Protein Alignment Fas2 and ncam-1

DIOPT Version :10

• Sequence 1: NP_001284854.1
• Gene: Fas2 / 31364
• FlyBaseID: FBgn0000635
• Length: 885
• Species: Drosophila melanogaster
• Sequence 2: NP_741709.1
• Gene: ncam-1 / 180418
• WormBaseID: WBGene00017184
• Length: 955
• Species: Caenorhabditis elegans
• Alignment Length: 957
• Identity: 204/957 - (21%)
• Similarity: 344/957 - (35%)
• Gaps: 254/957 - (26%)

  Fly    12 FLALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCR-PTVPEPSLVADLQWKDNRNN 75
            ||.|||.   |...|.:.||     .::.:|.:..|...::.|: ......:..|.::|  .|:.
 Worm    37 FLLLLLI---LSGWTLSLSP-----TEERLQNRRSGDNFLVVCKVKDFDGAASDAKIEW--YRDG 91

  Fly    76 TILPKPNGRNQPPMYTETLPGE---SLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVA 137
            .::|:         :..|:..|   |..|||....:..||||.|     .|||..:...:...::
 Worm    92 KLIPR---------FGSTMTIERTYSNQLMINRPKISDGGKYTC-----KTEIQGEQQEVSAEIS 142

  Fly   138 IT----WTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDK-YVVQTNGLLI--- 194
            ..    :.|..|:|:|..|....::|||:......:.|..||..:..|:.: |....|..::
 Worm   143 FVDPPKFLNVQESQHPEEGTRAEIVCEVEGTDQLEVFWQFNGVTLDETSQRGYEFSENNQILYIP 207

  Fly   195 RNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEI--ISLPTNLEAVEGKPFAANCTARGKP 257
            ....:.|:|||.|.||...:.|.|  ::.|..:.:|.|  ..:|.....:||......|.|.|||
 Worm   208 HFTAKKDDGIYNCNAAQYSSFETL--SVNVTGYARPTITVFDVPNGNRGIEGHTIELKCGAVGKP 270

  Fly   258 VPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVR 322
            .|...|..:..::.:|.:|:.  |.:.||:.|.|::.:|.|||.|:|.|..|..::...|.|.::
 Worm   271 KPTYKWFFEDDEVPIARSDKH--NVEEGLLIIESLNSEDAGTYKCVANNTVGSNERTFDLAVFLK 333

  Fly   323 PQIYELYNVTGARTKEIAITCRAKGRPAPAITF----RRWGTQEEYTNGQQDDDPRIILEPNFDE 383
            |::...:........::.:.|...|.......|    ..:..:.|..:....::.|  .|.|..|
 Worm   334 PKVDLKHEYVVKEGDDVELVCSYHGEGHVTAKFVSGHSEFAVRNEAVSAGNSEEIR--PESNESE 396

  Fly   384 ------ERGESTGT---LRISNAE----------RSDDGL------------------------- 404
                  |..|.|.|   :.:.:||          :.|||.
 Worm   397 EVTTTSENSEETSTQDEVELKSAENVNDEEDHTSQQDDGEQDEQEESKKWKRFADDVNNQRISVR 461

  Fly   405 --------------------YQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANL 449
                                |.|...|......|...:.:...|...|... |.:.|::....::
 Worm   462 AEENKLILTIKSISLEDAADYTCAVSNDAGTVNKVTQVGIIHPPTLRHYTG-PHIRSFDGNTVSV 525

  Fly   450 SCLAMGIPNATIEWHW--NGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSG------YKCIA 506
            .|....:|:.  :|||  ||::: :....:::|...|..:.|     |.:.:.|      |.|.|
 Worm   526 YCDVSAVPSP--KWHWFKNGKEV-EANGVSIQIFTQGSSTKL-----TLENFDGSDNFGVYTCRA 582

  Fly   507 TNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRG---------------PSTELGLPI 556
            .|  |..:.:.|:...:|   ||.|.||.:....|.:...|               |.|   :.:
 Worm   583 DN--GVGQLEKQIDVIKV---VSPATPSGMNCKKMVYPNYGKCSFESDIYEKEESKPQT---MEL 639

  Fly   557 LAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPR 621
            |...::..|: :.:||.|...|...:....:..|...|:|..:..|.|:.|...:.......|..
 Worm   640 LVAKLEEMES-DYNWSHAQPVSVPFEDDLTIPNLTSNTQYVIKARAVNEAGSSEYSEEISLETTD 703

  Fly   622 RSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQI-----KYCPG----- 676
            ..||:.|..             |....||:..:.|..|.|:|.|:.::::     ||...
 Worm   704 PWAPQAPGS-------------VAMKCSDYCTVSWDTPNDHGSPLLKFKVTIQEMKYKTDDDEVE 755

  Fly   677 ---------------VKISGTWTELENSCNTVEVME----------------------TTSFE-- 702
                           ...|....|.|.|..::|:.|                      :||.|
 Worm   756 EKSDEKSNNNSEETETTTSDDNDETEASNESIEIKENSEEQETTLAHEDSAEILPTDPSTSVERD 820

  Fly   703 ---------------------MTQLVGNTYYRIELKAHNAIGYSSPASIIMKT-------TRGID 739
                                 :|.:..::||:|.:.|.|..|...||.|..:|       ..|||
 Worm   821 EMVPYGSLLVLNVDSEENQVQLTNIKQHSYYKISVAAENEKGQGEPAEIDFQTDDSPTKYEEGID 885

  Fly   740 VIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHMGVMATMC 786
                      |:..|:.||| |||.||.:|||.|.||...|:::.:|
 Worm   886 ----------STHLIIAIAI-GVLFLLLLVDLGCFITNKCGLISCIC 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	Ig	33..121	CDD:472250	18/91 (20%)
		Ig strand B	50..54	CDD:409353	0/3 (0%)
		Ig strand C	66..70	CDD:409353	0/3 (0%)
		Ig strand E	99..103	CDD:409353	1/3 (33%)
		Ig strand F	113..118	CDD:409353	3/4 (75%)
		Ig	139..209	CDD:472250	19/77 (25%)
		Ig strand B	156..159	CDD:409353	0/2 (0%)
		Ig strand C	168..172	CDD:409353	0/3 (0%)
		Ig strand E	190..194	CDD:409353	1/3 (33%)
		Ig strand F	204..209	CDD:409353	3/4 (75%)
		IgI_4_MYLK-like	229..319	CDD:409568	28/91 (31%)
		Ig strand A	229..232	CDD:409568	1/2 (50%)
		Ig strand A'	238..241	CDD:409568	0/2 (0%)
		Ig strand B	246..254	CDD:409568	1/7 (14%)
		Ig strand C	260..264	CDD:409568	0/3 (0%)
		Ig strand C'	267..270	CDD:409568	0/2 (0%)
		Ig strand D	277..281	CDD:409568	0/3 (0%)
		Ig strand E	285..290	CDD:409568	2/4 (50%)
		Ig strand F	298..306	CDD:409568	5/7 (71%)
		Ig strand G	309..319	CDD:409568	2/9 (22%)
		IG_like	330..424	CDD:214653	21/161 (13%)
		Ig strand B	339..343	CDD:409353	0/3 (0%)
		Ig strand C	352..356	CDD:409353	1/7 (14%)
		Ig strand E	388..394	CDD:409353	2/8 (25%)
		Ig strand F	404..409	CDD:409353	2/49 (4%)
		Ig	447..515	CDD:409353	17/75 (23%)
		Ig strand B	447..451	CDD:409353	0/3 (0%)
		Ig strand C	460..464	CDD:409353	0/3 (0%)
		Ig strand E	487..491	CDD:409353	1/3 (33%)
		Ig strand F	501..506	CDD:409353	3/10 (30%)
		FN3	525..619	CDD:238020	21/108 (19%)
		FN3	640..735	CDD:238020	30/171 (18%)
ncam-1	NP_741709.1	Ig_3	48..127	CDD:464046	21/99 (21%)
		Ig_3	146..222	CDD:464046	19/75 (25%)
		Ig_3	240..317	CDD:464046	25/78 (32%)
		rad2	<378..>465	CDD:273166	14/88 (16%)
		IG_like	<445..499	CDD:214653	4/53 (8%)
		Ig strand E	467..471	CDD:409353	0/3 (0%)
		Ig strand F	481..486	CDD:409353	2/4 (50%)
		Ig strand G	494..497	CDD:409353	1/2 (50%)
		IG_like	520..596	CDD:214653	18/85 (21%)
		Ig strand B	523..527	CDD:409353	0/3 (0%)
		Ig strand C	536..540	CDD:409353	2/3 (67%)
		Ig strand E	561..566	CDD:409353	1/9 (11%)
		Ig strand F	577..582	CDD:409353	2/4 (50%)
		FN3	<652..701	CDD:238020	10/48 (21%)
		FN3	<817..873	CDD:238020	11/55 (20%)