Protein Alignment CG43689 and myt1a

DIOPT Version :10

• Sequence 1: NP_001259230.1
• Gene: CG43689 / 31353
• FlyBaseID: FBgn0263772
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_021329404.1
• Gene: myt1a / 557002
• ZFINID: ZDB-GENE-030131-3885
• Length: 1201
• Species: Danio rerio
• Alignment Length: 1260
• Identity: 272/1260 - (21%)
• Similarity: 415/1260 - (32%)
• Gaps: 393/1260 - (31%)

  Fly   407 LALHEQILKCPTPGCNGRGHVQPHRSVHRSLSGCPRAVRRSGGTSRRPGAAPLAAAAADLDKHEK 471
            |.|..|...||||||:|.|||....:.|||..|||.|.:|.           |..|..:|...:|
Zfish    60 LELVGQEYSCPTPGCDGLGHVSGKYARHRSALGCPLAKKRK-----------LQEAEENLPAPKK 113

  Fly   472 ELHPLDKLKLASNHYLNNNNSNCINNNSSKLSGSTTMPIIKSEYSPVASIKSEYNKSPMHSYLSG 536
            :  | :.||||.:... |.:|:..:...:|..|      ::||......:.....|||....::.
Zfish   114 K--P-NLLKLAMDDGF-NADSDTNSETETKDEG------VESEEDTADKVMEVKEKSPASEAMTE 168

  Fly   537 EAA--------------APAPAAPSSASAVQAPRSGSASGATAANGENNLHAPHLSRFVGLQSPP 587
            |::              :|.|       .::..:.           |.|:.:          :|.
Zfish   169 ESSQVNLEEKETPIRQTSPVP-------EIEIEKE-----------EANIES----------TPI 205

  Fly   588 HQPHLNPHGHHQQQQQQQQQQQQQQQQQQQQQQQQQHTLHQQRGPFIEGNDVPDPSANYHSEHQQ 652
            .|..::.....:.|..::.|.::::.:::.::..::..:.||    ::..|.|..:.      ::
Zfish   206 QQITMDTEAEEELQVAEEIQAREEEVEEEAEEITEEERVTQQ----LKETDEPVTTV------EE 260

  Fly   653 QQQQQQQQQQADERQQQYEQMRYAQSHVSVGPSGELMAPNGGELSPGTARSAYEAHPGHPHPHPG 717
            :::..::.::.:|..|...|...:......|..|::.....|||.   ..|..|...|.......
Zfish   261 EEEDDEEDEEGEEETQCLSQKNNSDHQYFSGDFGKMQTKETGELE---RDSEDEDEEGDEEEEEE 322

  Fly   718 HPHPHPPVSLSSLSSPAFTVDA----VTAASGAGF---------------ERYDPSGVCCPSNGQ 763
            .....|    |||.:|..||.|    |........               ||.|.|....|
Zfish   323 QSQVEP----SSLMAPVPTVSAQELDVMTHGNINLDHHLGEDEEEEEDEDERDDASDKDSP---- 379

  Fly   764 RATAATAATAAGASAAAAAYHYLPQTTDEMQAQQQKYLQEQQLMLAKAEHEELANGGQ-PLYPRP 827
                 |.....|:..           .:|.:.:::...:|::..:.:|:.::|.:..| ......
Zfish   380 -----TVVIELGSDG-----------EEEEEEEEEDDGEEEEEEIDEADDDDLDSMSQRSEVTDD 428

  Fly   828 MYHYDPTMGPLPPGFSAINLSVKMAAAQAAAAAAAYQNQQQQQQQQQQQQQHHQQQQQQQQQQQ- 891
            ...||.|.|         ||.:   ..||.|..|.......::....:||.:|....:..:...
Zfish   429 SETYDMTRG---------NLGL---LEQAIALKAEQTGHSSEESYSPEQQPYHSLDDRTSKVMDI 481

  Fly   892 QQQQQQHGKQSSSPAPNVSGVPAVDLSGSTSVT---------SSSPHGFNSP----ASH------ 937
            ..::..:||..|.........|.....|:..||         |..||....|    |.|
Zfish   482 AARRAYYGKDGSRLEKKEVKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKC 546

  Fly   938 -------------NQYTAQRMGNGSPQPGASPNIASPQVPSPQGQTLDLSVTRLPHSI------- 982
                         |:.| .|..:|.|...|..:.:..:...||...:|      |.|:
Zfish   547 PTPGCTGQGHVNSNRNT-HRSLSGCPIAAAGKHKSHDKQSQPQTSVID------PASVGSNSDRV 604

  Fly   983 ---------ITSPQYGA-------------------------------DGLVVGH---AQGFVSG 1004
                     :..||||:                               |..|.|.   |....:.
Zfish   605 LRPMCFVKQLEIPQYGSYRTNAMPATPRANLAKELEKYSKVSFDYASFDVQVFGKRMLAPKMPTS 669

  Fly  1005 ATGPLGPGNGGPPRSPQMEPVDFSGPPRPLGFGLVGHISGPRPYSRESTPDSGGSHYIET----- 1064
            .|.|....:...|::|        .|...|..|.....|.......:.|.|:..:|...|
Zfish   670 ETSPKAFKSILIPKAP--------SPSHSLSGGYTKSSSSSTSSGYDYTHDAEAAHMAATAILNL 726

  Fly  1065 ----YRDPSGYSPHP----GYGMVVQSD-----------------------------------YP 1086
                :..|...|..|    |..|.::.|                                   ..
Zfish   727 STRCWERPENLSTRPPDQAGKDMDIEVDENGTLDLSMKKPKREGVRSPDPSSSSSSSSQHHGVTS 791

  Fly  1087 PAGYHGY------GPAAYQCSN---------------PYATAVGPGG-----------YPTPV-S 1118
            |...|.|      ||..|..||               .||::.|...           ||..| :
Zfish   792 PHSSHTYKQEEWEGPLDYTKSNRQKEEEPEEVEYTTHSYASSDGEDDDGTQEGAEDRTYPGEVTT 856

  Fly  1119 GGYS---------------PSPATCYSMPPPQHIPQHDKSKDGLTGCSRSD---RNHLQSHSQEL 1165
            ..|.               |:|....|    .||..:..|...|:||..:|   |..:.:|:.||
Zfish   857 SSYKVKFQPKDLKKEILLCPTPGCDGS----GHITGNYASHRSLSGCPLADKSLRTLMAAHTAEL 917

  Fly  1166 KCPTPGCDGSGHVTGNYSSHRSLSGCPRANKP--KSKPR--DGQDSEPLRCPIPGCDGSGHSTGK 1226
            ||||||||||||:||||:|||||||||||.|.  |:.|.  |.:|||.::||:||||..||.:||
Zfish   918 KCPTPGCDGSGHITGNYASHRSLSGCPRAKKGGIKTTPTKDDKEDSELIKCPVPGCDSLGHISGK 982

  Fly  1227 FLSHRSASGCPIANRNKMRVLEAGGTVEQHKAAVAAATAMKFDACTTVGSQGIKKPKFDEVTMVY 1291
            :.:||||.|||:|.|.:...: ..||....||.....     ..|.|.|..|
Zfish   983 YATHRSAYGCPLAARRQKEGM-LNGTPFSWKAFKTEG-----PTCPTPGCDG------------- 1028

  Fly  1292 PKGYTGGSGLDIVMGGVGSSVGVGLGLNVGIGVTSSSSSSSSAGGNNNNSGSSNTVVTDKNPSGG 1356
             .|:..||.|                      ...|.|....|..|...:.........|.   .
Zfish  1029 -SGHANGSFL----------------------THRSLSGCPRASANKKRARFPGDDYISKK---F 1067

  Fly  1357 GASSGANGSDDLNTLEAEISELQRENARVESQMMRLKSDINAMESQLSTSDREAS---------- 1411
            .||...:..:|:..|..||:||...|:.:|:.|..|.:.|::||..|.:.:.|..
Zfish  1068 RASDVLDNDEDIKQLNKEINELNESNSEMEADMANLHTQISSMEKNLKSMEEENKLIEEKNEALF 1132

  Fly  1412 -PLSGHQQQQQRSSVALASPSGQSP 1435
             .|||..|...||...:..|..|.|
Zfish  1133 MELSGLSQALIRSLANIRLPQMQEP 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43689	NP_001259230.1	zf-C2HC	415..443	CDD:460240	16/27 (59%)
		zf-C2HC	1166..1194	CDD:460240	25/27 (93%)
		zf-C2HC	1211..1239	CDD:460240	17/27 (63%)
myt1a	XP_021329404.1	zf-C2HC	69..96	CDD:460240	16/26 (62%)
		zf-C2HC	501..527	CDD:460240	5/25 (20%)
		zf-C2HC	545..573	CDD:460240	5/28 (18%)
		MYT1	622..866	CDD:462489	37/251 (15%)
		zf-C2HC	875..902	CDD:460240	9/30 (30%)
		zf-C2HC	918..946	CDD:460240	25/27 (93%)
		zf-C2HC	967..995	CDD:460240	17/27 (63%)
		zf-C2HC	1020..1048	CDD:460240	10/63 (16%)
		COG4372	<1077..>1145	CDD:443500	19/67 (28%)