DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and ncam2

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_012811963.1	Gene:	ncam2 / 100151722	XenbaseID:	XB-GENE-1217730	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	886	Identity:	226/886 - (25%)
Similarity:	371/886 - (41%)	Gaps:	140/886 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LALLLCS-CSLIELTRAQSPILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQWKDNRNNT 76
            |.||:.| .:|:::|.:.|       |.|:.   ||:....|| ..:.|..   ::.|.:
Frog    39 LGLLVSSGQALMQVTISLS-------KVEIS---VGQSKYFTC-TVIGEAD---NIDWFN----- 84

  Fly    77 ILPKPNGRNQPPMYTETLPGESLA---------LMITSLSVEMGGKYYCTASYANTEILEKGVTI 132
                |.|.       :.:.|:.:.         |.|...:|:..|.|.|.|:.:.....|..|.:
Frog    85 ----PQGE-------KIISGQRVVVQREGIRSWLTIYKANVDDAGIYRCQATDSKGHAQEATVVL 138

  Fly   133 KTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNGDPIRTTNDK--YVVQTNGLLIR 195
            :.|..:|:.:.|..|....|::..|:|.|.:.|.|.:.||.|.:.:...:|:  .::..|.|.|:
Frog   139 EIYQKLTFEDVPSPQEFKRGENAEVLCLVSSSPAPMVRWLNNREDVTDIDDRRFAMLPNNNLQIK 203

  Fly   196 NVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIISLPTNLEAVEGK--PFAANCTARGKPV 258
            |:.:.|||||.|...|...||:..|.|.|.|.:.|||::...:..|...:  .....|.|.|.|.
Frog   204 NISKRDEGIYRCEGRVEVRGEIDFRDISVIVNVPPEILAQQRSFNATADRLEDITLFCRATGSPK 268

  Fly   259 PEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNVLVRP 323
            |.|:|.|:...  |...:::.:......:|:.::...|.|.|.|.|.|:||..::::.|.|.|:|
Frog   269 PYITWHRNGKL--VEENEKYDLREDNTELTVKNIISTDSGLYVCRATNKAGFTEKQSFLQVFVQP 331

  Fly   324 QIYELYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGES 388
            .|.:|.|.|......:.:||.|:|.|.|.||::|......:.:|.:..|.||           ||
Frog   332 HIVQLQNETTIEHGHVTLTCEAEGEPIPEITWKRSSDGMIFYDGDKSQDGRI-----------ES 385

  Fly   389 TG-----TLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRKAN 448
            ||     :|.|.:...||.|.|.|.|.::.....|:.::.:|:||.|...:.:  .:|||....|
Frog   386 TGHHGKSSLHIKSVMLSDAGRYDCEAASRIGGHQKSMYLNIEYAPKFISNQTI--YYSWENNPIN 448

  Fly   449 LSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHGTA 513
            :||.....|.::|.|..:...:.....||:|....|.|..|.:.|::...:..|.|.|.|..|:.
Frog   449 ISCDVTSNPPSSIYWSRDKLLLPARNITNIKTYRDGKRILLEITPLSDNDFGRYNCTAINSIGSR 513

  Fly   514 EHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPSTELGLPILAYSVQYKEALNPDWSTAYNRS 578
            ..:..|..|.||......:..:|:.|........|.:..|:||..|.:.:||..:..|...  ||
Frog   514 IQEYILTLADVPSSPYGLRVIELSQTYAKVFFNKPDSHGGVPIHHYQMDFKEVSSEIWKVV--RS 576

  Fly   579 WSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQ-QQSTPRRSAPEEPKP--LHNPVQHDKE 640
            ....:..::..|...|.|..:.||.|..|.|.:...: .|:.|.|    ||.|  :|......|.
Frog   577 HGTQTIIVLGNLDANTTYEVKVAAVNGKGKGEYSKTEIFQTLPVR----EPSPPSIHGQPGGGKS 637

  Fly   641 EPVVVSPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQ 705
                       |:|......|.|.||..|.:||....| ...|.|.:...|...::      :..
Frog   638 -----------FKLSITKQDDGGAPILNYVVKYRSKDK-EDQWLEKKFLGNKDYII------LDH 684

  Fly   706 LVGNTYYRIELKAHNAIGYSSPA--SIIMKTTRGIDVIQVAERQVFSS---AAIVGIAIGGVLLL 765
            |..|..|.:.:.|.|.:|:|.|.  ..:|.....|    :|: .:||.   .|::|:|:..:||:
Frog   685 LQWNVGYEVHIIATNRLGHSEPTVFEFLMPPKPNI----IAD-TLFSGLGVGAVIGLAVAALLLV 744

  Fly   766 LFVVDLLCCITVHMGVMATMCRK--AKRSPS-----EIDDEAKLGSLYGWRFPLPYCSGQLVKEP 823
            |.|.|:.|......|::..:.|:  .|:|.|     |: :|.|...|               |:.
Frog   745 LVVTDVSCFFIRQCGLLMCITRRICGKKSGSSGKSKEL-EEGKAAYL---------------KDG 793

  Fly   824 PPSPLPLPPPVKL----------GGSPMSTPLDEKEPLRTP 854
            ...|:     |::          .|||::.| :|..||..|
Frog   794 SKEPI-----VEMRTEDERVTNHDGSPVNEP-NETTPLTEP 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	19/102 (19%)
		IG_like	144..226	CDD:214653	28/83 (34%)
		IGc2	152..209	CDD:197706	20/58 (34%)
		I-set	230..319	CDD:254352	23/90 (26%)
		IGc2	243..309	CDD:197706	16/67 (24%)
		IG_like	330..424	CDD:214653	28/98 (29%)
		IGc2	339..412	CDD:197706	25/77 (32%)
		Ig	447..518	CDD:143165	18/70 (26%)
		fn3	534..611	CDD:278470	20/76 (26%)
		FN3	640..735	CDD:238020	22/96 (23%)
ncam2	XP_012811963.1	Ig	50..141	CDD:386229	22/120 (18%)
		IG_like	150..234	CDD:214653	28/83 (34%)
		Ig	237..330	CDD:386229	24/94 (26%)
		Ig	329..426	CDD:386229	32/107 (30%)
		IG_like	442..520	CDD:214653	20/77 (26%)
		FN3	525..617	CDD:238020	21/93 (23%)
		fn3	623..706	CDD:365830	24/100 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3235
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm48806
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.980