DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fas2 and SDK1

DIOPT Version :9

Sequence 1:NP_001284854.1 Gene:Fas2 / 31364 FlyBaseID:FBgn0000635 Length:885 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:739 Identity:184/739 - (24%)
Similarity:267/739 - (36%) Gaps:141/739 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 QRKPV--GKPLILTCRP--TVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALM 102
            |||.|  |:..||...|  :.|.|.:.    |....:..|   |:.|     ...||..:   |:
Human   198 QRKTVSQGRAAILNLLPITSYPRPQVT----WFREGHKII---PSNR-----IAITLENQ---LV 247

  Fly   103 ITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNA-----PENQYPTL----GQDYVVM 158
            |.:.:....|.||..|      :.||....||...|..:.|     ||...||:    |...||.
Human   248 ILATTTSDAGAYYVQA------VNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVA 306

  Fly   159 --------CEVKADP--NPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIE 213
                    |...|.|  :.::.|.|||  :|.|:..:..... |.|.|...:|.|.|.|.||:  
Human   307 GSSETTLECIASARPVEDLSVTWKRNG--VRITSGLHSFGRR-LTISNPTSADTGPYVCEAAL-- 366

  Fly   214 TGELLERTIRVEVFI----------QPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDAT 268
            .|...| ..|...|:          :||     :.:.|...:.....|.|.|.|:|.:.|.:||.
Human   367 PGSAFE-PARATAFLFIIEPPYFTAEPE-----SRISAEVEETVDIGCQAMGVPLPTLQWYKDAI 425

  Fly   269 QLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVL-VRPQIYEL---Y 329
            .::.....|::|....|| .|..:..:|.|.:.|.|.|..|.:...|.|:|. :.|...:.   .
Human   426 SISRLQNPRYKVLASGGL-RIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDT 489

  Fly   330 NVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRI 394
            .||...|  ..:.|...|.|.||||   |..:...........||.:|         ..:|.|:|
Human   490 TVTDGMT--AILRCEVSGAPKPAIT---WKRENHILASGSVRIPRFML---------LESGGLQI 540

  Fly   395 SNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNA 459
            :.....|.|.|.|.|.|.......:..:||.......|..|...|.  :...|.|.|.|...|..
Human   541 APVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPEDHVVI--KGTTATLHCGATHDPRV 603

  Fly   460 TIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSG----YKCIATNIHGTAEHDMQLK 520
            ::.:.|....:.....:..:||.....|.||     .|.:||    |.|...:..|......:|:
Human   604 SLRYVWKKDNVALTPSSTSRIVVEKDGSLLI-----SQTWSGDIGDYSCEIVSEGGNDSRMARLE 663

  Fly   521 EARVP----DFVSEAKPSQLTATTMT----FDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNR 577
            ...:|    :.:.....|...|..::    ||  |.|     |||.|.|:..|..:| |....:.
Human   664 VIELPHSPQNLLVSPNSSHSHAVVLSWVRPFD--GNS-----PILYYIVELSENNSP-WKVHLSN 720

  Fly   578 SWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEP--KPLHNPVQHDKE 640
            .....:...|.||.|...|.||..|.|:||.|.:..    .|.|...||||  .|..|.|...:.
Human   721 VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSA----ETSRLMLPEEPPSAPPKNIVASGRT 781

  Fly   641 EPVVVSPYSDHFELRWGVPAD---NG---EPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETT 699
            ...::        ::|..|.:   ||   ..|.||::...||          |.....:...|..
Human   782 NQSIM--------VQWQPPPETEHNGVLRGYILRYRLAGLPG----------EYQQRNITSPEVN 828

  Fly   700 SFEMTQLVGNTYYRIELKAHNAIG 723
            ...:|.|:..|.|.|::.|:|..|
Human   829 YCLVTDLIIWTQYEIQVAAYNGAG 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fas2NP_001284854.1 IG_like 39..133 CDD:214653 24/94 (26%)
IG_like 144..226 CDD:214653 28/95 (29%)
IGc2 152..209 CDD:197706 19/66 (29%)
I-set 230..319 CDD:254352 24/88 (27%)
IGc2 243..309 CDD:197706 18/65 (28%)
IG_like 330..424 CDD:214653 23/93 (25%)
IGc2 339..412 CDD:197706 19/72 (26%)
Ig 447..518 CDD:143165 17/74 (23%)
fn3 534..611 CDD:278470 26/80 (33%)
FN3 640..735 CDD:238020 19/90 (21%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845 14/66 (21%)
IGc2 312..364 CDD:197706 16/54 (30%)
I-set 386..475 CDD:254352 24/94 (26%)
Ig 404..472 CDD:143165 19/68 (28%)
I-set 480..570 CDD:254352 24/103 (23%)
Ig 494..570 CDD:299845 21/89 (24%)
I-set 575..664 CDD:254352 21/95 (22%)
Ig 580..664 CDD:299845 20/90 (22%)
FN3 668..759 CDD:238020 27/102 (26%)
fn3 771..857 CDD:278470 22/100 (22%)
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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