DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and HAM1

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_201266.1	Gene:	HAM1 / 836582	AraportID:	AT5G64610	Length:	445	Species:	Arabidopsis thaliana

Alignment Length:	504	Identity:	187/504 - (37%)
Similarity:	260/504 - (51%)	Gaps:	142/504 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WPLAEIVSIKELDGRR---------QFYVHYVDFNKRLDEWVNEEDLYTRKVQFPRRDGSQTGTS 94
            |...:...:|.::.|:         ::||||.:||:|||||:..|.|....|:
plant    70 WRDGKYHPVKVIERRKNYNGGHNDYEYYVHYTEFNRRLDEWIKLEQLDLDSVE------------ 122

  Fly    95 TGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSVPPPAGIPNSVAPPGTPSSGGE 159

plant   123 ----------------------------------------------------------------- 122

  Fly   160 LVNGNNLAAALQKRINRKRKNHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGA 224
                    .||.:::..|             :||.:...|......:|      ||.|...:..|
plant   123 --------CALDEKVEDK-------------VTSLKMTRHQKRKIDET------HVEGHEELDAA 160

  Fly   225 ANDDGDGSQDGKTPTPRQSGSMVTHQDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIY 289
                                |:..|::  .|::||:..||||::.|:.|||||:|.|......::
plant   161 --------------------SLREHEE--FTKVKNIATIELGKYEIETWYFSPFPPEYNDCVKLF 203

  Fly   290 ICEFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDH 354
            .|||||.:.|.::.|:||:.||:|:||||:||||..|:|.||:||:||||||||||.||||||||
plant   204 FCEFCLSFMKRKEQLQRHMRKCDLKHPPGDEIYRSSTLSMFEVDGKKNKVYAQNLCYLAKLFLDH 268

  Fly   355 KTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYE 419
            ||||||.|.||||::.|.|.||.|:||||||||.|.|.||:|||||:||||||||||.||.||||
plant   269 KTLYYDVDLFLFYILCECDDRGCHMVGYFSKEKHSEEAYNLACILTLPPYQRKGYGKFLIAFSYE 333

  Fly   420 LSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDV 484
            |||.|||.|:||:|||||||:|||.||.:.:|:|.       ...|..|:|.::.:.|:||.||:
plant   334 LSKKEGKVGTPERPLSDLGLVSYRGYWTRILLDIL-------KKHKGNISIKELSDMTAIKAEDI 391

  Fly   485 ISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRKIRIDSKCLHWTP 533
            :||||:|.||.|.|||:::|.:..::::|.:|..:..:.:|...:.|||
plant   392 LSTLQSLELIQYRKGQHVICADPKVLDRHLKAAGRGGLDVDVSKMIWTP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	16/47 (34%)
		Drf_FH1	84..>157	CDD:283903	0/72 (0%)
		PHA01732	139..>196	CDD:222828	5/56 (9%)
		NAT_SF	254..533	CDD:302625	155/278 (56%)
		MOZ_SAS	316..500	CDD:280097	120/183 (66%)
HAM1	NP_201266.1	PLN00104	1..445	CDD:215056	187/504 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	255	1.000	Domainoid score	I497
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I520
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X828
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830