DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and kat5b

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_021331810.1	Gene:	kat5b / 503731	ZFINID:	ZDB-GENE-030131-985	Length:	555	Species:	Danio rerio

Alignment Length:	587	Identity:	314/587 - (53%)
Similarity:	380/587 - (64%)	Gaps:	94/587 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ICESTAALTEGCRLPV---RMHKTDDWPLAEIVSIKELDGRRQFYVHYVDFNKRLDEWVNEEDLY 77
            :.|.|..:.|||||||   .....|:||||||:|:|::.||:.:||||:||||||||||..:.|.
Zfish     1 MAEPTVEIVEGCRLPVLRKNQENEDEWPLAEILSVKDIPGRKLYYVHYIDFNKRLDEWVTPDRLD 65

  Fly    78 TRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGAL------AAIPQ------T 130
            .:|:|||::: ::|.|..|         |.|  |||:||:.....:|      |:.|.      |
Zfish    66 LKKLQFPKKE-AKTPTKNG---------LPG--SRPSSPEREVRKSLDLNVQSASAPSRGKTLPT 118

  Fly   131 PTGASGSVPPPAGIPNSVAPPGTPSSG---------------------------GELVNGNNLAA 168
            |...:.||.....:..:...|..|||.                           ..|........
Zfish   119 PKRKAESVSLATQVTAATPVPSLPSSAEASQASVYPAMRDSSFSIKAREEHEQLTSLTTNGTTRR 183

  Fly   169 ALQKRINRKRKNHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAANDDGDGSQ 233
            .:..:..|||||    ..|...:....|.:.|..:|...|                ..:|...|.
Zfish   184 LIPSQPGRKRKN----CVGTEEIVKVFQNNSPRSSTVYLP----------------PGEDSQDSS 228

  Fly   234 DGKTPTPRQSGSMVTHQ--DDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLK 296
            ||....||.:||:|:.:  ||::|||||::.|||||||:||||||||||||..:|.:|:||||||
Zfish   229 DGIPSAPRMTGSLVSDRSHDDIITRMKNIDCIELGRHRLKPWYFSPYPQELTTLPILYLCEFCLK 293

  Fly   297 YRKSRKCLERHL-----------------SKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNL 344
            |.||.|||:|||                 :|||||||||||||||.|||||||||||||:|:|||
Zfish   294 YLKSLKCLQRHLVRAVLGPDVTHSQHQIKTKCNLRHPPGNEIYRKGTISFFEIDGRKNKMYSQNL 358

  Fly   345 CLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGY 409
            |||||.|||||||||||||||||||||:||:|||||||||||||||||||||||||:|||||:||
Zfish   359 CLLAKCFLDHKTLYYDTDPFLFYVMTEYDSKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGY 423

  Fly   410 GKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDIC 474
            |||||||||||||.|||||:|||||||||||||||||:||||||.::.. |.:||:|.:|||:|.
Zfish   424 GKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMNLK-SENGERPQMTINEIS 487

  Fly   475 ECTSIKKEDVISTLQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRKIRIDSKCLHWTPKDWSKR 539
            |.||:||||||||||.||||||||||||:.::..|:|.|.|||.||.:||||||||:||||||||
Zfish   488 EITSVKKEDVISTLQYLNLINYYKGQYILTLSEDIVEGHERAMHKRHLRIDSKCLHFTPKDWSKR 552

  Fly   540 SK 541
            .|
Zfish   553 GK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	33/57 (58%)
		Drf_FH1	84..>157	CDD:283903	21/84 (25%)
		PHA01732	139..>196	CDD:222828	11/83 (13%)
		NAT_SF	254..533	CDD:302625	223/295 (76%)
		MOZ_SAS	316..500	CDD:280097	156/183 (85%)
kat5b	XP_021331810.1	Tudor-knot	8..66	CDD:314560	33/57 (58%)
kat5b	XP_021331810.1	MOZ_SAS	<243..546	CDD:332306	225/303 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592806
Domainoid	1	1.000	328	1.000	Domainoid score	I1144
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100661
Inparanoid	1	1.050	596	1.000	Inparanoid score	I933
OMA	1	1.010	-	-		QHG53218
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	1	1.000	-	-		FOG0004802
OrthoInspector	1	1.000	-	-		otm24941
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R415
SonicParanoid	1	1.000	-	-		X828
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800