|.|||....:|.|.|  |.||:.
  Rat   185 -PSVTWYKGCTEIVNFHN---VQPKGM---NLSFFIPLVSNNGNYTCVVTYLENGRLFHLTRTMT 242

  Fly   224 VEVF------IQPEIISLPTNLEAVEGKPFAANCTARGKP--VP-------------EISWIRDA 267
            |:|.      :.|.|.| |.:....|.:|        |:.  :|             ||.|..|.
  Rat   243 VKVVG
SPKDAVPPHIYS-PNDRVVYEKEP--------GEELVIPCKVYFSFIMDSHNEIWWTIDG 298

  Fly   268 TQLNVATADRFQVN-----------PQTGLVTISSVSQDDY-GTYTCLAKNRAGVVDQKTKLNVL 320
            .:.:....| ..:|           .:|.:::|..|:.:|. ..|.|.|:|..|..:|..|:...
  Rat   299 KKPDDVPVD-ITINESVSYSSTEDETRTQILSIKKVTPEDLKRNYVCHARNAEGEAEQAAKVKQK 362

  Fly   321 VRPQIY--ELYNVTGART--------------KEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQ 369
            |.|..|  ||....||..              .|:.:..||           .:||.|...:| :
  Rat   363 VIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRA-----------HFGTDETILDG-K 415

  Fly   370 DDDPRIILEPNFDEE-------RG--ESTGTLRISNAERSD-------DGLYQCIARNKG----- 413
            :.|..:....|.:||       ||  |:....::...:|..       :.::..|.|::.     
  Rat   416 EYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVL 480

  Fly   414 ---------------------ADAYKTGHITVEFA------PDFSHMKELPPVFSWEQRKANLS- 450
                                 .::..|..|.||:.      |....:||.....||:..|:..| 
  Rat   481 SPDYVTEKSISMLEFKLGVMCQNSIATKLIVVEYRPLEQPHPGIMQLKESVSFVSWKGEKSKHSG 545

  Fly   451 -------CLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATN 508
                   .||:.:.:.:....||              .....:||:.:..|.|:           
  Rat   546 SKFWKALRLALPLRSLSASSGWN--------------ESCSSQSDISLDHVQRR----------- 585

  Fly   509 IHGTAEHDMQLKE-------------ARVPDFVSE--AKPSQLTATTMTFDIRGPSTELGLPILA 558
                    .:|||             |..|..:|:  .|||......:|: ..|.|.      |.
  Rat   586 --------SRLKEPPELQSSERVSGAAPAPGTISKHRGKPSAACRCCVTY-CEGESH------LR 635

  Fly   559 YSVQYKEALNPDWSTAYNRSWSPD-----SPYIVEGLRPQ 593
            ...:.:...:|.|.|   ....||     |.:|..|.||:
  Rat   636 SKSRAEMHTHPQWET---HLCKPDLQESESQWIQNGTRPE 672

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fas2NP_001284854.1 IG_like 39..133 CDD:214653 4/26 (15%)
IG_like 144..226 CDD:214653 22/88 (25%)
IGc2 152..209 CDD:197706 14/61 (23%)
I-set 230..319 CDD:254352 25/115 (22%)
IGc2 243..309 CDD:197706 18/92 (20%)
IG_like 330..424 CDD:214653 21/149 (14%)
IGc2 339..412 CDD:197706 16/88 (18%)
Ig 447..518 CDD:143165 9/78 (12%)
fn3 534..611 CDD:278470 15/65 (23%)
FN3 640..735 CDD:238020
Il1rapXP_038943965.1 Ig1_IL1R_like 37..144 CDD:409584 3/10 (30%)
Ig strand B 55..59 CDD:409584
Ig strand C 79..83 CDD:409584
Ig strand E 109..113 CDD:409584
Ig strand F 123..128 CDD:409584
Ig strand G 136..139 CDD:409584 0/2 (0%)
Ig 155..247 CDD:416386 27/111 (24%)
Ig strand A 157..162 CDD:409353 0/4 (0%)
Ig strand A 157..162 CDD:409353 0/4 (0%)
Ig strand B 168..172 CDD:409353 1/3 (33%)
Ig strand B 168..172 CDD:409353 1/3 (33%)
Ig strand C 186..191 CDD:409353 1/4 (25%)
Ig strand C 186..191 CDD:409353 1/4 (25%)
Ig strand C' 194..196 CDD:409353 0/1 (0%)
Ig strand C' 194..196 CDD:409353 0/1 (0%)
Ig strand D 201..205 CDD:409353 2/6 (33%)
Ig strand D 201..205 CDD:409353 2/6 (33%)
Ig strand E 207..212 CDD:409353 1/7 (14%)
Ig strand E 207..212 CDD:409353 1/7 (14%)
Ig strand F 221..230 CDD:409353 3/8 (38%)
Ig strand F 221..230 CDD:409353 3/8 (38%)
Ig strand G 233..246 CDD:409353 5/12 (42%)
Ig strand G 233..246 CDD:409353 5/12 (42%)
Ig3_IL1RAP 255..361 CDD:409525 25/115 (22%)
Ig strand B 274..278 CDD:409525 0/3 (0%)
Ig strand C 291..295 CDD:409525 2/3 (67%)
Ig strand E 326..330 CDD:409525 0/3 (0%)
Ig strand F 341..346 CDD:409525 2/4 (50%)
Ig strand G 353..356 CDD:409525 0/2 (0%)
TIR 416..559 CDD:214587 23/142 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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