DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	872	Identity:	201/872 - (23%)
Similarity:	309/872 - (35%)	Gaps:	224/872 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 PKP------NGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTY-- 135
            |:|      :||..||.....:..|:..:::::::.: .|:||..|      :.:|....||.
Mouse   145 PRPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPD-AGRYYVQA------VNDKNGDNKTSQP 202

  Fly   136 --------------VAITWTNAPENQYPTLGQDYVVMCEVKADPNPTID----WLRNGDPIRTTN 182
                          :|.|....|:|.....|...|.| |..|:..|.|.    |.::|.|:.:..
Mouse   203 ITLAVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTM-ECVANARPLIKLHIVWKKDGAPLSSGI 266

  Fly   183 DKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGEL-LERTIRVEVFIQPEIISLP-----TNLEA 241
            ..|   ...|.|.|...||.|.|.|.|.:..:... :.|...:.|...|:.:..|     ..:|.
Mouse   267 SDY---NRRLTIANPTVSDAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEK 328

  Fly   242 VEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKN 306
            |...|    |.|:|.|.|.|:|.:||..:.|....||:.....|| .||.:..||.|...|.|.|
Mouse   329 VVDIP----CRAKGVPPPSITWYKDAALVEVGKLTRFKQRSDGGL-QISGLLPDDTGMLQCFAHN 388

  Fly   307 RAGVVDQKTKLNVL-VRPQIYE-LYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQ 369
            .||.....|.|.|. :.|.|.. ..:.|......:.:.|...|.|.||||   |...|.......
Mouse   389 AAGEAQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT---WQKGERILASGS 450

  Fly   370 DDDPRI-ILEPNFDEERGESTGTLRISNAERSDDGLYQCIARN-KGADAYKTGHITVEFAPD--- 429
            ...||. :||          :|:|.||....||.|.|.|:|.| :|.|         |.:.|
Mouse   451 VQLPRFTLLE----------SGSLLISPTHISDAGTYTCLATNSRGVD---------EASADLVV 496

  Fly   430 FSHMKELPPVFSWEQRKANLSCLAMGI---PNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDL-- 489
            ::..:...|.......|...:.:..|:   |..|:.:.|.       .|.....|.|.||..|
Mouse   497 WARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTVRYVWE-------KDGATLAVETNPRIRLDR 554

  Fly   490 --IVHPVTRQYYSG----YKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIR-- 546
              .:|  ..|.:||    |.|...:..|....:..|:..::|.     .|....||..|.:.|
Mouse   555 NGSLH--ISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPH-----APEHPVATLSTVERRAI 612

  Fly   547 ---------GPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYI-VEGLRPQTEYSFRFA 601
                     |.|     |::.|.::..|. |..| |....|..|::..: |:||.|...|.||..
Mouse   613 NLTWAKPFDGNS-----PLMRYVLEMSEN-NAPW-TILLASVDPEATSVMVKGLVPARSYQFRLC 670

  Fly   602 ARNQVGLGNWGVNQQQSTPRRSAPEEP--KPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGE 664
            |.|.||.|.:    .:.|.|.|.||||  .|..|.:...:....::        ::|..|.::.:
Mouse   671 AVNDVGKGQF----SKDTERVSLPEEPPTAPPQNVIASGRTNQSIM--------IQWQPPPESHQ 723

  Fly   665 P--IDRYQIKYC-PGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIG--- 723
            .  :..|.|:|| .|:.:...:..:.::       :..:..:..|:..|.|.||:.|:|:.|
Mouse   724 NGILKGYIIRYCLAGLPVGYQFKNITDA-------DVNNLLLEDLIIWTNYEIEVAAYNSAGLGV 781

  Fly   724 YSS--------------PASIIMKTT-----------------RGI---------------DVIQ 742
            |||              |.::..:.|                 .||               :|..
Mouse   782 YSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPAQEEEVTM 846

  Fly   743 VAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHMG-------------------------VM 782
            |..|..|..:..||...|......:...:||..|...|                         ::
Mouse   847 VTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDVPGPVGHLSFNDIL 911

  Fly   783 ATMCRKAKRSPSEIDDEAKLGSLYGWR 809
            .|..:.:.:.|.|     |.|.|.|:|
Mouse   912 DTSLKVSWQEPGE-----KNGILTGYR 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	12/59 (20%)
		IG_like	144..226	CDD:214653	23/86 (27%)
		IGc2	152..209	CDD:197706	19/60 (32%)
		I-set	230..319	CDD:254352	31/93 (33%)
		IGc2	243..309	CDD:197706	23/65 (35%)
		IG_like	330..424	CDD:214653	27/95 (28%)
		IGc2	339..412	CDD:197706	24/74 (32%)
		Ig	447..518	CDD:143165	17/81 (21%)
		fn3	534..611	CDD:278470	26/88 (30%)
		FN3	640..735	CDD:238020	19/114 (17%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653
		IGc2	44..102	CDD:197706
		IG_like	124..207	CDD:214653	14/68 (21%)
		Ig	136..192	CDD:299845	11/53 (21%)
		IG_like	226..308	CDD:214653	22/85 (26%)
		IGc2	237..290	CDD:197706	18/56 (32%)
		I-set	312..401	CDD:254352	31/93 (33%)
		Ig	330..398	CDD:143165	25/72 (35%)
		I-set	406..496	CDD:254352	31/111 (28%)
		Ig	420..496	CDD:299845	28/97 (29%)
		Ig	506..590	CDD:299845	19/92 (21%)
		IG_like	506..590	CDD:214653	19/92 (21%)
		FN3	594..685	CDD:238020	28/106 (26%)
		FN3	697..790	CDD:238020	20/107 (19%)
		FN3	798..894	CDD:238020	15/95 (16%)
		FN3	899..987	CDD:238020	8/40 (20%)
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900