DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fas2 and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	767	Identity:	156/767 - (20%)
Similarity:	262/767 - (34%)	Gaps:	234/767 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 WTNAPENQYPTLGQDYVVMCEVKADPNPT--IDWLRNGDPIRTTND-----KY-------VVQTN 190
            ::..|.:|...:|:..|:.|.|.   |.|  :.|.::|..:....|     :|       |.|.|
Zfish    27 FSQEPADQSVVIGERVVLSCVVF---NYTGIVQWTKDGLALGIGEDLRAWPRYRVLRIMDVGQYN 88

  Fly   191 GLLIRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPE--IISLPTNLEAVEGKPFAANCTA 253
             |.|.:...:|:.:|.|:|.   ...|..|..::.|.|.|:  :|.....:....|..|...|.:
Zfish    89 -LEITSADLTDDSLYECQAT---EAALRSRRAKLTVLIPPDGPVIEGSPEILLTAGTSFNLTCVS 149

  Fly   254 RG-KPVPEISWIRDATQLNVA------TADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVV 311
            || ||:..|.|.:|...:..|      .:||.:|..:: .:.|..:..|....:||:|.|.|..:
Zfish   150 RGAKPMSTIEWYKDGIIVEGAHTSTEVLSDRKRVTTKS-FLEIQPMDTDTGRNFTCVASNLAAPL 213

  Fly   312 DQKT--KLNVLVRPQI---YELYNV-TGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQD 370
            .:::  .||:...|.:   .|..:| .|.|.|   .||:|...| |.:.: ||.......:|.:
Zfish   214 GKRSTVTLNIHHPPTVILSIEPRSVLEGERVK---FTCQATANP-PIMGY-RWAKGGVILDGAR- 272

  Fly   371 DDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKE 435
                   |..|:.....|..|..:|           |:..|.......:..:.|.|.|..  :.|
Zfish   273 -------ESVFETTADHSFFTEPVS-----------CLVFNAVGSTNVSILVDVHFGPIL--VVE 317

  Fly   436 LPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYS 500
            ..||.........|:|...|.|..|:.|...|..:. |.::|          .|.:..|::....
Zfish   318 PRPVTVDVDSDVTLNCKWSGNPPLTLTWTKKGSSMV-LSNSN----------QLFLKSVSQADAG 371

  Fly   501 GYKCIATNIHGTAEHDMQLKEARVPDF-VSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYK 564
            .|.|                :|.||.. |.|        |.:|..:.||      ||::
Zfish   372 QYVC----------------KAIVPRIGVGE--------TEVTLTVNGP------PIIS------ 400

  Fly   565 EALNPDWSTAYNRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPK 629
                           |....|.|.|.:.:.:...                  .|||   .|::
Zfish   401 ---------------SEPIQYAVRGEKGEIKCYI------------------ASTP---PPDK-- 427

  Fly   630 PLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPIDRYQIKY----CPGVKISGTWTELENSC 690
                          :|..:.::.   |  ..:.|..::||.::.    ..|..:..|.| :.|
Zfish   428 --------------IVWAWKENV---W--EKERGTLLERYTVEQSRPATQGGAVLSTLT-INN-- 470

  Fly   691 NTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTRGIDVIQVAERQVFSSAAIV 755
                ||| ..|:      :||   ...|.||.|   |.::|:.    ::...:|...:.....|.
Zfish   471 ----VME-ADFQ------STY---NCTAWNAFG---PGTMIIT----LEETDIASEDIVPVGVIA 514

  Fly   756 GIAIGGVLLLLFVVDLLCCITVHMGVMATMCRKAKR---------------SPSEIDDEAKLGSL 805
            |.::|..:|||.::..|.......       ||:.|               ..:.:::||...|
Zfish   515 GGSVGSSILLLLLLFALIFYLYRQ-------RKSSRRGVTLKPDIKVETVNKETNLEEEAASAS- 571

  Fly   806 YGWRFPLPYCSGQLVKEPPPSPLPLPPPVKLGGS--PMSTPLDEKEPLRTPT 855
                     .:.::||    :.....|.|.|..|  |....:|.|:.|:|.|
Zfish   572 ---------TATRMVK----AMYSFLPSVSLSPSTQPFKDDMDLKQDLQTET 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653
		IG_like	144..226	CDD:214653	23/95 (24%)
		IGc2	152..209	CDD:197706	18/70 (26%)
		I-set	230..319	CDD:254352	24/99 (24%)
		IGc2	243..309	CDD:197706	20/72 (28%)
		IG_like	330..424	CDD:214653	19/94 (20%)
		IGc2	339..412	CDD:197706	14/72 (19%)
		Ig	447..518	CDD:143165	13/70 (19%)
		fn3	534..611	CDD:278470	10/76 (13%)
		FN3	640..735	CDD:238020	21/98 (21%)
kirrel1b	XP_017212964.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900