DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tip60 and KAT7

DIOPT Version :9

Sequence 1:NP_001259234.1 Gene:Tip60 / 31362 FlyBaseID:FBgn0026080 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_008998.1 Gene:KAT7 / 11143 HGNCID:17016 Length:611 Species:Homo sapiens


Alignment Length:572 Identity:198/572 - (34%)
Similarity:285/572 - (49%) Gaps:127/572 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 KRLDEWVNEEDLY-TRKV-------------QFPRRDGSQTGTSTGVTTPQRHHSLAGSVSRPTS 115
            :.|..:..||..| ||:|             ::|.|....:|:.|.............:.....|
Human    60 RNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDES 124

  Fly   116 PQHPGSGALAAIPQTPTGASGSVPPPAGI--PN-----SVAPPGTPSSGGELVNGNNLAAALQKR 173
            |           |:||||.:.|......|  ||     |:|...:...     :|::|:...::|
Human   125 P-----------PRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKD-----SGSDLSHRPKRR 173

  Fly   174 -------INRKRKNHGGSAHGH-----------------HSLTS--------------------- 193
                   .|.|....|.::.||                 |:|::                     
Human   174 RFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSH 238

  Fly   194 QQQQSHPHPTTPQTPTATPVHV----------TGDGLISGAANDDGDGSQD-GKTPTP------- 240
            :|..::.|.|..|.||...:..          ...||.........:..|. |.|..|       
Human   239 RQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTS 303

  Fly   241 -------RQSGSMVTH-------QDDVVTRMKNVEMIELGRHRIKPWYFSPYPQELCQMPCIYIC 291
                   |::.:..:.       |..:......::.|..||:.:..||.||||:|..::..:|:|
Human   304 EYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMC 368

  Fly   292 EFCLKYRKSRKCLERHLSKCNLRHPPGNEIYRKHTISFFEIDGRKNKVYAQNLCLLAKLFLDHKT 356
            ||||||.||:..|.||::||..:||||:|||||.:||.||:||:|||:|.|||||||||||||||
Human   369 EFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKT 433

  Fly   357 LYYDTDPFLFYVMTEFDSRGFHIVGYFSKEKESTEDYNVACILTMPPYQRKGYGKLLIEFSYELS 421
            ||||.:|||||||||.|:.|.|::|||||||.|..:|||:||||||.|.|:||||:||:|||.||
Human   434 LYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLS 498

  Fly   422 KFEGKTGSPEKPLSDLGLLSYRSYWAQTILEIFISQNPSTDGEKPTITINDICECTSIKKEDVIS 486
            |.|.|.||||:|||||||:||||||.:.:|...    .:..|::  |:|.:|.:.|::...|::|
Human   499 KVEEKVGSPERPLSDLGLISYRSYWKEVLLRYL----HNFQGKE--ISIKEISQETAVNPVDIVS 557

  Fly   487 TLQNLNLINYYKGQYIV-----CINRVIIEQHRRAMDKRKIRIDSKCLHWTP 533
            |||.|.::.|:||:::|     .|:..|.::.:|:...:  .:|..||.|||
Human   558 TLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNK--TMDPSCLKWTP 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tip60NP_001259234.1 Tudor-knot 23..78 CDD:288553 4/13 (31%)
Drf_FH1 84..>157 CDD:283903 17/79 (22%)
PHA01732 139..>196 CDD:222828 15/108 (14%)
NAT_SF 254..533 CDD:302625 148/283 (52%)
MOZ_SAS 316..500 CDD:280097 113/183 (62%)
KAT7NP_008998.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..173 26/128 (20%)
zf-C2HC 184..212 CDD:396216 4/27 (15%)
PLN00104 <324..609 CDD:215056 151/292 (52%)
acetyl-CoA binding. /evidence=ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAK 475..477 1/1 (100%)
WM-3835 inhibitor binding. /evidence=ECO:0000269|PubMed:31827282, ECO:0007744|PDB:6MAJ 483..488 3/4 (75%)
acetyl-CoA binding. /evidence=ECO:0000269|PubMed:28334966, ECO:0000269|PubMed:31827282, ECO:0007744|PDB:5GK9, ECO:0007744|PDB:6MAK 483..488 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5027
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D285390at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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