DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and KAT6A

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_011542958.1	Gene:	KAT6A / 7994	HGNCID:	13013	Length:	2048	Species:	Homo sapiens

Alignment Length:	416	Identity:	175/416 - (42%)
Similarity:	233/416 - (56%)	Gaps:	46/416 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 TPSSGGELVNGNNLAAALQKRINRKRKNHGGSA---------------------HGHHSLTSQQQ 196
            |||..|....|..:..:.|.|| |||.|...|.                     .|...:.:::.
Human   418 TPSPDGRKARGEVVDYSEQYRI-RKRGNRKSSTSDWPTDNQDGWDGKQENEERLFGSQEIMTEKD 481

  Fly   197 QSHPHPTTPQTPTATPVHVTGDGL--------ISGAANDDGDGSQDGKT----PTPRQSGSMVTH 249
            .........|......|.|....|        .||...:: ..:.||||    ..|:|... ||.
Human   482 MELFRDIQEQALQTCAVVVMCKQLYWNWISTFTSGIRLEE-QRAADGKTLKQQTVPQQKVG-VTG 544

  Fly   250 QDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLR 314
            ..|...|..:|  ||.|::.|..||.||||||..::|.:|:|||||||.|||..|::|:.||...
Human   545 PPDPQVRCPSV--IEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWF 607

  Fly   315 HPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHI 379
            |||.||||||:.||.||:||..:.:|.|||||||||||||||||||.:||||||:|:.|.:|.|:
Human   608 HPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHL 672

  Fly   380 VGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRS 444
            ||||||||...:.|||:||:.:|.|||||||:.||:|||.|||.||:.|||||||||||.|||.:
Human   673 VGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMA 737

  Fly   445 YWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNLINYYKGQYIVCINRVI 509
            ||...|||....||..      .|:|..:.:.|.|..:|:.|||.:|.::::...|:::.....:
Human   738 YWKSVILECLYHQNDK------QISIKKLSKLTGICPQDITSTLHHLRMLDFRSDQFVIIRREKL 796

  Fly   510 IEQH--RRAMDKRKIRIDSKCLHWTP 533
            |:.|  :..::.|.:.:|.:||.|||
Human   797 IQDHMAKLQLNLRPVDVDPECLRWTP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553
		Drf_FH1	84..>157	CDD:283903	3/3 (100%)
		PHA01732	139..>196	CDD:222828	14/63 (22%)
		NAT_SF	254..533	CDD:302625	144/280 (51%)
		MOZ_SAS	316..500	CDD:280097	105/183 (57%)
KAT6A	XP_011542958.1	H15	85..162	CDD:197772
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		NAT_SF	549..823	CDD:302625	146/282 (52%)
		MOZ_SAS	609..787	CDD:280097	105/183 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820