DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and SAS2

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_013846.1	Gene:	SAS2 / 855157	SGDID:	S000004734	Length:	338	Species:	Saccharomyces cerevisiae

Alignment Length:	334	Identity:	100/334 - (29%)
Similarity:	161/334 - (48%)	Gaps:	49/334 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 GSQDGKTPTPRQSGSMVTHQDDV---VTRMKNVEMIELG-RHRIKPW-----YFSPYPQEL-CQ- 284
            |.::|.....:.|..:...|.::   :...:|:..|:.| ..:...|     ||.|..:.| |.
Yeast    18 GKKNGGKGKNKPSAKIKKTQKEMLYGILNERNIRQIQFGLNKKFSTWYGSAVYFDPETKRLGCSE 82

  Fly   285 --------------MPCIYICEFCLKYRKSRKCLERHLSKCNLRH-PPGNEIYRKHTISFFEIDG 334
                          :..:::||:|.||...:.....|::.|..:: .||...|:....:...:.|
Yeast    83 TKGQLSSVSNSQYWLDTLFVCEYCFKYTDDQTRFVGHVASCPFQYRVPGKIKYKSPEYTIRRVKG 147

  Fly   335 RKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACIL 399
            .|.:::.|.|||..||:||:|::|:..|.:.||::.|..|.  ..:|:|||:..|.:..|:||||
Yeast   148 SKYQLFCQCLCLFTKLYLDNKSMYFKVDHYEFYIVYETGST--KPMGFFSKDLVSYQQNNLACIL 210

  Fly   400 TMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGE 464
            ..|||||:|.|.|||||||:||:.||....||.|||..||:.|..||:| ||...:.:......:
Yeast   211 IFPPYQRRGLGLLLIEFSYKLSQLEGVISGPEVPLSPFGLIGYLKYWSQ-ILCWHLIEGDLAHYD 274

  Fly   465 KPTITINDICECTSIKKEDVISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRKIRIDSKCL 529
            |  :|:.|:...|.::..|||.||::||.|......|:..:|..:                  .|
Yeast   275 K--VTLEDLSIVTGMRVNDVILTLKHLNCIGENNQIYLQSLNSWL------------------KL 319

  Fly   530 HWTPKDWSK 538
            |.|.::|.|
Yeast   320 HGTKRNWFK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553
		Drf_FH1	84..>157	CDD:283903
		PHA01732	139..>196	CDD:222828
		NAT_SF	254..533	CDD:302625	93/301 (31%)
		MOZ_SAS	316..500	CDD:280097	73/183 (40%)
SAS2	NP_013846.1	SAS2	<31..338	CDD:227360	97/321 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870