DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and Kat6a

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001094040.1	Gene:	Kat6a / 306571	RGDID:	1304892	Length:	1998	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	185/510 - (36%)
Similarity:	258/510 - (50%)	Gaps:	105/510 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LYTRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSR-PTSPQH--PGSGALAAIPQTPTGAS-- 135
            |..:..|..||..:..|      .|:.......:||: |.|...  ||.|....|..:...||
  Rat   320 LQKKAAQIKRRYANPIG------RPKNRLKKQSTVSKGPFSKVRTGPGRGRKRKITVSSQSASSS 378

  Fly   136 ----------------GSVP-----PPAGIPNSVAPPGTPSSGGELVNGNNL---AAALQKRINR 176
                            .|.|     ...|:.:.:....|||..|....|..:   ...::|:.||
  Rat   379 EEGYLERIDGLDFCRDSSAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEAVDYSELRIRKKGNR 443

  Fly   177 KRKNHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAANDDGDGSQDGKTPTPR 241
            |                        .:|...||                 |:.||.:..:....|
  Rat   444 K------------------------SSTSHWPT-----------------DNQDGWESKQESEER 467

  Fly   242 QSGS--MVTHQD-----DV---------VT-----RMKNVEMIELGRHRIKPWYFSPYPQELCQM 285
            ..||  ::|.:|     |:         ||     :::...:||.|::.|..||.||||||..::
  Rat   468 LFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRL 532

  Fly   286 PCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKL 350
            |.:|:|||||||.|||..|::|:.||...|||.||||||:.||.||:||..:.:|.|||||||||
  Rat   533 PKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKL 597

  Fly   351 FLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIE 415
            ||||||||||.:||||||:|:.|.:|.|:||||||||...:.|||:||:.:|.|||||||:.||:
  Rat   598 FLDHKTLYYDVEPFLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLID 662

  Fly   416 FSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIK 480
            |||.|||.||:.|||||||||||.|||.:||...|||....||..      .|:|..:.:.|.:.
  Rat   663 FSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDK------QISIKKLSKLTGVC 721

  Fly   481 KEDVISTLQNLNLINYYKGQYIVCINRVIIEQH--RRAMDKRKIRIDSKCLHWTP 533
            .:|:.|||.:|.::::...|:::.....:|:.|  :..::.|.:.:|.:||.|||
  Rat   722 PQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTP 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	1/1 (100%)
		Drf_FH1	84..>157	CDD:283903	20/98 (20%)
		PHA01732	139..>196	CDD:222828	11/64 (17%)
		NAT_SF	254..533	CDD:302625	143/285 (50%)
		MOZ_SAS	316..500	CDD:280097	104/183 (57%)
Kat6a	NP_001094040.1	Required for activation of RUNX1-1. /evidence=ECO:0000250\|UniProtKB:Q92794	1..144
		Required for nuclear localization. /evidence=ECO:0000250	52..166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..93
		H15	85..162	CDD:197772
		Interaction with PML. /evidence=ECO:0000250	144..662		137/388 (35%)
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..662		137/388 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..377		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..464		9/64 (14%)
		Catalytic. /evidence=ECO:0000250	486..776		143/295 (48%)
		PLN00104	<502..776	CDD:215056	141/279 (51%)
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	505..808		143/278 (51%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	643..647		2/3 (67%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	652..658		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..947
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	982..1079
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1175
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1195..1436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1450..1567
		Interaction with PML. /evidence=ECO:0000250	1510..1735
		Interaction with RUNX1-2. /evidence=ECO:0000250	1510..1635
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1630..1702
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1907..1942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920