DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	901	Identity:	244/901 - (27%)
Similarity:	382/901 - (42%)	Gaps:	101/901 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLLCSCSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNTI 77
            ::|||....|..|.|:...:|::..........||:....|| ..:.||.   .:.|.:.:...|
Mouse     1 MSLLLSFYLLGLLVRSGQALLQVTISLSKVELSVGESKFFTC-TAIGEPE---SIDWYNPQGEKI 61

  Fly    78 LPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTN 142
            :     ..|..|..:  .|....|.|.:.::|..|.|.|.|:.|..:..|..|.::.|..:|:..
Mouse    62 I-----STQRVMLQK--EGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFRE 119

  Fly   143 APENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDK--YVVQTNGLLIRNVQESDEGIY 205
            ....|....|:|..|:|.|.:.|.|.:.||.:.:.:.|..|.  .|:..|.|.|.|:.:||||||
Mouse   120 VVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIPDNRFAVLANNNLQILNINKSDEGIY 184

  Fly   206 TCRAAVIETGELLERTIRVEVFIQPEIISLPT---NLEAVEGKPFAANCTARGKPVPEISWIRDA 267
            .|...|...||:..|.|.|.|.:.|.|: :|.   |..|..|:.....|.|.|.|.|.|||.|:.
Mouse   185 RCEGRVEARGEIDFRDIIVIVNVPPAIM-MPQKSFNATAERGEEMTLTCKASGSPDPTISWFRNG 248

  Fly   268 TQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVT 332
            ..  :...:::.:......:|:.::...|.|:|.|.|.|:||...::..|.|.|:|.|.:|.|.|
Mouse   249 KL--IEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNET 311

  Fly   333 GARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGE-STGTLRISN 396
            .:....:.:.|.|:|.|.|.||::|......::.|.:..|.||       |.:|: ...:|.|.:
Mouse   312 TSENGHVTLVCEAEGEPVPEITWKRAIDGVMFSEGDKSPDGRI-------EVKGQHGRSSLHIRD 369

  Fly   397 AERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKANLSCLAMGIPNATI 461
            .:.||.|.|.|.|.::.....::.|:.:|:||.|...:.:  .:|||....|:||.....|.|:|
Mouse   370 VKLSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTM--YYSWEGNPINISCDVTANPPASI 432

  Fly   462 EWHWNGRKI----KDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEA 522
              ||...|:    |:  .|:||....|.:..|.:.|.:...:..|.|.|||..||...:..|:.|
Mouse   433 --HWRREKLLLPAKN--TTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELA 493

  Fly   523 RVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIV 587
            .||......|..:|:.||.......|.:..|:||..|.|..||..:..|...  ||....:..::
Mouse   494 DVPSSPHGVKIIELSQTTAKISFNKPESHGGVPIHHYQVDVKEVASETWKIV--RSHGVQTMVVL 556

  Fly   588 EGLRPQTEYSFRFAARNQVGLGNWG-VNQQQSTPRRSAPEEPKP--LHNPVQHDKEEPVVVSPYS 649
            ..|.|.|.|..|.||.|..|.|::. :...|:.|.|    ||.|  :|......|...:.::...
Mouse   557 SSLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVR----EPSPPSIHGQPSSGKSFKISITKQD 617

  Fly   650 DHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRI 714
                       |.|.||..|.:||....| ...|.|.:...|...::      :..|.....|.:
Mouse   618 -----------DGGAPILEYIVKYRSKDK-EDQWLEKKVQGNKDHII------LEHLQWTMGYEV 664

  Fly   715 ELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHM 779
            ::.|.|.:|||.|...........::|:..........||:|:.:..:||:|.|.|:.|......
Mouse   665 QITAANRLGYSEPTVYEFSMPPKPNIIKDTLFNGLGLGAIIGLGVAALLLILVVTDVSCFFIRQC 729

  Fly   780 GVMATMCRK--AKRSPS-----EIDDEAKLGSLY-GWRFPL-----------PYCSGQLVKEPPP 825
            |::..:.|:  .|:|.|     |: :|.|...|. |.:.|:           .:..|..|.||..
Mouse   730 GLLMCITRRMCGKKSGSSGKSKEL-EEGKAAYLKDGSKEPIVEMRTEDERITNHEDGSPVNEPNE 793

  Fly   826 SPLPLPPPVKLGGSPMSTPLDE---KEPLRTPTGSIKQNSTIEFDGRFVHSRSGEI 878
            : .||..|.||       ||.|   ||.|...|..||.::.|      :.|:..:|
Mouse   794 T-TPLTEPEKL-------PLKEENGKEVLNAETIEIKVSNDI------IQSKEDDI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	21/93 (23%)
		IG_like	144..226	CDD:214653	30/83 (36%)
		IGc2	152..209	CDD:197706	23/58 (40%)
		I-set	230..319	CDD:254352	25/91 (27%)
		IGc2	243..309	CDD:197706	17/65 (26%)
		IG_like	330..424	CDD:214653	25/94 (27%)
		IGc2	339..412	CDD:197706	22/73 (30%)
		Ig	447..518	CDD:143165	23/74 (31%)
		fn3	534..611	CDD:278470	24/76 (32%)
		FN3	640..735	CDD:238020	19/94 (20%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	22/101 (22%)
		I-set	22..111	CDD:254352	21/99 (21%)
		I-set	117..193	CDD:254352	25/75 (33%)
		IGc2	128..189	CDD:197706	23/60 (38%)
		Ig	208..301	CDD:299845	26/95 (27%)
		I-set	215..298	CDD:254352	22/84 (26%)
		Ig	300..397	CDD:299845	29/103 (28%)
		IG_like	308..395	CDD:214653	24/93 (26%)
		IG_like	413..491	CDD:214653	25/81 (31%)
		IGc2	414..482	CDD:197706	22/71 (31%)
		FN3	496..588	CDD:238020	26/93 (28%)
		fn3	594..678	CDD:278470	22/101 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810		14/53 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3056
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm43641
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4566
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.770