DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and zig-8

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_499714.1	Gene:	zig-8 / 176732	WormBaseID:	WBGene00006985	Length:	268	Species:	Caenorhabditis elegans

Alignment Length:	180	Identity:	38/180 - (21%)
Similarity:	70/180 - (38%)	Gaps:	46/180 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 CEVKADPNPTIDWLR--------NGDPIRTTNDKYVVQTNG-----LLIRNVQESDEGIYTCRAA 210
            |.|..|....|.|.|        .|:...|.:.::.|....     |.:|..::.|.|.|.|
Worm    57 CSVPPDAEHEIAWTRVSDGALLTAGNRTFTRDPRWQVSKKSANIWVLNLRRAEQQDSGCYLC--- 118

  Fly   211 VIETGELLER-----TIRVEVFIQPEIISLPTNLEA--------VEGKPFAANCTA----RGKPV 258
                 |:.::     .:.::| ::|.:.| |::|:.        :.|.....|||.    :.:.|
Worm   119 -----EINDKHNTVYAVYLKV-LEPPLPS-PSSLQKKSTKLMANMSGDEVVLNCTVTSTDKDEEV 176

  Fly   259 PEISWIRDATQLNVATADRF--QVNPQTGLV----TISSVSQDDYGTYTC 302
            .::.|.||...:|....:::  :|....|:|    .|...:.:|.|.|.|
Worm   177 LDVVWTRDGNTINFNDTEKYILKVKRDAGVVIETMRIRKATMEDDGNYAC 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	16/84 (19%)
		IGc2	152..209	CDD:197706	15/62 (24%)
		I-set	230..319	CDD:254352	21/91 (23%)
		IGc2	243..309	CDD:197706	17/70 (24%)
		IG_like	330..424	CDD:214653
		IGc2	339..412	CDD:197706
		Ig	447..518	CDD:143165
		fn3	534..611	CDD:278470
		FN3	640..735	CDD:238020
zig-8	NP_499714.1	IG_like	55..134	CDD:214653	16/84 (19%)
		Ig	55..129	CDD:143165	16/79 (20%)
		ig	158..229	CDD:278476	17/69 (25%)
		IG_like	158..227	CDD:214653	17/69 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900