DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and lad-2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001023496.1	Gene:	lad-2 / 177078	WormBaseID:	WBGene00002243	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	786	Identity:	178/786 - (22%)
Similarity:	284/786 - (36%)	Gaps:	157/786 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LEIYPKQEVQ--RKPVGKPLILTCRPT--VPEPSLVADLQW--KDNRNNTILPKPNGRNQPPMYT 91
            ||.:||::|:  |...|:.|.|.|.|.  .|:|.:|    |  :...:::::.....|:
Worm   125 LEHFPKRDVKLLRVKEGESLTLNCTPPRGTPDPKIV----WLYRSLDDSSVIETIRSRH------ 179

  Fly    92 ETLPGESLALMITSLSVEMG-GK----YYCTAS-------YANTEILEKGV---TIKTYVAITWT 141
            .|:..|.   .:...|||:. ||    |.|.|:       |.:.:.::..:   ..|::.....:
Worm   180 ITVDNEG---HLHFSSVELSDGKATLVYECAATSPVLRGEYRSGDRIQLDIEPSQDKSHPVKKMS 241

  Fly   142 NAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDKYVVQ-----TNGLLIRNVQESD 201
            .:|.......|....:.|.....|.|||.|.:....:..:..|.:..     ...|::.||...|
Worm   242 VSPSEVTVRAGGQLKLQCIFGGRPLPTIFWSKIDGELPKSRIKDLTSHESDFGRSLIVENVHPDD 306

  Fly   202 EGIYTCRAAVIETGELLERTIRVEV-------FIQPEIISLPTNLEAVEGKPFAANCTARGKPVP 259
            .|.|.||      |..|..|:.|.|       |..|..||||   |...|:   ..|.|.|:|.|
Worm   307 AGAYECR------GRHLVHTVNVRVMAAPFWEFDPPRDISLP---EESTGE---LECLAGGQPTP 359

  Fly   260 EISWIRDATQLNVATADRFQVNPQTG-LVTISSVSQD-DYGTYTCLAKNRAGVVDQKTKLNVLVR 322
            .|:|..:...|:....|..:|....| ::.:.:::.| |.|.|.|.|.|..|.|.....::|...
Worm   360 IITWSMNGKFLHELAEDSRRVLLDHGRILRVRNLNHDLDTGVYQCNASNPLGYVFANAFVHVRAH 424

  Fly   323 PQIYELYNVTGAR------TKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILE--- 378
            ...:.:   ..||      ...:.:.|.....|...:   ||        ...||.|..::|
Worm   425 APFFRM---PAARHWKVVLHSTVVLDCDVDAAPEAMV---RW--------VDADDRPLQVVEGKN 475

  Fly   379 ---PNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVF 440
               ||.         |..:.:...:|:|||.|...||......|..:.| |.|.:......|...
Worm   476 KLFPNH---------TFMVYDVNSADEGLYYCNVSNKYGINRATNRLQV-FKPTYFVRIPTPKRL 530

  Fly   441 SWEQ-RKANLSCLAMGIPNATIEWHW--NGRKIKD--LYDTNLKIVGTGPRSDLIVHPVTRQYYS 500
            ..|. ..|.:.|.|:..|...|.:.|  ||:.:.:  .|:.         ..|.:.....|..:|
Worm   531 ILEAGETAEVFCEAVADPRLPIRYQWTINGKVLTESQYYEI---------LPDRLRFRSVRGRHS 586

  Fly   501 G-YKCIATNIHGTAEHDMQL--KEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQ 562
            | ..|.|..........|||  |:......|..|..|:..||....    .:::.|..|..|.|:
Worm   587 GIIDCAAITDVDVKLASMQLIVKDVPAHPVVETAHCSERKATVKWV----AASDHGDSIKKYIVE 647

  Fly   563 -YKEALNPDWSTAYNRSWSPDSPYIVE-GLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAP 625
             :.:....:|.............:.|: .|.|...|:||..|.|..|..:..::.|......:..
Worm   648 MFTDFKKNEWEVINEEVNVNKETFEVDITLTPWVNYTFRVVAVNSHGRSDMKIDGQPKEDWLTCQ 712

  Fly   626 EEPK-PLHNP--VQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQ---------IKYCPGVK 678
            ..|. |..||  |:.:..||       |:..:.|       :|:|||.         ::|.....
Worm   713 TRPSFPYTNPTGVKGEGTEP-------DNLVISW-------KPLDRYYWNAPNMQYLVRYKLDEP 763

  Fly   679 ISGTWTE--LENS-CNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDV 740
            |.| |||  :|:| .|...:.:..:|..        |.|::::.|::|.|.....|.....|.||
Worm   764 IHG-WTEFLVEDSLANFTIIRDQPTFRK--------YLIQVQSVNSVGPSIVEPEIHHGWSGEDV 819

  Fly   741 IQVAER 746
            ...|.|
Worm   820 PDEAPR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	23/114 (20%)
		IG_like	144..226	CDD:214653	21/86 (24%)
		IGc2	152..209	CDD:197706	15/61 (25%)
		I-set	230..319	CDD:254352	27/90 (30%)
		IGc2	243..309	CDD:197706	19/67 (28%)
		IG_like	330..424	CDD:214653	21/105 (20%)
		IGc2	339..412	CDD:197706	16/78 (21%)
		Ig	447..518	CDD:143165	15/75 (20%)
		fn3	534..611	CDD:278470	17/78 (22%)
		FN3	640..735	CDD:238020	24/106 (23%)
lad-2	NP_001023496.1	IG_like	48..116	CDD:214653
		Ig	49..121	CDD:299845
		Ig	124..214	CDD:299845	26/101 (26%)
		IG_like	244..325	CDD:214653	21/86 (24%)
		Ig	255..325	CDD:299845	19/75 (25%)
		I-set	335..421	CDD:254352	27/91 (30%)
		Ig4_L1-NrCAM_like	344..422	CDD:143179	21/80 (26%)
		IG_like	438..515	CDD:214653	19/96 (20%)
		Ig	443..516	CDD:299845	20/93 (22%)
		IG_like	527..608	CDD:214653	20/89 (22%)
		Ig	535..>593	CDD:299845	14/66 (21%)
		FN3	610..697	CDD:238020	19/90 (21%)
		FN3	721..804	CDD:238020	25/105 (24%)
		fn3	823..909	CDD:278470	2/3 (67%)
		FN3	921..1010	CDD:238020
		FN3	1016..1108	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910