DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Dscam

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	192/774 - (24%)
Similarity:	311/774 - (40%)	Gaps:	132/774 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 KPLILTCR-PTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLA-LMITSLSVEM 110
            :|:.|.|. ...|.|::...|.     ::.|| |.:|.....|.|.  .|..:: |.|:|..|..
  Rat   422 EPVSLVCNVKGTPLPTVTWTLD-----DDPIL-KGSGHRISQMITS--EGNVVSYLNISSSQVRD 478

  Fly   111 GGKYYCTA-SYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRN 174
            ||.|.||| :.|...:.:..:.::...:|   ...:|.....|:|..:.|.|...|..:|.|.:|
  Rat   479 GGVYRCTANNSAGVVLYQARINVRGPASI---RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKN 540

  Fly   175 GDPIRTTNDKYVVQTNGLL-IRNVQ-ESDEGIYTCRAAV---IETGELLERTIRVEVFIQP---- 230
            .:.:...:.:...:.||.| :.:|| |.|||.|||...|   :.|.:.:..|::|..||||
  Rat   541 ANLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605

  Fly   231 -----EIISLPTNLEAVEGK-PFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTI 289
                 :.:.:|  ...|.|. |........|:|:|        ..|.| |.|....   |..:.|
  Rat   606 RFSIGQRVFIP--CVVVSGDLPITITWQKDGRPIP--------ASLGV-TIDNIDF---TSSLRI 656

  Fly   290 SSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQ-IYELYNVTGARTKEIAITCRAKGRPAPAI 353
            |::|....|.|||:|:|.|..|:.:::|.|.|.|: :.:..:..|...|.:.:.|.|:|.|.|.|
  Rat   657 SNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTI 721

  Fly   354 TFRRWGTQEEYTNGQQDDDPRIILEPNFD--EERGE----STGTLRISNAERSDDGLYQC-IARN 411
            .::       ::.|..        .|.|.  ...|.    |.|:|.|.:....|.|.|.| ::.:
  Rat   722 VWK-------FSKGAG--------VPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSND 771

  Fly   412 KGADAYKTGHITVEFAPDFSHMKELP-PVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKD--- 472
            .|||..|:.::||:..   :.:...| ...:.:.::..:||.|.|.....:.|....|.|..
  Rat   772 VGADVSKSMYLTVKIP---AMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833

  Fly   473 LYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD----FVSEAKP 533
            .|..:.|.||....|.|.:.|..|:....:.|.|.|.:|.....:||.....||    .:.:.|.
  Rat   834 RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKA 898

  Fly   534 SQLTAT-TMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAY-NRSWSP--DSPYIVEGLRPQT 594
            ..:|.. ||.||  |.|     ||..|.::.|.. :..|.:|. .:..||  :|..|:: :.|.:
  Rat   899 RTITLRWTMGFD--GNS-----PITGYDIECKNK-SDSWDSAQRTKDVSPQLNSATIID-IHPSS 954

  Fly   595 EYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVP 659
            .||.|..|:|::|... ..|:...|...:||:      .|.|....||.    .|....:.|..|
  Rat   955 TYSIRMYAKNRIGKSE-PSNEITITADEAAPD------GPPQEVHLEPT----SSQSIRVTWKAP 1008

  Fly   660 ---ADNGEPIDRYQIKYCPGVKISGTWTELENSCN---TVEVMETTS----FEMTQLVGNTYYRI 714
               ..|| .|..|||.|          .|.....|   .:..::||.    :.:..|...|.|.:
  Rat  1009 KKHLQNG-IIRGYQIGY----------REYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGL 1062

  Fly   715 ELKAHNAIGYSSPASIIMKTT---------RGIDVIQVAERQV-FSSAAIVGIAIGGVL 763
            .::|.|..|....:..|:.||         ..:..|..:...: .|.:.:...|:.|:|
  Rat  1063 VVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGIL 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/87 (28%)
		IG_like	144..226	CDD:214653	25/86 (29%)
		IGc2	152..209	CDD:197706	20/58 (34%)
		I-set	230..319	CDD:254352	25/98 (26%)
		IGc2	243..309	CDD:197706	19/66 (29%)
		IG_like	330..424	CDD:214653	24/100 (24%)
		IGc2	339..412	CDD:197706	18/79 (23%)
		Ig	447..518	CDD:143165	19/73 (26%)
		fn3	534..611	CDD:278470	24/80 (30%)
		FN3	640..735	CDD:238020	23/104 (22%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386	24/86 (28%)
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353	3/8 (38%)
		Ig strand C	436..442	CDD:409353	1/5 (20%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	452..460	CDD:409353	2/7 (29%)
		Ig strand E	464..473	CDD:409353	2/8 (25%)
		Ig strand F	480..488	CDD:409353	5/7 (71%)
		Ig strand G	491..501	CDD:409353	0/9 (0%)
		Ig	504..593	CDD:416386	24/91 (26%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	1/3 (33%)
		Ig strand B	519..526	CDD:409353	1/6 (17%)
		Ig strand C	533..539	CDD:409353	2/5 (40%)
		Ig strand C'	540..542	CDD:409353	1/1 (100%)
		Ig strand D	549..553	CDD:409353	0/3 (0%)
		Ig strand E	557..563	CDD:409353	2/5 (40%)
		Ig strand F	571..579	CDD:409353	4/7 (57%)
		Ig strand G	583..593	CDD:409353	1/9 (11%)
		Ig	596..686	CDD:416386	28/103 (27%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand B	611..620	CDD:409353	1/10 (10%)
		Ig strand C	625..632	CDD:409353	1/6 (17%)
		Ig strand C'	634..636	CDD:409353	1/1 (100%)
		Ig strand D	643..648	CDD:409353	3/5 (60%)
		Ig strand E	651..658	CDD:409353	2/6 (33%)
		Ig strand F	665..673	CDD:409353	5/7 (71%)
		Ig strand G	676..685	CDD:409353	1/8 (13%)
		Ig_DSCAM	689..784	CDD:409397	25/109 (23%)
		Ig strand B	707..711	CDD:409397	0/3 (0%)
		Ig strand C	720..724	CDD:409397	1/3 (33%)
		Ig strand E	749..753	CDD:409397	2/3 (67%)
		Ig strand F	763..768	CDD:409397	2/4 (50%)
		Ig strand G	777..780	CDD:409397	1/2 (50%)
Ig_DSCAM	785..884	CDD:409398	22/101 (22%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	0/3 (0%)
Ig strand E	848..852	CDD:409398	2/3 (67%)
Ig strand F	862..867	CDD:409398	1/4 (25%)
Ig strand G	875..878	CDD:409398	0/2 (0%)
FN3	885..978	CDD:238020	28/102 (27%)
FN3	986..1083	CDD:238020	25/111 (23%)
FN3	1091..1184	CDD:238020	5/31 (16%)
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900