DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and ncam1b

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_005157462.1	Gene:	ncam1b / 114442	ZFINID:	ZDB-GENE-010822-2	Length:	1055	Species:	Danio rerio

Alignment Length:	843	Identity:	219/843 - (25%)
Similarity:	356/843 - (42%)	Gaps:	126/843 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SLALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQYPTLGQDYVVMCEVK 162
            |..|.|.:..|:..|.|.|.||..:.: .|..|.:|.|..||:||.|..|..|.|.:.:::|:|.
Zfish    76 SSTLTIYNAKVDNAGTYRCVASSGDQD-AEATVNLKIYQKITFTNVPSPQEFTEGDNAIIVCDVI 139

  Fly   163 ADPNPTIDWLRNGDPIRTTNDK--YVVQTNGLLIRNVQESDEGIYTCRAAVIETGELLERTIRVE 225
            :.|.||:.|...|..|:...|.  ..:..|.|.||.::::|||:|||...:...||:..|:|:|.
Zfish   140 SSPPPTVLWKYKGAKIQFDKDVRFKTLSNNHLQIRGIRKTDEGVYTCEGRIKARGEVDFRSIKVV 204

  Fly   226 VFIQP--EIISLPTNLEAVEGKPFAANCTARGKPVPEISWIRDATQLNVATADRFQVNPQTGLVT 288
            |.:.|  .|....||..|..|......|...|.|.|.::|.|:...|.  :.:::..|.....:|
Zfish   205 VNVLPTIRIRQAETNATADMGFSTLLACDPDGFPEPIVTWRRNNAPLE--SGNKYSFNEDGSEMT 267

  Fly   289 ISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRPQIYELYNVTGARTKE-IAITCRAKGRPAPA 352
            :..|::.|.|.|||:|||:||..:|:..|.|.|:|:|..|.:.|.....| :.:||.|.|.|.|.
Zfish   268 VLDVTKLDEGDYTCIAKNKAGESEQELSLKVFVQPKITYLESQTTTEMDEQVTLTCEATGDPTPT 332

  Fly   353 ITFRRWGTQEEYTNGQQDDDPRII----LEPNFDEERGES----------TGTLRISNAERSDDG 403
            ||: .:||: .:|.|:|:...||.    ..|  ::.:|..          ..:|.:...:.:|.|
Zfish   333 ITW-SFGTR-VFTEGEQEQQKRIYQASWTRP--EQHKGPDGEVLVRSDARVSSLTLKYPQYTDAG 393

  Fly   404 LYQCIARNKGADAYKTGHITVEFAPDFSHMKEL--PPVFSWEQRKANLSCLAMGIP-NATIEWHW 465
            .|.|.|||...:..:...:.|.:||     |.|  ..|::||...||:||..:..| :.:|.|..
Zfish   394 QYLCTARNAIGETVQPVSLEVRYAP-----KILGSVAVYTWEGNPANISCEVLAHPSDVSITWLR 453

  Fly   466 NGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPD--FV 528
            :|.::.:...:|:||..|...|.|.|:|.::..:..|.|..:|..||...:..:..|.||.  .:
Zfish   454 DGFQLPNANTSNIKIHNTPSASYLEVNPESQSDFGNYNCTTSNEIGTESREFIMIPADVPSAPSI 518

  Fly   529 SEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYIVEGLRPQ 593
            .|.:|...||..:   ...|.:..|:|:|.|..:::......|...........|...|.||:|:
Zfish   519 GEVQPYSSTAQVL---FEEPESTGGVPVLKYRAEWRAVGRGKWVQRVYEVKDGLSSVTVTGLKPE 580

  Fly   594 TEYSFRFAARNQVGLGNWGVNQQQSTPR--------------RSAPEEPKPLHNPVQHDKEEPVV 644
            |:|..:.:|.|..|.|:...:....|..              .....||.|           |::
Zfish   581 TDYEVKMSAINGKGEGDSSPSMVFKTEHVRYSYTNGIFHFHTEDTEGEPSP-----------PIL 634

  Fly   645 ---VSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQL 706
               :.|..:..:::|....|.|.||..|.::|  ..:....|..        |:...:..|...|
Zfish   635 EGTLQPKGNSLKVKWIKQDDGGSPITHYLVRY--KAREDSEWKP--------EIRLPSGSEYVML 689

  Fly   707 VG---NTYYRIELKAHNAIGYSSPASIIMKT----TRGIDVIQVAERQVFSSAAIVGIAIGGVLL 764
            :|   :|.|.:.:.|.|..|.|.|.::..:|    |...|.::  :....::..||||.|...:|
Zfish   690 IGLDWDTEYDVFVVAENQQGKSKPGTLTFRTSSEPTATTDSME--DGPGLNTGVIVGILILVCVL 752

  Fly   765 LLFVVDLLCCITVHMGVMATMCRKAKRSPSEIDDEAKLGSLYGWRFPLPYCSGQLVKEP------ 823
            ||.:||..||.....|::..:|.|..:|....|.|....:..          ..:.|||
Zfish   753 LLLIVDATCCFLNKCGILMCICGKPGQSTKGKDIETGKAAFV----------QDVSKEPIVEVRT 807

  Fly   824 ---------------PPSPLPLPPPVKLGGS-------PMSTPLDEKEPLRTPTGSIKQNSTI 864
                           |....||..|.::..:       |:|.|.:  ....|.|..:.|:|.:
Zfish   808 EEEATANHDAEGHLEPNETTPLTEPEQVTETAAAVVDLPLSVPTN--SDTITDTFDLSQSSPV 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	11/34 (32%)
		IG_like	144..226	CDD:214653	28/83 (34%)
		IGc2	152..209	CDD:197706	20/58 (34%)
		I-set	230..319	CDD:254352	28/90 (31%)
		IGc2	243..309	CDD:197706	19/65 (29%)
		IG_like	330..424	CDD:214653	27/108 (25%)
		IGc2	339..412	CDD:197706	24/86 (28%)
		Ig	447..518	CDD:143165	21/71 (30%)
		fn3	534..611	CDD:278470	19/76 (25%)
		FN3	640..735	CDD:238020	22/104 (21%)
ncam1b	XP_005157462.1	Ig	20..112	CDD:299845	12/36 (33%)
		I-set	21..111	CDD:254352	11/35 (31%)
		IG_like	121..205	CDD:214653	28/83 (34%)
		IGc2	128..189	CDD:197706	20/60 (33%)
		Ig	208..301	CDD:299845	29/94 (31%)
		I-set	212..298	CDD:254352	27/87 (31%)
		I-set	298..414	CDD:254352	32/119 (27%)
		Ig	300..414	CDD:299845	31/117 (26%)
		IG_like	426..505	CDD:214653	24/78 (31%)
		Ig	434..505	CDD:143165	21/70 (30%)
		FN3	513..606	CDD:238020	22/95 (23%)
		FN3	629..720	CDD:238020	23/111 (21%)
		Chorion_3	<815..1019	CDD:253174	11/56 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	273	1.000	Inparanoid score	I2951
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm25496
orthoMCL	1	0.900	-	-		OOG6_103800
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.830