DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and kat6b

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_009305666.1	Gene:	kat6b / 568932	ZFINID:	ZDB-GENE-000607-52	Length:	2044	Species:	Danio rerio

Alignment Length:	513	Identity:	185/513 - (36%)
Similarity:	262/513 - (51%)	Gaps:	100/513 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQ------TPTGASGSVPPPAGIPNS 147
            :|:.:.:...:|   ||.:...|.|:....||:..|..:..      |..|.|..    .|:| |
Zfish   493 TQSSSPSSAHSP---HSSSSQSSGPSLSSLPGNSQLKGLFDGLSHIFTTQGQSRQ----KGLP-S 549

  Fly   148 VAPPGTPSSGGELVNGNNLAAALQ-----KRINRKRKNHGGSAHGHHSLTSQQQQSHPH------ 201
            .|||.......::.....::..||     |....|..:...||.|......:..:|..|
Zfish   550 YAPPKRVRRTQDMSTSPKMSLQLQGKKPVKGFCSKLASLASSASGWPPKRGRPFKSALHFKRTPI 614

  Fly   202 ------------PTTPQTPTATPVHVTGDGLISGAANDDGDGSQDGKT-PTPR------------ 241
                        ..:||....||    |.|.::           ||:. |.|.
Zfish   615 LRKHKLLGRFRFKASPQRENITP----GKGRLA-----------DGRVKPDPNHAFNVERCLRRE 664

  Fly   242 -QSGSMVTHQDDV-------------VTRMKN-------VEMIELGRHRIKPWYFSPYPQELCQM 285
             |.|.|....|.|             :|..||       ..:||.|::.|:.||.||||.|..::
Zfish   665 PQEGRMTLVNDHVAEEDLKLFRHVKELTAKKNGGDQGQSPPLIEFGKYEIQTWYSSPYPPEYLRL 729

  Fly   286 PCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKL 350
            |.:|:|||||||.||:..|:||..||...|||.||||||..:|.||:||..:|::.|||||||||
Zfish   730 PKLYLCEFCLKYMKSQDILQRHSKKCGWFHPPANEIYRKDNLSVFEVDGNISKIFCQNLCLLAKL 794

  Fly   351 FLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIE 415
            ||||||||||.:||||||:|:.|.:|.|:||||||||...:.|||:||:.||.:||:|:|:.||:
Zfish   795 FLDHKTLYYDVEPFLFYVLTQNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQFQRQGFGRFLID 859

  Fly   416 FSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIK 480
            |||.||:.||:.|||||||||||.|||.:||...||| ::..:|.     .:::|..:...|.:.
Zfish   860 FSYLLSRLEGQAGSPEKPLSDLGRLSYLAYWKSVILE-YLHNHPD-----KSVSIRGMSRATGMC 918

  Fly   481 KEDVISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRKIR-----IDSKCLHWTP 533
            ..|:.:|||.||:|::..|::::.....:||:|   ||:.:::     :|..||.|||
Zfish   919 PHDIATTLQQLNMIDFQDGRFVIIQRHQLIEEH---MDRLRVKPRLHEVDPDCLSWTP 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553
		Drf_FH1	84..>157	CDD:283903	18/73 (25%)
		PHA01732	139..>196	CDD:222828	13/61 (21%)
		NAT_SF	254..533	CDD:302625	141/290 (49%)
		MOZ_SAS	316..500	CDD:280097	100/183 (55%)
kat6b	XP_009305666.1	H15	113..167	CDD:197772
		PHD_SF	212..270	CDD:304600
		PHD2_KAT6A_6B	271..317	CDD:277002
		NAT_SF	707..973	CDD:302625	138/274 (50%)
		MOZ_SAS	760..937	CDD:280097	100/182 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010