DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and rig-3

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_509155.1	Gene:	rig-3 / 180958	WormBaseID:	WBGene00004370	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	112/518 - (21%)
Similarity:	185/518 - (35%)	Gaps:	144/518 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 VVMC----EVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAVIETGE 216
            :.||    .|.|..:|:.:   ..:||..:::.....||.:.:|      ||.....:.|.|:.|
Worm    12 LAMCLFVSAVSASDSPSSN---EANPIVISSEAMDYDTNTITVR------EGKKLMVSCVFESDE 67

  Fly   217 LLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVN 281
            .:.::         :::....|...::|:                   .:.:..:|...::...:
Worm    68 QIHKS---------DLLWKQANGNNIDGE-------------------SNPSLFSVILNEKGSKH 104

  Fly   282 PQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKT-KLNVLVRPQIYELYNVTGARTKE-IAITCR 344
            .:|.| ..|||...|.|.|||..:...|...:|| ||.||...:..:...|.||...| |.|.|.
Worm   105 RKTSL-HFSSVHTRDTGLYTCTGRTAGGENFEKTIKLVVLPAIEWNDKDTVKGALLGEPITIDCG 168

  Fly   345 AKGRPA---PAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQ 406
            .|| |:   |.|         :.|||                            |.|..|:.::.
Worm   169 VKG-PSGKEPMI---------QMTNG----------------------------NGEPLDEEIWT 195

  Fly   407 CIARNKGADAYKTGH-------ITVEFAPDFSHMKELP--------------PVFSWEQ------ 444
            ........|:.|..|       ||:|...:.| .:|.|              |.|..|:
Worm   196 IAGNEATIDSLKKEHAELTVSCITIEMHQETS-KEEFPVVDRKDVNIEVYTLPEFETEESVQYTV 259

  Fly   445 -----RKANLSC-LAMGIPNATIEWHWNGR---KIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYS 500
                 |.|.:.| :....|.......::|.   |:.|.::..:. ||....:.|.:|.|......
Worm   260 IDNHVRDAIIYCNVTHSFPPVRHYTFYHGDEEIKMSDKFNIFVN-VGVSQGAHLKIHNVNENDLG 323

  Fly   501 GYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQL--TATTMTFDIRGPSTELGLPILAYSVQY 563
            .|||.|.||...:.|.:.|:||..|   :|.|.:.:  ...::.:.:.....:..||:.|..:::
Worm   324 TYKCEANNIKAKSYHTIHLREANAP---AEPKVTLIEDKRHSIIWKVESIDRDPDLPMTAVEIRH 385

  Fly   564 KEA--------LNPDWSTAYNRSWS--------PDSPYIVEGLRPQTEYSFRFAARNQVGLGN 610
            ..|        .:.|.|.||.:|.|        .|..|.:.|||...||.:||...|:.|.|:
Worm   386 LRAGTAEASGVSDEDISDAYWKSHSIFMQRNIKDDGIYEINGLRHGHEYVWRFRQINEAGFGD 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	15/73 (21%)
		IGc2	152..209	CDD:197706	12/56 (21%)
		I-set	230..319	CDD:254352	18/89 (20%)
		IGc2	243..309	CDD:197706	12/65 (18%)
		IG_like	330..424	CDD:214653	22/104 (21%)
		IGc2	339..412	CDD:197706	14/75 (19%)
		Ig	447..518	CDD:143165	18/74 (24%)
		fn3	534..611	CDD:278470	22/95 (23%)
		FN3	640..735	CDD:238020
rig-3	NP_509155.1	IG_like	48..142	CDD:214653	24/128 (19%)
rig-3	NP_509155.1	Ig	267..341	CDD:319273	18/74 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810