DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and Il1rap

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	NP_001152790.1	Gene:	Il1rap / 16180	MGIID:	104975	Length:	685	Species:	Mus musculus

Alignment Length:	625	Identity:	124/625 - (19%)
Similarity:	200/625 - (32%)	Gaps:	231/625 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 YCTASYANTEILEKGVTI---------KTYV-----AITWTNAPENQYPTLGQDYVVMCEVKADP 165
            ||:......|:::|....         |.|:     .||..|. :..:|:         .||
Mouse   121 YCSKVAFPLEVVQKDSCFNSAMRFPVHKMYIEHGIHKITCPNV-DGYFPS---------SVK--- 172

  Fly   166 NPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQ-----ESDEGIYTCRAAVIETGEL--LERTIR 223
             |::.|.:....|   .|.:.|...|:   |:.     .|:.|.|||.....|.|.|  |.||:.
Mouse   173 -PSVTWYKGCTEI---VDFHNVLPEGM---NLSFFIPLVSNNGNYTCVVTYPENGRLFHLTRTVT 230

  Fly   224 VEVF------IQPEIISLPTNLEAVEGKPFAANCTARGKP--VP-------------EISWIRDA 267
            |:|.      :.|:|.| |.:....|.:|        |:.  :|             |:.|..|.
Mouse   231 VKVVGSPKDALPPQIYS-PNDRVVYEKEP--------GEELVIPCKVYFSFIMDSHNEVWWTIDG 286

  Fly   268 TQLNVATADRFQVN-----------PQTGLVTISSVSQDDY-GTYTCLAKNRAGVVDQKTKLNVL 320
            .:.:..|.| ..:|           .:|.:::|..|:.:|. ..|.|.|:|..|..:|..|:...
Mouse   287 KKPDDVTVD-ITINESVSYSSTEDETRTQILSIKKVTPEDLRRNYVCHARNTKGEAEQAAKVKQK 350

  Fly   321 VRPQIY--ELYNVTGART--------------KEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQ 369
            |.|..|  ||....||..              .|:.:..||           .:||.|...:| :
Mouse   351 VIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRA-----------HFGTDETILDG-K 403

  Fly   370 DDDPRIILEPNFDEE-------RG--ESTGTLRISNAERSD-------DGLYQCIARNKG----- 413
            :.|..:....|.:||       ||  |:....::...:|..       :.::..|.|::.
Mouse   404 EYDIYVSYARNVEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGNTVEAVFDFIQRSRRMIVVL 468

  Fly   414 ---------------------ADAYKTGHITVEFA------PDFSHMKELPPVFSWEQRKANLS- 450
                                 .::..|..|.||:.      |....:||.....||:..|:..|
Mouse   469 SPDYVTEKSISMLEFKLGVMCQNSIATKLIVVEYRPLEQPHPGIMQLKESVSFVSWKGEKSKHSG 533

  Fly   451 -------CLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATN 508
                   .||:.:.:.:....||              .....:||:.:..|.|:
Mouse   534 SKFWKALRLALPLRSLSASSGWN--------------ESCSSQSDISLDHVQRR----------- 573

  Fly   509 IHGTAEHDMQLK---EARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILA--YSVQYKEA-- 566
                    .:||   |.|..:.||.|:|:..|.          |...|.|..|  ..|.|.|.
Mouse   574 --------SRLKEPPELRSSERVSGAEPAPGTM----------SKHRGKPSAACRCCVTYCEGES 620

  Fly   567 -----------LNPDWSTAYNRS--WSPDSPYIVEGLRPQ 593
                       .:|.|.|...:.  ...:|.:|..|.||:
Mouse   621 HLRSKSRAEMHTHPQWETHLCKPPLQESESQWIQNGTRPE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	4/26 (15%)
		IG_like	144..226	CDD:214653	22/88 (25%)
		IGc2	152..209	CDD:197706	14/61 (23%)
		I-set	230..319	CDD:254352	25/115 (22%)
		IGc2	243..309	CDD:197706	18/92 (20%)
		IG_like	330..424	CDD:214653	21/149 (14%)
		IGc2	339..412	CDD:197706	16/88 (18%)
		Ig	447..518	CDD:143165	9/78 (12%)
		fn3	534..611	CDD:278470	16/77 (21%)
		FN3	640..735	CDD:238020
Il1rap	NP_001152790.1	Ig1_IL1R_like	25..132	CDD:409584	3/10 (30%)
		Ig strand B	43..47	CDD:409584
		Ig strand C	67..71	CDD:409584
		Ig strand E	97..101	CDD:409584
		Ig strand F	111..116	CDD:409584
		Ig strand G	124..127	CDD:409584	0/2 (0%)
		Ig	145..235	CDD:416386	28/109 (26%)
		Ig strand A	145..150	CDD:409353	1/4 (25%)
		Ig strand A	145..150	CDD:409353	1/4 (25%)
		Ig strand B	156..160	CDD:409353	1/3 (33%)
		Ig strand B	156..160	CDD:409353	1/3 (33%)
		Ig strand C	174..179	CDD:409353	1/4 (25%)
		Ig strand C	174..179	CDD:409353	1/4 (25%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand C'	182..184	CDD:409353	0/1 (0%)
		Ig strand D	189..193	CDD:409353	1/3 (33%)
		Ig strand D	189..193	CDD:409353	1/3 (33%)
		Ig strand E	195..200	CDD:409353	1/7 (14%)
		Ig strand E	195..200	CDD:409353	1/7 (14%)
		Ig strand F	209..218	CDD:409353	3/8 (38%)
		Ig strand F	209..218	CDD:409353	3/8 (38%)
		Ig strand G	221..234	CDD:409353	5/12 (42%)
		Ig strand G	221..234	CDD:409353	5/12 (42%)
		Ig3_IL1RAP	243..349	CDD:409525	25/115 (22%)
		Ig strand B	262..266	CDD:409525	0/3 (0%)
		Ig strand C	279..283	CDD:409525	1/3 (33%)
		Ig strand E	314..318	CDD:409525	0/3 (0%)
		Ig strand F	329..334	CDD:409525	2/4 (50%)
		Ig strand G	341..344	CDD:409525	0/2 (0%)
		TIR	404..547	CDD:214587	23/142 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000