Protein Alignment Tip60 and Kat8

DIOPT Version :9

• Sequence 1: NP_001259234.1
• Gene: Tip60 / 31362
• FlyBaseID: FBgn0026080
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_080646.1
• Gene: Kat8 / 67773
• MGIID: 1915023
• Length: 458
• Species: Mus musculus
• Alignment Length: 516
• Identity: 194/516 - (37%)
• Similarity: 270/516 - (52%)
• Gaps: 140/516 - (27%)

  Fly    27 CRLPVRMHKTDDWPLAEIVS--IKELDGRRQFYVHYVDFNKRLDEWVNEEDL-YTRKVQFPRRDG 88
            ||.|     ...|..||::.  :.:.:||.:||||||.||:||||||::..| .|:.|:...:..
Mouse    63 CRRP-----DSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKN 122

  Fly    89 SQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSVPPPAGIPNSVAPPGT 153
            |:...|.....|:|      .::|
Mouse   123 SEKYLSELAEQPER------KITR----------------------------------------- 140

  Fly   154 PSSGGELVNGNNLAAALQKRINRKRK----NHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVH 214
                                 |:|||    ||           .|:..:...|||
Mouse   141 ---------------------NQKRKHDEINH-----------VQKTYAEMDPTT---------- 163

  Fly   215 VTGDGLISGAANDDGDGSQDGKTPTPRQSGSMVTHQDDVVTRMKNVEMIELGRHRIKPWYFSPYP 279
                                          :.:..:.:.:|::|.|:.|.:|.:.|..|||||:|
Mouse   164 ------------------------------AALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFP 198

  Fly   280 QELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNL 344
            ::..:.|.:::||:||||.|..|....||.:|..|.|||.|||||..||.:|:||:.:|:|.|||
Mouse   199 EDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNL 263

  Fly   345 CLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGY 409
            ||||||||||||||:|.:||:||::||.|.:|.||||||||||||.:..|||||||:|||||:||
Mouse   264 CLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGY 328

  Fly   410 GKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDIC 474
            ||.||.|||||||.|...|||||||||||.|||||||:..:|||.       ...:.|::|.|:.
Mouse   329 GKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEIL-------RDFRGTLSIKDLS 386

  Fly   475 ECTSIKKEDVISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRK--IRIDSKCLHWTP 533
            :.|||.:.|:|||||:||::.|:|||:::|:...::|:|.::...:|  |.:||.||.|.|
Mouse   387 QMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAP 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	23/53 (43%)
		Drf_FH1	84..>157	CDD:283903	5/72 (7%)
		PHA01732	139..>196	CDD:222828	7/60 (12%)
		NAT_SF	254..533	CDD:302625	153/280 (55%)
		MOZ_SAS	316..500	CDD:280097	116/183 (63%)
Kat8	NP_080646.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		PLN00104	21..449	CDD:215056	194/516 (38%)
		Sufficient for interaction with KANSL1. /evidence=ECO:0000250|UniProtKB:Q9H7Z6	174..458		154/281 (55%)
		Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q9H7Z6	317..319		1/1 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250|UniProtKB:Q9H7Z6	324..330		4/5 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R415
SonicParanoid	1	1.000	-	-		X828
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740