Protein Alignment Tip60 and KAT6B

DIOPT Version :10

• Sequence 1: NP_572151.1
• Gene: Tip60 / 31362
• FlyBaseID: FBgn0026080
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_036462.2
• Gene: KAT6B / 23522
• HGNCID: 17582
• Length: 2073
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 204/625 - (32%)
• Similarity: 291/625 - (46%)
• Gaps: 142/625 - (22%)

  Fly    19 STAALTEGCR--LPVRMHKTDDWPLAEIVSIKE-----LDGRRQFYVHYVDFNKRLDEWVNEEDL 76
            |..|:|:..|  ...::..|..:..|..:.:.:     :||..:|:....|..:...|.::....
Human   397 SRLAVTDPTRPGATTKITTTSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGRRSRGEIIDFSKH 461

  Fly    77 YTRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASGSVPPP 141
            |.     ||:..||..:.|.       |.||...::...|  |.|    ::| .||..||..|..
Human   462 YR-----PRKKVSQKQSCTS-------HVLATGTTQKLKP--PPS----SLP-PPTPISGQSPSS 507

  Fly   142 AGIPNSVAPPGTPSSGGE--------LVNGNNLAA-----------------------ALQKRIN 175
            .....:.:.|...||..:        |...:.|.|                       |..||:.
Human   508 QKSSTATSSPSPQSSSSQCSVPSLSSLTTNSQLKALFDGLSHIYTTQGQSRKKGHPSYAPPKRMR 572

  Fly   176 RKRK----------------------NHG-----GSAHG-------HHSLTSQQQQSH-----PH 201
            ||.:                      :|.     |.|.|       |...|:..::..     .:
Human   573 RKTELSSTAKSKAHFFGKRDIRSRFISHSSSSSWGMARGSIFKAIAHFKRTTFLKKHRMLGRLKY 637

  Fly   202 PTTPQTPTATPVHVTGDG-LISGAANDDGDGSQDGKTPTPRQSG--------SMVTHQD-DVVTR 256
            ..|||..|.:|    |.| |..|....|.|...:.|....::|.        .:||.:| ||..:
Human   638 KVTPQMGTPSP----GKGSLTDGRIKPDQDDDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQ 698

  Fly   257 MKNV------------------EMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSRKC 303
            .:.:                  .:||.|::.|:.||.||||||..::|.:|:|||||||.||:..
Human   699 AQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNI 763

  Fly   304 LERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLFYV 368
            |.||..||...|||.|||||:..:|.||:||..:|:|.|||||||||||||||||||.:||||||
Human   764 LLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYV 828

  Fly   369 MTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPEKP 433
            :|:.|.:|.|:||||||||...:.|||:||:.||.:||:|:|:.||:|||.||:.||:.||||||
Human   829 LTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKP 893

  Fly   434 LSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNLINYYK 498
            |||||.|||.:||...|||.....:      :..|:|..|...|.:...|:.:|||:|::|:...
Human   894 LSDLGRLSYLAYWKSVILEYLYHHH------ERHISIKAISRATGMCPHDIATTLQHLHMIDKRD 952

  Fly   499 GQYIVCINRVIIEQHRRAMDKRKI-----RIDSKCLHWTP 533
            |::::.....:|..|   |:|.|.     .:|...|.|||
Human   953 GRFVIIRREKLILSH---MEKLKTCSRANELDPDSLRWTP 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_572151.1	CBD_TIP60_like	27..90	CDD:350848	11/69 (16%)
		PLN00104	<255..533	CDD:215056	138/300 (46%)
KAT6B	NP_036462.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..97
		H15	113..167	CDD:197772
		PHD1_MOZ_MORF	212..269	CDD:277090
		PHD2_KAT6A_6B	271..317	CDD:277002
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..409		4/11 (36%)
		Negatively regulates HAT activity	361..717		64/342 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..531		23/107 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..583		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..663		10/27 (37%)
		Catalytic	718..1008		140/281 (50%)
		PLN00104	<721..989	CDD:215056	138/276 (50%)
		Interaction with BRPF1. /evidence=ECO:0000269|PubMed:18794358	752..1008		125/247 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1452
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1484..1538
		Interaction with RUNX1 and RUNX2. /evidence=ECO:0000269|PubMed:11965546	1560..2073
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1580..1619