DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fas2 and ncam1

DIOPT Version :9

Sequence 1:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster
Sequence 2:	XP_017951446.2	Gene:	ncam1 / 100038291	XenbaseID:	XB-GENE-923171	Length:	1119	Species:	Xenopus tropicalis

Alignment Length:	838	Identity:	224/838 - (26%)
Similarity:	355/838 - (42%)	Gaps:	103/838 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ADLQWKDNRNNTILPKPNGRNQPPMYTETLPGESLALMITSLSVEMGGKYYCTASYANTEILEKG 129
            :|:.|.......:|      ||..:......|.:..|.|.::|.:..|.|.|.|| :.||...:|
Frog    71 SDISWYSPAGEKLL------NQQQISVVKNDGYTSTLTIYNVSSQDAGIYKCVAS-SETEGESEG 128

  Fly   130 -VTIKTYVAITWTNAPENQYPTLGQDYVVMCEVKADPNPTIDWLRNG-DPIRTTNDKYVVQTNGL 192
             |.:|.|..:|:.|||..|....|:|.|::|:|.:.....|.|...| |.|...:.::||.:|..
Frog   129 TVNLKIYQKLTFKNAPTPQEFIEGEDAVIICDVSSSIPSIITWRHRGKDVILKKDVRFVVLSNNY 193

  Fly   193 L-IRNVQESDEGIYTCRAAVIETGELLERTIRVEVFIQPEIIS--LPTNLEAVEGKPFAANCTAR 254
            | ||.|:::|||.|.|...::..||:..:.|.|.|.:.|.:.:  :..|..|...:....:|.|.
Frog   194 LQIRGVKKTDEGTYRCEGRILARGEINYKDIHVIVNVPPTVQARQIRVNATANMDESVVLSCDAD 258

  Fly   255 GKPVPEISWIRDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTKLNV 319
            |.|.|||||::....:... .::...|.....:||..|.:||...|:|:|.|:||..:....|.|
Frog   259 GFPDPEISWLKKGEPIEDG-EEKISFNEDKSEMTIYRVGKDDEAEYSCIANNKAGEAEAIILLKV 322

  Fly   320 LVRPQIYELYNVTGARTKEIAITCRAKGRPAPAITFR---RWGTQEEYTNGQQDDDPRIILEPNF 381
            ..:|:|..:.|.|.....||.:||.|.|.|.|:|::|   |..:.||.|.     |..|:::.:.
Frog   323 YAKPKITYVENKTAVELDEITLTCEASGDPIPSISWRTATRNISSEEKTL-----DGHIVVKEHI 382

  Fly   382 DEERGESTGTLRISNAERSDDGLYQCIARNKGADAYKTGHITVEFAPDFSHMKELPPVFSWEQRK 446
                  ....|.:.:.:.:|.|.|.|||.|...:..:..:..|::||   .:|....|::||...
Frog   383 ------RMSALTLKDIQYTDAGEYICIASNAIGEDMRAMYFEVQYAP---KIKGPVVVYTWEGNP 438

  Fly   447 ANLSCLAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTGPRSDLIVHPVTRQYYSGYKCIATNIHG 511
            .|::|..:..|:|.:.|..:|:.:.....:|:||......|.|.|:|.:...:..|.|.|.|..|
Frog   439 VNITCEVLAYPSAVVSWFRDGQLLPSSNFSNIKIYSGPSSSSLEVNPDSENDFGNYNCTAVNSIG 503

  Fly   512 TAEHDMQLKEARVPDFVSEAKPSQLTATTMT-FDIRGPSTELGLPILAYSVQYKEALNPDWSTAY 575
            ....:..|.:|..|...:..:....::|.|. ||  .|....|:|||.|..::|......|...|
Frog   504 HESSEFILVQADTPSSPAILRVEPYSSTVMVIFD--EPDATGGVPILKYKAEWKVIGQEKWHAKY 566

  Fly   576 --NRSWSPDSPYIVEGLRPQTEYSFRFAARNQVGLGNWGVNQQQSTPRRSAPEEPKPLHNPVQHD 638
              .:..|.:|...|.||:|:|.|..:.:|.|..|||:       |||.:....:|..:..| |.:
Frog   567 YDAKEVSAESIITVTGLKPETSYLVKLSAVNGKGLGD-------STPSQEFTTQPVNIAKP-QGE 623

  Fly   639 KEEPVVV---SPYSDHFELRWGVPADNGEPIDRYQIKYCPGVKISGTW-TELENSCNTVEVMETT 699
            ...|.:|   :...::.::......|.|.||..|.:.|  ....:..| .|:....::..||
Frog   624 PSAPKLVWHLNEDGNNVKVEIIKQDDGGSPIRHYLVNY--RALNAADWKPEMRVPSSSHHVM--- 683

  Fly   700 SFEMTQLVGNTYYRIELKAHNAIGYSSPASIIMKTTR--GIDVIQVAERQVFSSAAIVGIAIGGV 762
               :..|..|..|.:.:.|.|..|.|.||.:..:||.  .......:......:.|||||.|...
Frog   684 ---LKALEWNVEYEVIVVAENQQGKSKPARLSFRTTAKPTATTATTSASAGLGTGAIVGILIVIF 745

  Fly   763 LLLLFVVDLLC----------CITVHMGVMATMCRKAKRSPSEID----------DEAKLGSLYG 807
            :|||.|||:.|          ||.|:      .|.||.......|          ||:|
Frog   746 VLLLVVVDVTCFFLNKCGLLMCIAVN------FCGKAGPGAKGKDIEEGKAAFSKDESK------ 798

  Fly   808 WRFPLPYCSGQLVKEPPPSPLPLPPPVKLGGSPMSTPLDEKEPLRTPTGSIKQNSTIE 865
                .|....:..:|..|:.         .||....| :|..||..|.......:|:|
Frog   799 ----EPIVEVRTEEERTPNH---------DGSNQIEP-NETTPLTEPEHPADTTATVE 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	18/68 (26%)
		IG_like	144..226	CDD:214653	28/83 (34%)
		IGc2	152..209	CDD:197706	22/58 (38%)
		I-set	230..319	CDD:254352	25/90 (28%)
		IGc2	243..309	CDD:197706	19/65 (29%)
		IG_like	330..424	CDD:214653	26/96 (27%)
		IGc2	339..412	CDD:197706	22/75 (29%)
		Ig	447..518	CDD:143165	18/70 (26%)
		fn3	534..611	CDD:278470	26/79 (33%)
		FN3	640..735	CDD:238020	21/98 (21%)
ncam1	XP_017951446.2	Ig	43..136	CDD:416386	19/71 (27%)
		Ig strand A	43..48	CDD:409353
		Ig strand A'	51..55	CDD:409353
		Ig strand B	57..67	CDD:409353
		Ig strand C	71..77	CDD:409353	2/5 (40%)
		Ig strand C'	80..82	CDD:409353	0/1 (0%)
		Ig strand D	89..95	CDD:409353	0/5 (0%)
		Ig strand E	97..105	CDD:409353	2/7 (29%)
		Ig strand F	112..120	CDD:409353	5/8 (63%)
		Ig strand G	124..135	CDD:409353	3/10 (30%)
		IG	144..210	CDD:214652	23/65 (35%)
		IgI_3_NCAM-1	231..325	CDD:143207	26/94 (28%)
		Ig strand B	251..255	CDD:143207	0/3 (0%)
		Ig strand C	264..268	CDD:143207	3/3 (100%)
		Ig strand E	288..292	CDD:143207	0/3 (0%)
		Ig strand F	302..307	CDD:143207	2/4 (50%)
		Ig strand G	315..318	CDD:143207	0/2 (0%)
		Ig	324..419	CDD:416386	28/105 (27%)
		Ig strand A	324..329	CDD:409353	1/4 (25%)
		Ig strand A'	333..337	CDD:409353	2/3 (67%)
		Ig strand B	341..349	CDD:409353	4/7 (57%)
		Ig strand C	355..361	CDD:409353	2/5 (40%)
		Ig strand C'	364..367	CDD:409353	0/2 (0%)
		Ig strand D	375..381	CDD:409353	1/5 (20%)
		Ig strand E	384..390	CDD:409353	1/5 (20%)
		Ig strand F	398..406	CDD:409353	5/7 (71%)
		Ig strand G	409..419	CDD:409353	0/9 (0%)
		Ig_3	423..500	CDD:404760	21/79 (27%)
		Ig strand B	439..443	CDD:409353	1/3 (33%)
		Ig strand C	452..456	CDD:409353	0/3 (0%)
		Ig strand E	479..483	CDD:409353	2/3 (67%)
		Ig strand F	493..498	CDD:409353	2/4 (50%)
		FN3	517..612	CDD:238020	30/103 (29%)
		FN3	624..709	CDD:238020	19/92 (21%)
		Herpes_BLLF1	<776..>1116	CDD:282904	17/87 (20%)
		PRK07994	<918..1075	CDD:236138
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40754
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3235
OMA	1	1.010	-	-		QHG48678
OrthoDB	1	1.010	-	-		D129648at2759
OrthoFinder	1	1.000	-	-		FOG0002001
OrthoInspector	1	1.000	-	-		otm48806
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.980