Protein Alignment Xpac and XPA

DIOPT Version :10

• Sequence 1: NP_476866.1
• Gene: Xpac / 31357
• FlyBaseID: FBgn0004832
• Length: 296
• Species: Drosophila melanogaster
• Sequence 2: NP_000371.1
• Gene: XPA / 7507
• HGNCID: 12814
• Length: 273
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 126/296 - (42%)
• Similarity: 182/296 - (61%)
• Gaps: 23/296 - (7%)

  Fly     1 MSAEVSTNESAPPAEKKSKLTNAQKARIERNQAKAQKLREAKLVSHPFKELASNKEGGTHPEAAL 65
            |:|.......|...|:.::|..:.:|.|||.:.:|..||:|:|.:.|:...|          ||.
Human     1 MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATA----------AAA 55

  Fly    66 SQGSSVIKVQGTKYIDSGGGFLLEQPVMPTGVGPAGLNKSGEEAPPILDDAIAIPVQYEECLECG 130
            :.|.:.:|. ..|.||:||||:||:....    ...:.|...:..|:::      ..|..|.|||
Human    56 TGGMANVKA-APKIIDTGGGFILEEEEEE----EQKIGKVVHQPGPVME------FDYVICEECG 109

  Fly   131 DMFADSYLFNNFGHSVCDKCRDKDERYALITRTEAKAEYLLKDCDFDKREPKLRYISRKNPHNVR 195
            ..|.||||.|:|....||.|||.|:::.|||:||||.||||||||.:||||.|::|.:||||:.:
Human   110 KEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQ 174

  Fly   196 WGEMKLYLHLQIHQRALEVWGSEEELVRQHEAREDKREEGKARKYNKKMKQLRMEVRSSIYTKKT 260
            ||:|||||.|||.:|:||||||:|.|....|.|::.||:.|.:|::||:|:||..||||::.::|
Human   175 WGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRET 239

  Fly   261 HEVHEHEFGPDTYDEEEDTYTHTCITCPYSETYEKM 296
             .||:||:||:. :.|:|.|..||..|.:..|||||
Human   240 -IVHQHEYGPEE-NLEDDMYRKTCTMCGHELTYEKM 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpac	NP_476866.1	rad14	126..296	CDD:273164	92/169 (54%)
XPA	NP_000371.1	Interaction with CEP164 and required for UV resistance. /evidence=ECO:0000269|PubMed:19197159	4..97		28/107 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	26..47		9/20 (45%)
		rad14	105..273	CDD:273164	92/169 (54%)