DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and rig-4

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	1025	Identity:	209/1025 - (20%)
Similarity:	355/1025 - (34%)	Gaps:	283/1025 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VGKPLILTCRPT-VPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVE 109
            ||:..:|. ||| :...:|.....|..:.::.:.|...       :..|..|.   |::|.:..:
Worm   133 VGRYFVLR-RPTLLASRNLDISYSWIKDDSHQVTPDAT-------HFVTSDGN---LVVTGVKRD 186

  Fly   110 MGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPEN-------------QYP--------TLGQ 153
            ..|.|...||..:.    |.:..|.|      |..:|             .:|        ||..
Worm   187 DFGAYKLMASSDDL----KEIVSKEY------NVRDNGLSPSLQNTLSIVYFPTDRTIIESTLPH 241

  Fly   154 DYVVMCEVK--ADPNPTIDWLRNGDPIRTTNDKYVVQTNG--LLIRNVQESDEGIY--TCR--AA 210
            |.:..|...  :..:..|.|..||..|..:........|.  |:|.|......|.:  .||  ||
Worm   242 DEIFDCVTSFGSKDDVRIRWFLNGQQISGSEVGMTTTLNNRRLIISNPSSFTRGEHKLECRADAA 306

  Fly   211 VIETGELLERTIRVEVFIQPEIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATA 275
            :..|.:  :::..:....:|.:..||..::...|...:..|:.:.|...:|.|.::...:..
Worm   307 MGRTSD--QKSAYMTFISRPILKDLPNEIQKTVGSSLSLKCSVKKKSSMDIKWYKNGLMMTT--- 366

  Fly   276 DRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAG-----VVDQKTKLNVLVRPQIYE-------- 327
                   |.|.:||..:.|||:|.|.|.|.|.||     |..::.:.|..|..::.|
Worm   367 -------QRGKLTIDRIKQDDFGLYQCEATNAAGADLASVWVKEGEANETVATEMSEDGMSLEEE 424

  Fly   328 ----------------------LYNVT------------------GARTKEIAITCRAKGRPAPA 352
                                  |:..|                  .:.|..|.:.|.|.|.|.|.
Worm   425 ISMETPPPRKLKFFDNSKSQEQLFPFTSELEPSQKLIKTPKDLTVASGTDRIMMECAATGSPPPN 489

  Fly   353 ITFRRWGTQEEYTNGQ--QDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGAD 415
            |.   |     ..||.  |.|:.:..|          :...|.|.:..:||:|.|.|  ...|::
Worm   490 II---W-----LLNGHEIQTDNVKYDL----------TNDGLAIHDIRKSDEGEYTC--EISGSN 534

  Fly   416 AYKTGHITV------EFAPDFSHMKELPPV---FSWEQRKANLSCLAMGIPNATIEWHWNGRKIK 471
            ...|.::.|      |:.|  :..|.|...   ||.|..|..       :..|::||:.|...:.
Worm   535 VKATANVQVNGDSLIEYGP--ADQKSLIGTNVEFSCEVAKEY-------VRKASVEWYLNDVLLP 590

  Fly   472 DLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQL 536
            ...::.|:| ....:..||:..|.......|:|..| :.|..|:...:.:......:.|...::|
Worm   591 VNGNSGLRI-SRNRKGSLIIRQVGPDNTGEYRCRVT-VDGREENASAMLQIIEKPAMPERVRAEL 653

  Fly   537 TATTMTFDIRGPSTELGL----PILAYSVQYKEALNP-----DWSTAYNR---------SWSPDS 583
            ...||...:|....| |.    ||:.::::.: .:.|     ||:||.:.         .|:.
Worm   654 HNETMPAKVRVRWNE-GFDGNEPIIKHAIEMR-TMGPTGLWSDWTTAIDNIPKEEGKPCCWTD-- 714

  Fly   584 PYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSA--PEEPKPLHNPVQHDKEEPVVVS 646
               :|.|||.:...||..|.|:.|.|      :.|.|..|.  |::| |...|      ..|..|
Worm   715 ---IEDLRPSSTAEFRVVASNKHGPG------KPSLPSYSVTMPQQP-PSAAP------RNVAAS 763

  Fly   647 PYSDH-FELRWGVP---ADNGEPIDRYQIKYCPGVKISG----TWTELENSCNTVEVMETTSFEM 703
            ..|.| ..::|..|   .|:|:.:. |.::|    :::|    ||.  |.:..|.:...|.   :
Worm   764 ARSPHSVMVQWQQPKEELDSGDVLG-YVVRY----RLAGYSSLTWN--EKNLTTKDARNTL---V 818

  Fly   704 TQLVGNTYYRIELKAHNAIG---YSSPASIIMKTTRGIDVIQVAERQVFSSAAIV---------- 755
            .:|:....|.|::.|:|..|   :|....:.....|.....:....:|.:|.|:.
Worm   819 DELITWREYEIQVAAYNKRGLGVFSESIEVTTSEGRPTQAPKNVRVKVLNSTAVAIEFTAPEQQR 883

  Fly   756 --GIAIG------------GVLLLLFVVD----------------------LLCCITVHMGVMAT 784
              |:.:|            |.|....::|                      .||..|...|..:.
Worm   884 IPGVNLGYKVQFWKGEPEKGELYKQVILDPDRRQLTTVVNELEKFGHYNLTTLCFTTPGDGPRSN 948

  Fly   785 MCR--KAKRSPSEIDDEAKL-----GSLYGWRFPLPYCSGQLVKEPPPSPLPLPPPVK----LGG 838
            :.:  ..:.:|..:|:.:..     |::..|..||.. :|.:.|..........|.||    :.|
Worm   949 VVKVVTEEDTPESVDELSIAEVMYNGAVITWNSPLKQ-NGIVTKYTIRHWAASSPDVKTKHEVDG 1012

  Fly   839 SPMSTPLDEKEPLRTPTGSIKQNSTIEFDG-----RFVHSRSGEIIGKNS 883
            |..:..:|..:| .|..|.....||.:.||     :|......|:.|:.|
Worm  1013 STTNFTIDGLQP-STRYGVDVMASTRKGDGPVEETKFESGVPPELPGRPS 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	18/87 (21%)
		IG_like	144..226	CDD:214653	21/110 (19%)
		IGc2	152..209	CDD:197706	14/64 (22%)
		I-set	230..319	CDD:254352	23/93 (25%)
		IGc2	243..309	CDD:197706	17/65 (26%)
		IG_like	330..424	CDD:214653	24/113 (21%)
		IGc2	339..412	CDD:197706	20/74 (27%)
		Ig	447..518	CDD:143165	14/70 (20%)
		fn3	534..611	CDD:278470	24/94 (26%)
		FN3	640..735	CDD:238020	23/105 (22%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653	21/81 (26%)
		IGc2	338..393	CDD:197706	17/64 (27%)
		I-set	459..543	CDD:254352	23/103 (22%)
		IGc2	478..534	CDD:197706	20/75 (27%)
		IG_like	553..639	CDD:214653	21/96 (22%)
		Ig	564..635	CDD:143165	18/79 (23%)
		FN3	643..747	CDD:238020	28/116 (24%)
		FN3	756..850	CDD:238020	24/109 (22%)
		FN3	858..954	CDD:238020	12/95 (13%)
		FN3	959..1042	CDD:238020	20/84 (24%)
		FN3	1057..1151	CDD:238020	2/5 (40%)
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I7441
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900