Protein Alignment Tip60 and lsy-12

DIOPT Version :10

• Sequence 1: NP_572151.1
• Gene: Tip60 / 31362
• FlyBaseID: FBgn0026080
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_001263849.1
• Gene: lsy-12 / 3565873
• WormBaseID: WBGene00045419
• Length: 1585
• Species: Caenorhabditis elegans
• Alignment Length: 627
• Identity: 172/627 - (27%)
• Similarity: 254/627 - (40%)
• Gaps: 168/627 - (26%)

  Fly    25 EGC--RLPVRMHKTDD-------WPLAEIVSIKELDGRRQFYVHYVDFNKRLDEWVNEEDLYTRK 80
            |||  .:|:.:...|:       .|..|.|::.|              |....|..::|...|::
 Worm   256 EGCIVEVPIPLIDLDNDAVESVTGPQHENVTVSE--------------NVLSTESTDQEVTETKR 306

  Fly    81 VQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQ-HPGSGALAAIPQTPTGASGSVPPPAGI 144
            :....||          ..|.|......:|.||...| .|.|...:....|......|:     :
 Worm   307 LHDSSRD----------FNPPRIQDTPSTVIRPEGDQKDPMSSTSSKRRNTNNSRCASL-----L 356

  Fly   145 PNSVAPPGTP-------------SSGGELVNGNNLAAALQKRINRKRKNHGGSAHGHHSLTSQQQ 196
            .|   |..||             |...|:::.:....|.:.|..|.|          :|..:|::
 Worm   357 SN---PHSTPVTRLMRGILDSENSDNDEMLSNDQSEIAKRPRTPRPR----------YSPEAQRR 408

  Fly   197 -QSHPHPTTPQTPTATPVHVTGDGLIS------GAANDDGD--------GSQDG------KTPTP 240
             .|.....|..|..:..::|.|....|      |.:..|.|        |:|..      |||:|
 Worm   409 TNSRLSALTIDTNRSNDLNVDGSAPSSSSAASCGLSTPDPDRTSQQRRKGNQSAARSRKIKTPSP 473

  Fly   241 RQSGS----MVTHQDDVVTRMKNV----------------------------------------- 260
            ..|..    .:...||.|..:.|:
 Worm   474 PLSQEDEPMELDSDDDPVNELDNLPIVIDDPSYVLTKEHKEIFEQVKKSVSDRNEFSPAQISEIY 538

  Fly   261 -----------EMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLR 314
                       |.|..|...:|.||.||:|.|...:..::|||||..|.:|.:.::.|..||.||
 Worm   539 RSSKGEQARLPERIHFGAFIMKTWYGSPFPAEFINVKKLFICEFCFFYARSDEIMQNHAKKCMLR 603

  Fly   315 HPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHI 379
            .|||.|||||..||.||:|||..|.|.|.|||::::||:.||::|||:||.||::|..|..|.|.
 Worm   604 APPGLEIYRKGDISVFEVDGRLQKEYCQTLCLVSRMFLESKTVFYDTEPFFFYIVTINDDIGCHF 668

  Fly   380 VGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRS 444
            .|||||||...:..|::||:|:|.||..|.|:.||:.||.||:.|...|.||:|||:||..:|..
 Worm   669 AGYFSKEKYEPDVNNLSCIMTLPCYQEMGLGRFLIDISYALSRKEKWFGGPEQPLSELGRKAYGG 733

  Fly   445 YWAQTIL--------EIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNLI------- 494
            ||..||.        |:.....         |:|..|.:.|.:...|::..:.:|...
 Worm   734 YWRTTIASCLGRLKDELEFGSG---------ISIKMIADDTGVNCHDILEVVCSLGWAKPVDPDE 789

  Fly   495 -NYYKGQYIVCINRV-IIEQHRRAMDKRKIRIDSKCLHWTPK 534
             |:||.::.|..:.| ||.:...|..:.|::.|.:||.|.|:
 Worm   790 KNHYKLEWDVDWDMVSIILRESEASKETKVQYDPECLDWVPR 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_572151.1	CBD_TIP60_like	27..90	CDD:350848	13/71 (18%)
		PLN00104	<255..533	CDD:215056	115/346 (33%)
lsy-12	NP_001263849.1	zf-MYST	547..600	CDD:407644	18/52 (35%)
		MOZ_SAS	605..786	CDD:460362	79/189 (42%)