DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tip60 and Kat6a

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001074618.1	Gene:	Kat6a / 244349	MGIID:	2442415	Length:	2003	Species:	Mus musculus

Alignment Length:	497	Identity:	193/497 - (38%)
Similarity:	259/497 - (52%)	Gaps:	78/497 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LYTRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSR-PTSPQH--PGSGALAAIPQTPTGASGS 137
            |..:..|..||..:..|      .|:.......:||: |.|...  ||.|....|..:...||.|
Mouse   320 LQKKAAQIKRRYANPIG------RPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITVSSQSASSS 378

  Fly   138 ------------------VP-----PPAGIPNSVAPPGTPSSGGELVNGNNLAAALQKRINRKRK 179
                              .|     ...|:.:.:....|||..|....|..:..:.|.|| ||:.
Mouse   379 EEGYLERIDGLDFCRDSNAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRI-RKKG 442

  Fly   180 NHGGSAHGHHSLTSQQQQSHPHPTTPQTPTATPVHVTGDGLISGAANDDG-DGSQDGKTPTPR-- 241
            |...|       ||.      .||..|           ||..|...|::. .|||:..|....
Mouse   443 NRKSS-------TSD------WPTDNQ-----------DGWESKQENEERLFGSQEIMTERDMEL 483

  Fly   242 ----QSGSM----VTHQDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYR 298
                |..::    ||...|...|..:|  ||.|::.|..||.||||||..::|.:|:|||||||.
Mouse   484 FRDIQEQALQKVGVTGPPDPQVRCPSV--IEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYM 546

  Fly   299 KSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDP 363
            |||..|::|:.||...|||.||||||:.||.||:||..:.:|.|||||||||||||||||||.:|
Mouse   547 KSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEP 611

  Fly   364 FLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTG 428
            |||||:|:.|.:|.|:||||||||...:.|||:||:.:|.|||||||:.||:|||.|||.||:.|
Mouse   612 FLFYVLTQNDVKGCHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAG 676

  Fly   429 SPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNL 493
            ||||||||||.|||.:||...|||....||..      .|:|..:.:.|.:..:|:.|||.:|.:
Mouse   677 SPEKPLSDLGRLSYMAYWKSVILECLYHQNDK------QISIKKLSKLTGVCPQDITSTLHHLRM 735

  Fly   494 INYYKGQYIVCINRVIIEQH--RRAMDKRKIRIDSKCLHWTP 533
            :::...|:::.....:|:.|  :..::.|.:.:|.:||.|||
Mouse   736 LDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTP 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	1/1 (100%)
		Drf_FH1	84..>157	CDD:283903	20/98 (20%)
		PHA01732	139..>196	CDD:222828	16/61 (26%)
		NAT_SF	254..533	CDD:302625	143/280 (51%)
		MOZ_SAS	316..500	CDD:280097	104/183 (57%)
Kat6a	NP_001074618.1	Required for activation of RUNX1-1. /evidence=ECO:0000250\|UniProtKB:Q92794	1..144
		Required for nuclear localization. /evidence=ECO:0000250	52..166
		H15	85..162	CDD:197772
		Interaction with PML. /evidence=ECO:0000250	144..663		145/375 (39%)
		PHD1_MOZ_MORF	205..262	CDD:277090
		PHD2_KAT6A_6B	264..310	CDD:277002
		Interaction with RUNX1-1. /evidence=ECO:0000250	312..663		145/375 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..377		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..466		12/50 (24%)
		Catalytic. /evidence=ECO:0000250	487..777		147/297 (49%)
		MOZ_SAS	<503..777	CDD:332306	143/281 (51%)
		Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity. /evidence=ECO:0000250	506..809		145/280 (52%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	644..648		2/3 (67%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q92794	653..659		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1438
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1533
		Interaction with PML. /evidence=ECO:0000250	1511..1740
		Interaction with RUNX1-2. /evidence=ECO:0000250	1511..1636
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1546..1568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1631..1707
		Required for activation of RUNX1-2. /evidence=ECO:0000250	1912..1947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D629545at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820