DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brn and B3GNT8

DIOPT Version :9

Sequence 1:	NP_476901.1	Gene:	brn / 31358	FlyBaseID:	FBgn0000221	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001372577.1	Gene:	B3GNT8 / 374907	HGNCID:	24139	Length:	397	Species:	Homo sapiens

Alignment Length:	278	Identity:	79/278 - (28%)
Similarity:	119/278 - (42%)	Gaps:	30/278 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GSGSASSGLDKFAYLRVPSFTAEVPVDQPARLTMLIKSAVGNSRRREAIRRTWGYEGRFSDVHLR 113
            |.||..|...          ..:||.     |.:.:||..|....|:|:|.|||...    ..:|
Human   134 GGGSQVSSCS----------DTDVPY-----LLLAVKSEPGRFAERQAVRETWGSPA----PGIR 179

  Fly   114 RVFLLGT-----AEDSEKDVAWESREHGDILQAEFTDAYFNNTLKTMLGMRWASDQFNRSEFYLF 173
            .:||||:     ..|.:..||||||.:.|:|..:|.|..||.|||.:|.:.|.........|.|.
Human   180 LLFLLGSPVGEAGPDLDSLVAWESRRYSDLLLWDFLDVPFNQTLKDLLLLAWLGRHCPTVSFVLR 244

  Fly   174 VDDDYYVSAKNVLKFLGRGRQSHQPELLFAGHVF-QTSPLRHKFSKWYVSLEEYPFDRWPPYVTA 237
            ..||.:|....:|..| |.........|:.|.|| |..|||.....:||. |.:....:|.|.:.
Human   245 AQDDAFVHTPALLAHL-RALPPASARSLYLGEVFTQAMPLRKPGGPFYVP-ESFFEGGYPAYASG 307

  Fly   238 GAFILSQKALRQLYAASVHLPLFRFDDVYLGIVALKAGISLQHCDDFRFHRPAYKGPD--SYSSV 300
            |.::::.:....|..|:..:..|.|:|||.|:.....|:..|....|....||.:..|  ::.::
Human   308 GGYVIAGRLAPWLLRAAARVAPFPFEDVYTGLCIRALGLVPQAHPGFLTAWPADRTADHCAFRNL 372

  Fly   301 IASHEFGDPEEMTRVWNE 318
            :.....| |:...|:|.:
Human   373 LLVRPLG-PQASIRLWKQ 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brn	NP_476901.1	Galactosyl_T	92..282	CDD:250845	61/195 (31%)
B3GNT8	NP_001372577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..58
B3GNT8	NP_001372577.1	Galactosyl_T	162..349	CDD:419759	60/192 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156978
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4482
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174158at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X41
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.800