DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and Dscam

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	774	Identity:	192/774 - (24%)
Similarity:	311/774 - (40%)	Gaps:	132/774 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 KPLILTCR-PTVPEPSLVADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLA-LMITSLSVEM 110
            :|:.|.|. ...|.|::...|.     ::.|| |.:|.....|.|.  .|..:: |.|:|..|..
Mouse   422 EPVSLVCNVKGTPLPTVTWTLD-----DDPIL-KGSGHRISQMITS--EGNVVSYLNISSSQVRD 478

  Fly   111 GGKYYCTA-SYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRN 174
            ||.|.||| :.|...:.:..:.::...:|   ...:|.....|:|..:.|.|...|..:|.|.:|
Mouse   479 GGVYRCTANNSAGVVLYQARINVRGPASI---RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKN 540

  Fly   175 GDPIRTTNDKYVVQTNGLL-IRNVQ-ESDEGIYTCRAAV---IETGELLERTIRVEVFIQP---- 230
            .:.:...:.:...:.||.| :.:|| |.|||.|||...|   :.|.:.:..|::|..||||
Mouse   541 ANLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605

  Fly   231 -----EIISLPTNLEAVEGK-PFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVTI 289
                 :.:.:|  ...|.|. |........|:|:|        ..|.| |.|....   |..:.|
Mouse   606 RFSIGQRVFIP--CVVVSGDLPITITWQKDGRPIP--------ASLGV-TIDNIDF---TSSLRI 656

  Fly   290 SSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQ-IYELYNVTGARTKEIAITCRAKGRPAPAI 353
            |::|....|.|||:|:|.|..|:.:::|.|.|.|: :.:..:..|...|.:.:.|.|:|.|.|.|
Mouse   657 SNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTI 721

  Fly   354 TFRRWGTQEEYTNGQQDDDPRIILEPNFD--EERGE----STGTLRISNAERSDDGLYQC-IARN 411
            .::       ::.|..        .|.|.  ...|.    |.|:|.|.:....|.|.|.| ::.:
Mouse   722 VWK-------FSKGAG--------VPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSND 771

  Fly   412 KGADAYKTGHITVEFAPDFSHMKELP-PVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKD--- 472
            .|||..|:.::||:..   :.:...| ...:.:.::..:||.|.|.....:.|....|.|..
Mouse   772 VGADVSKSMYLTVKIP---AMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833

  Fly   473 LYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD----FVSEAKP 533
            .|..:.|.||....|.|.:.|..|:....:.|.|.|.:|.....:||.....||    .:.:.|.
Mouse   834 RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKA 898

  Fly   534 SQLTAT-TMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAY-NRSWSP--DSPYIVEGLRPQT 594
            ..:|.. ||.||  |.|     ||..|.::.|.. :..|.:|. .:..||  :|..|:: :.|.:
Mouse   899 RTITLRWTMGFD--GNS-----PITGYDIECKNK-SDSWDSAQRTKDVSPQLNSATIID-IHPSS 954

  Fly   595 EYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVP 659
            .||.|..|:|::|... ..|:...|...:||:      .|.|....||.    .|....:.|..|
Mouse   955 TYSIRMYAKNRIGKSE-PSNEITITADEAAPD------GPPQEVHLEPT----SSQSIRVTWKAP 1008

  Fly   660 ---ADNGEPIDRYQIKYCPGVKISGTWTELENSCN---TVEVMETTS----FEMTQLVGNTYYRI 714
               ..|| .|..|||.|          .|.....|   .:..::||.    :.:..|...|.|.:
Mouse  1009 KKHLQNG-IIRGYQIGY----------REYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGL 1062

  Fly   715 ELKAHNAIGYSSPASIIMKTT---------RGIDVIQVAERQV-FSSAAIVGIAIGGVL 763
            .::|.|..|....:..|:.||         ..:..|..:...: .|.:.:...|:.|:|
Mouse  1063 VVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGIL 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	24/87 (28%)
		IG_like	144..226	CDD:214653	25/86 (29%)
		IGc2	152..209	CDD:197706	20/58 (34%)
		I-set	230..319	CDD:254352	25/98 (26%)
		IGc2	243..309	CDD:197706	19/66 (29%)
		IG_like	330..424	CDD:214653	24/100 (24%)
		IGc2	339..412	CDD:197706	18/79 (23%)
		Ig	447..518	CDD:143165	19/73 (26%)
		fn3	534..611	CDD:278470	24/80 (30%)
		FN3	640..735	CDD:238020	23/104 (22%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822	23/73 (32%)
		IGc2	518..575	CDD:197706	18/56 (32%)
		Ig	596..686	CDD:386229	28/103 (27%)
		Ig_DSCAM	707..784	CDD:143211	22/91 (24%)
		Ig	802..889	CDD:386229	23/86 (27%)
		FN3	885..978	CDD:238020	28/102 (27%)
		FN3	986..1083	CDD:238020	25/111 (23%)
		FN3	1091..1184	CDD:238020	5/31 (16%)
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900