DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and mst1

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_594630.1	Gene:	mst1 / 2543506	PomBaseID:	SPAC637.12c	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	502	Identity:	204/502 - (40%)
Similarity:	286/502 - (56%)	Gaps:	84/502 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KTDDWPLAEIVSIKELDGRRQFYVHYVDFNKRLDEWVNEEDL-YTRKVQFPRRDGSQTGTSTGVT 98
            |..::..|||:.|::......:||||.|:|||||||:..::: .::.:::|..:
pombe    31 KDGEYRKAEILMIQKRTRGVVYYVHYNDYNKRLDEWITIDNIDLSKGIEYPPPE----------- 84

  Fly    99 TPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSVPPPAGIPNSVAP-PGTPSSGGELVN 162
            .|::.|....|..||.:...         .::.|..|.:.|   ..|::..| |.|||  ||
pombe    85 KPKKAHGKGKSSKRPKAVDR---------RRSITAPSKTEP---STPSTEKPEPSTPS--GE--- 132

  Fly   163 GNNLAAALQKRINRKRKNHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAAND 227
                            .:||.:| |:.||...::...|...
pombe   133 ----------------SDHGSNA-GNESLPLLEEDHKPESL------------------------ 156

  Fly   228 DGDGSQDGKTPTPRQSGSMVTHQDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICE 292
                |::.:....|.|||||.:..: :.|::|:..|.:|.|.|:||||||||:|..::..:|||.
pombe   157 ----SKEQEVERLRFSGSMVQNPHE-IARIRNINKICIGDHEIEPWYFSPYPKEFSEVDIVYICS 216

  Fly   293 FCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTL 357
            ||..|..|.:..:||..||.|:|||||||||...||||||||||.:.:.:|:|||:|||||||.|
pombe   217 FCFCYYGSERQFQRHREKCTLQHPPGNEIYRDDYISFFEIDGRKQRTWCRNICLLSKLFLDHKML 281

  Fly   358 YYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSK 422
            |||.||||||.|...|..|.|:||||||||||:|:||:|||||:|.|||.|||||||:|||||:|
pombe   282 YYDVDPFLFYCMCRRDEYGCHLVGYFSKEKESSENYNLACILTLPQYQRHGYGKLLIQFSYELTK 346

  Fly   423 FEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVIST 487
            .|.|.||||||||||||:|||:|||:.|:.:.:.....|       ||:::...||:...||:.|
pombe   347 REHKHGSPEKPLSDLGLISYRAYWAEQIINLVLGMRTET-------TIDELANKTSMTTNDVLHT 404

  Fly   488 LQNLNLINYYKGQYIVCINRVIIEQHRRAMDKRKIRIDSKCL-HWTP 533
            ||.||::.|||||:|:||:..|.:|:.|..:|::.||:...| .|.|
pombe   405 LQALNMLKYYKGQFIICISDGIEQQYERLKNKKRRRINGDLLADWQP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	17/43 (40%)
		Drf_FH1	84..>157	CDD:283903	15/73 (21%)
		PHA01732	139..>196	CDD:222828	15/57 (26%)
		NAT_SF	254..533	CDD:302625	155/279 (56%)
		MOZ_SAS	316..500	CDD:280097	114/183 (62%)
mst1	NP_594630.1	SAS2	16..447	CDD:227360	201/496 (41%)
		Tudor-knot	21..74	CDD:288553	17/42 (40%)
		NAT_SF	176..451	CDD:302625	155/282 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	243	1.000	Domainoid score	I439
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100661
Inparanoid	1	1.050	358	1.000	Inparanoid score	I467
OMA	1	1.010	-	-		QHG53218
OrthoFinder	1	1.000	-	-		FOG0004802
OrthoInspector	1	1.000	-	-		oto101647
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R415
SonicParanoid	1	1.000	-	-		X828
TreeFam	1	0.960	-	-
	13	12.760