DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tip60 and Kat5

DIOPT Version :9

Sequence 1:	NP_001259234.1	Gene:	Tip60 / 31362	FlyBaseID:	FBgn0026080	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_038948520.1	Gene:	Kat5 / 192218	RGDID:	621061	Length:	555	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	317/565 - (56%)
Similarity:	380/565 - (67%)	Gaps:	76/565 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ICESTAALT------EGCRLPV---RMHKTDDWPLAEIVSIKELDGRRQFYVHYVDFNKRLDEWV 71
            :.:..|||:      |||||||   .....|:||||||:|:|::.||:.|||||:||||||||||
  Rat    27 VADPGAALSPQGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWV 91

  Fly    72 NEEDLYTRKVQFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTSPQHPGSGALAAIPQTPTGASG 136
            ..|.|..:|:|||::: ::|.|..|         |.|  |||.||:.       .:.:|
  Rat    92 THERLDLKKIQFPKKE-AKTPTKNG---------LPG--SRPGSPER-------EVRKT------ 131

  Fly   137 SVPPPAGIPNSVAPPGTPSSGGELVNGNNLAAALQKRINRKRKNH---GGSAHGHHSLTSQQQQS 198
                   :..|:.|....:||..|    .:...:..|.|..::..   ||......|.:|..|.:
  Rat   132 -------LDLSLQPASAQASGKTL----PIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPN 185

  Fly   199 H---------PHPTTPQTPTATPVHV---TGDGLISGAA-------------NDDGDGSQDGKTP 238
            |         ..|.||......|..|   .|....:.||             ::|...|.||...
  Rat   186 HRSTKRKVEVVSPATPVPSETAPASVFPQNGSARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPS 250

  Fly   239 TPRQSGSMVTHQ--DDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYICEFCLKYRKSR 301
            .||.:||:|:.:  ||:||||||:|.|||||||:||||||||||||..:|.:|:|||||||.:|.
  Rat   251 APRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSL 315

  Fly   302 KCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKTLYYDTDPFLF 366
            |||:|||:||:||||||||||||.|||||||||||||.|:||||||||.||||||||||||||||
  Rat   316 KCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLF 380

  Fly   367 YVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELSKFEGKTGSPE 431
            |||||:|.:|||||||||||||||||||||||||:|||||:|||||||||||||||.|||||:||
  Rat   381 YVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPE 445

  Fly   432 KPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVISTLQNLNLINY 496
            |||||||||||||||:||||||.:... |..||:|.||||:|.|.|||||||||||||.||||||
  Rat   446 KPLSDLGLLSYRSYWSQTILEILMGLK-SESGERPQITINEISEITSIKKEDVISTLQYLNLINY 509

  Fly   497 YKGQYIVCINRVIIEQHRRAMDKRKIRIDSKCLHWTPKDWSKRSK 541
            ||||||:.::..|::.|.|||.||.:||||||||:||||||||.|
  Rat   510 YKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_001259234.1	Tudor-knot	23..78	CDD:288553	36/63 (57%)
		Drf_FH1	84..>157	CDD:283903	14/72 (19%)
		PHA01732	139..>196	CDD:222828	11/59 (19%)
		NAT_SF	254..533	CDD:302625	223/278 (80%)
		MOZ_SAS	316..500	CDD:280097	157/183 (86%)
Kat5	XP_038948520.1	CBD_TIP60_like	47..110	CDD:350848	34/63 (54%)
Kat5	XP_038948520.1	PLN00104	<260..546	CDD:215056	225/286 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100661
Inparanoid	1	1.050	589	1.000	Inparanoid score	I959
OMA	1	1.010	-	-		QHG53218
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	1	1.000	-	-		FOG0004802
OrthoInspector	1	1.000	-	-		oto97838
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X828
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980