Protein Alignment Tip60 and KAT7

DIOPT Version :10

• Sequence 1: NP_572151.1
• Gene: Tip60 / 31362
• FlyBaseID: FBgn0026080
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_008998.1
• Gene: KAT7 / 11143
• HGNCID: 17016
• Length: 611
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 198/572 - (34%)
• Similarity: 285/572 - (49%)
• Gaps: 127/572 - (22%)

  Fly    65 KRLDEWVNEEDLY-TRKV-------------QFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTS 115
            :.|..:..||..| ||:|             ::|.|....:|:.|.............:.....|
Human    60 RNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDES 124

  Fly   116 PQHPGSGALAAIPQTPTGASGSVPPPAGI--PN-----SVAPPGTPSSGGELVNGNNLAAALQKR 173
            |           |:||||.:.|......|  ||     |:|...:...     :|::|:...::|
Human   125 P-----------PRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKD-----SGSDLSHRPKRR 173

  Fly   174 -------INRKRKNHGGSAHGH-----------------HSLTS--------------------- 193
                   .|.|....|.::.||                 |:|::
Human   174 RFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSH 238

  Fly   194 QQQQSHPHPTTPQTPTATPVHV----------TGDGLISGAANDDGDGSQD-GKTPTP------- 240
            :|..::.|.|..|.||...:..          ...||.........:..|. |.|..|
Human   239 RQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTS 303

  Fly   241 -------RQSGSMVTH-------QDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYIC 291
                   |::.:..:.       |..:......::.|..||:.:..||.||||:|..::..:|:|
Human   304 EYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMC 368

  Fly   292 EFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKT 356
            ||||||.||:..|.||::||..:||||:|||||.:||.||:||:|||:|.|||||||||||||||
Human   369 EFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKT 433

  Fly   357 LYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELS 421
            ||||.:|||||||||.|:.|.|::|||||||.|..:|||:||||||.|.|:||||:||:|||.||
Human   434 LYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLS 498

  Fly   422 KFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVIS 486
            |.|.|.||||:|||||||:||||||.:.:|...    .:..|::  |:|.:|.:.|::...|::|
Human   499 KVEEKVGSPERPLSDLGLISYRSYWKEVLLRYL----HNFQGKE--ISIKEISQETAVNPVDIVS 557

  Fly   487 TLQNLNLINYYKGQYIV-----CINRVIIEQHRRAMDKRKIRIDSKCLHWTP 533
            |||.|.::.|:||:::|     .|:..|.::.:|:...:  .:|..||.|||
Human   558 TLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNK--TMDPSCLKWTP 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tip60	NP_572151.1	CBD_TIP60_like	27..90	CDD:350848	9/38 (24%)
		PLN00104	<255..533	CDD:215056	148/282 (52%)
KAT7	NP_008998.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..173		26/128 (20%)
		zf-C2HC	184..212	CDD:460240	4/27 (15%)
		PLN00104	<324..609	CDD:215056	151/292 (52%)