DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and kat6a

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001116784.4	Gene:	kat6a / 266966	ZFINID:	ZDB-GENE-021022-3	Length:	2246	Species:	Danio rerio

Alignment Length:	477	Identity:	181/477 - (37%)
Similarity:	251/477 - (52%)	Gaps:	81/477 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSV---PPPAGIPN 146
            |..|.....|.|.::|   ||.:.|    :...:||...:....:....|.||:   ....|:.:
Zfish   380 RGAGGVDQCSQGSSSP---HSSSSS----SCEGYPGDDRMLFSLREDDSAHGSLRFNKKTKGLID 437

  Fly   147 SVAPPGTPSSGGELVNGNNLAAALQKRINRKRKNHGGSAH----------------------GHH 189
            :::...|||..|.......:..:.|.|: ||:.|..|. |                      ||.
Zfish   438 ALSKFFTPSPDGRKARAEVVDYSQQYRM-RKKGNRKGE-HDDRTGDNQECSDSWREDEDKLPGHE 500

  Fly   190 SLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAANDDGDGSQDGKTPTPRQSGSMVTHQDDVV 254
            :||.:..:...|   .|......|.|||                   .|.|
Zfish   501 NLTEKDVELFRH---IQEIALQKVGVTG-------------------PPDP-------------- 529

  Fly   255 TRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKCLERHLSKCNLRHPPGN 319
             :|:...:||.|::.|:.||.||||||..::|.:|:|||||:|.|||..|.:|:.|||..|||.|
Zfish   530 -QMRCPSVIEFGKYEIQTWYSSPYPQEYSRLPKLYLCEFCLRYMKSRSILYQHMRKCNWFHPPAN 593

  Fly   320 EIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLFYVMTEFDSRGFHIVGYFS 384
            |||||..:|.||:||..:.:|.|||||||||||||||||||.:||||||:|:.|::|.|:|||||
Zfish   594 EIYRKDDVSVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDNKGCHLVGYFS 658

  Fly   385 KEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKPLSDLGLLSYRSYWAQT 449
            |||...:.|||:||:.:|.|||||||:.||:|||.|||.||:.|||||||||||.|||.:||...
Zfish   659 KEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQPGSPEKPLSDLGRLSYMAYWRSV 723

  Fly   450 ILEIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNLINYYKGQYIVCINR-VIIEQH 513
            :||..   :...|.:   ::|..:.:.|.|..:|:.:||.|||::. .||..::.:.| .::..|
Zfish   724 VLECL---HEIRDRQ---LSIRKLSKVTGICPQDITATLLNLNMLE-QKGDGVIIMRREKLVANH 781

  Fly   514 --RRAMDKRKIRIDSKCLHWTP 533
              |.....|.:.:|..||.|||
Zfish   782 MARLKAKPRLLEVDPDCLRWTP 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553
		Drf_FH1	84..>157	CDD:283903	17/74 (23%)
		PHA01732	139..>196	CDD:222828	16/78 (21%)
		NAT_SF	254..533	CDD:302625	142/281 (51%)
		MOZ_SAS	316..500	CDD:280097	103/183 (56%)
kat6a	NP_001116784.4	H15	122..185	CDD:197772
		PHD1_MOZ_MORF	226..283	CDD:277090
		PHD2_KAT6A_6B	285..331	CDD:277002
		NAT_SF	535..804	CDD:302625	143/276 (52%)
		MOZ_SAS	590..767	CDD:280097	103/183 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820