DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and Ptprq

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	951	Identity:	203/951 - (21%)
Similarity:	343/951 - (36%)	Gaps:	277/951 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ETLPGESLALMITSLSV-----------EMGGK---YYCTASYANTEILEKGVTIKTYVAITWTN 142
            |:.||:.:.|.:.:|:.           :..||   :..:..:|.:.|:.|.|:||....:: ..
Mouse   153 ESAPGKVVNLTVEALNYSAVNLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIKVEDLLS-GK 216

  Fly   143 APENQYPTLGQDYVVMCEVKAD--------PNPTIDWLRNGDPIRTTNDKYVVQTN--------- 190
            .||             |...:|        |:||:.  |...|:|||:....:..|
Mouse   217 LPE-------------CNENSDSFLWSTTSPSPTLS--RATPPLRTTHLSNTLARNKISSVWKEP 266

  Fly   191 -GLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANC--- 251
             ..::.:::.....::...|...|.|           :|...|:..|.::.  ||.|  .||
Mouse   267 ISFVVTHLRPYTTYLFEVSAVTTEAG-----------YIDSTIVRTPESVP--EGPP--QNCITG 316

  Fly   252 TARGKPVPEISWIRDATQLNVATAD---RFQVNPQTGLVTISSVSQ-----------DDYGTYTC 302
            ...||.. .|||...|    :.|..   |.::...||.:..:|...           ..|..|..
Mouse   317 NVTGKAF-SISWDPPA----IVTGKFSYRVELYGPTGRILDNSTKDLRFVFTHLTPFTMYDVYVA 376

  Fly   303 LAKNRAGVVDQKTKLNVLVRPQ----IYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGT--- 360
             |:..|| |..|:.|:|...|.    :::| .:......||.::.|...:|...|:..|...
Mouse   377 -AETSAG-VGPKSNLSVFTPPDVPGAVFDL-QIVEVEATEIRVSWRKPRQPNGIISQYRVKVSVL 438

  Fly   361 -------------QEEYTNGQQDDDPRIILEP--NFDEERGESTGTLR-----ISNAE------- 398
                         |:||.|.....:...:::|  .|.|..||.:..|.     |.|:.
Mouse   439 ESGVILENTLLTGQDEYINNPMTPEIMNLVDPMIGFYEGSGEMSSDLHSLASFIYNSHPHDFPAR 503

  Fly   399 -RSDDGLYQCI--ARNKGADAYKTGHIT------VEFAPD------FSHMKELPP----VFSWEQ 444
             |.:|.....:  .||:........|::      |.|...      |:.|.|.||    |.:.||
Mouse   504 TRVEDQRSPVVVATRNQYMTDIAAEHLSYVIRRLVPFTEHTISVSAFTVMGEGPPTVLTVRTREQ 568

  Fly   445 RKANLSCL-AMGIPNATIEWHW------NGRKIK--DLY----DTNLKIVGTGPRSDLIVHPVTR 496
            ..:::..: ...|.:::|..:|      || ||.  .:|    |||.....|...:..::..:.:
Mouse   569 VPSSIQIINYKNISSSSILLYWDPPEYPNG-KITHYTIYAMELDTNRAFQMTTVDNSFLITGLKK 632

  Fly   497 QYYSGYKC-IATNIHG-----TAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLP 555
              |:.||. :|.:.|.     :.|:|:.:   |.|:...|:.|..:..|.::     || ||.|.
Mouse   633 --YTRYKMRVAASTHVGESSLSEENDLFV---RTPEDEPESSPQDVKVTDVS-----PS-ELSLT 686

  Fly   556 ----------ILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGN 610
                      |:||.|.|:   |.|.....|.|   .:...:..|:|.|.|:....:..::|.||
Mouse   687 WSPPEKPNGIIIAYEVFYQ---NADALFVKNTS---TTNITLSDLKPYTLYNISIQSYTRLGHGN 745

  Fly   611 -----WGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQ 670
                 ..|...::.| .||||  ...:..:..::.|...:.|.|.:     |:       |.:|.
Mouse   746 QSSSLLSVRTSETVP-DSAPE--NITYKNISSEEIEIFFLPPRSPN-----GI-------IQKYT 795

  Fly   671 IKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGN----TYYRIELKAHNAIG---YSSPA 728
            |           :.:..|| :....:||||..:|  :|.    |:|.||:.|....|   .|.|.
Mouse   796 I-----------YLKRSNS-HEARTIETTSLTLT--IGGLKKYTHYVIEVSASTLKGEGVRSMPI 846

  Fly   729 SIIMKTTRGIDVIQVAERQVFSSAAIVGIAI----------GGVLL--LLFVVDLLCCITVHMGV 781
            ||:.:     :....:..|.||...:.|:.:          .|::|  .::|.|.:...|::
Mouse   847 SILTE-----EDAPDSPPQNFSVKQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLKTIN--- 903

  Fly   782 MATMCRKAKRSPSEIDDEAKLGSLY---GWRFPLPYCSGQLVKEPPPSPLPLPPP-----VKLGG 838
             ||   :.....|::|..|.. |.|   ..||........::....|...|..||     |.|..
Mouse   904 -AT---EVSLELSDLDYHADY-SAYVTASTRFGDGKTRSSVINFRTPEGEPSDPPKDVHYVNLSS 963

  Fly   839 SPMS---TPLDEKEPLRTPTGSIK------QNSTIEFDGRF 870
            |.:.   ||     |:: |.|.|:      ||::..|...|
Mouse   964 SSIILFWTP-----PVK-PNGIIQYYSVYYQNTSSTFVQNF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	11/54 (20%)
		IG_like	144..226	CDD:214653	16/99 (16%)
		IGc2	152..209	CDD:197706	11/74 (15%)
		I-set	230..319	CDD:254352	26/105 (25%)
		IGc2	243..309	CDD:197706	19/82 (23%)
		IG_like	330..424	CDD:214653	23/132 (17%)
		IGc2	339..412	CDD:197706	20/105 (19%)
		Ig	447..518	CDD:143165	19/89 (21%)
		fn3	534..611	CDD:278470	22/91 (24%)
		FN3	640..735	CDD:238020	25/101 (25%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020
		FN3	308..393	CDD:238020	24/93 (26%)
		fn3	399..>441	CDD:365830	7/42 (17%)
		FN3	570..654	CDD:238020	17/86 (20%)
		fn3	668..744	CDD:365830	21/87 (24%)
		FN3	762..850	CDD:238020	29/115 (25%)
		fn3	857..934	CDD:365830	18/84 (21%)
		FN3	951..1049	CDD:238020	15/54 (28%)
		FN3	1056..1137	CDD:238020
		FN3	1152..1233	CDD:238020
		FN3	1247..1337	CDD:238020
		FN3	1342..1421	CDD:238020
		FN3	1432..1535	CDD:238020
		FN3	1542..1638	CDD:238020
		FN3	1645..1734	CDD:238020
		UP_III_II	1759..1928	CDD:297589
		R-PTPc-Q	2033..2256	CDD:350464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900