Protein Alignment CG43689 and St18

DIOPT Version :10

• Sequence 1: NP_001259230.1
• Gene: CG43689 / 31353
• FlyBaseID: FBgn0263772
• Length: 1706
• Species: Drosophila melanogaster
• Sequence 2: XP_030109815.1
• Gene: St18 / 240690
• MGIID: 2446700
• Length: 1052
• Species: Mus musculus
• Alignment Length: 1620
• Identity: 312/1620 - (19%)
• Similarity: 463/1620 - (28%)
• Gaps: 758/1620 - (46%)

  Fly     1 MALSKRPLTKDTPLSES--NGNHTNG----NDHETS----IKRRKRCSRDD-------DSSLINN 48
            :.:..|..:.|....||  |.|..:|    |||.|:    :|     |.|:       ||||
Mouse    64 LLMKPRHYSPDMGCKESPDNRNEDDGLLETNDHATADEIMVK-----SMDETLHLPAQDSSL--- 120

  Fly    49 NNNNNNNNNNNNNNNSNSNNNNLPQKKRKQGGQGHIADSPESPTCGSLPTPLAKSNTDADQDDET 113
                                    |||             :..||  .|..:.||.....:.:|:
Mouse   121 ------------------------QKK-------------DQYTC--YPELMVKSLVHLGKFEES 146

  Fly   114 LIRETQAALKSLSGSWPDSRGNLYRLQ-EQDE------------------NPPPFQNLFEEKQKY 159
              ...|...::|:||      ::..|: |.||                  :.|||.:..:.:...
Mouse   147 --ESVQTTCENLNGS------SIQSLKAESDEAHEGSMVHSDNGRDKVHHSQPPFCSSGDSESDS 203

  Fly   160 EAI----GNPSHAIQAQASSPNPNSTLFSRFHRQKENDQARLNAASGAGGVVHLEAQGRGKKTP- 219
            ::.    ||.|::.:...:...|.       |:...|.:..|.       |..::|:. .|..|
Mouse   204 DSAENGWGNGSNSSEDTDTHKGPK-------HKLTYNRKDLLE-------VPEIKAED-DKFIPC 253

  Fly   220 ----DEDQD--------------------PELEDTSSSASGQGVYTQAASAFKPPIDIIKRNYVA 260
                |.|.|                    ||:|:..|          .|:..:.|.::.|
Mouse   254 ENRCDSDTDGRDPQNSHMEPLVVKAQPSFPEVEEGES----------LATVTEEPAEVEK----- 303

  Fly   261 AAHAHYSAYNAAAAAESAAGLAYYGYAAAAAASQQQQQQQQQHQQQQHQQLSTAFDIASQLGEKQ 325
             |..:.|....|.|.::..|..::                     ..:::|...| :.....|::
Mouse   304 -AKGNLSLLEQAIALQAERGSVFH---------------------HTYKELDRFF-LDHLARERR 345

  Fly   326 RPKEPMADGKQYTILQPAGIGSRAASVMQDIASREGVVGVPLVATPPSTAAGSPAAAVPAAGPST 390
            :|:...|:|:|        |.:...|                 ..|....|..|.......|..|
Mouse   346 QPRVTDANGRQ--------IFTNKHS-----------------PRPERREAKCPIPGCDGTGHVT 385

  Fly   391 PSTPAPSYSPGSQNRV------LALHEQILKCPTPGCNGRGHVQPHRSVHRSLSGCPRAVRRSGG 449
            ...|......|..::|      ||:||.:||||||||.|||||..:|:.|||||||
Mouse   386 GLYPHHRSLSGCPHKVRVPLEILAMHENVLKCPTPGCTGRGHVNSNRNTHRSLSGC--------- 441

  Fly   450 TSRRPGAAPLAAAAADLDKHEKELHPLDKLKLASNHYLNNNNSNCINNNSSKLSGSTTMPIIKSE 514
                    |:|||              :||.:..
Mouse   442 --------PIAAA--------------EKLAMTQ------------------------------- 453

  Fly   515 YSPVASIKSEYNKSPMHSYLSGEAAAPAPAAPSSASAVQAPRSGSASGATAANGENNLHAPHLSR 579
                       :||.:.|..:|:.
Mouse   454 -----------DKSQLDSSQTGQC----------------------------------------- 466

  Fly   580 FVGLQSPPHQPHLNPHGHHQQQQQQQQQQQQQQQQQQQQQQQQQHTLHQQRGPFIEGNDVPDPSA 644
                   |.|.|                  :....:|.:...:.|.:...|.
Mouse   467 -------PEQAH------------------RVNLVKQIEFNFRSHAITSPRA------------- 493

  Fly   645 NYHSEHQQQQQQQQQQQQADERQQQYEQM--RYAQSHVSVGPSGELMAPNGGELSPGTARSAYEA 707
                             .|.:.|:::.::  .||.....|.....|:....|:.:|
Mouse   494 -----------------SASKEQEKFGKVPFDYASFDAQVFGKRPLLQTGQGQKAP--------- 532

  Fly   708 HPGHPHPHPGHPHPHPPVSLSSLSSPAFTVDAVTAASGAGFERYDPSGVCCPSNGQRATAATAAT 772
                  |.|...|...||..                         |:|:  ||.|....:...|:
Mouse   533 ------PFPESKHFSNPVKF-------------------------PNGL--PSAGAHTQSTVRAS 564

  Fly   773 AAGAS--------AAAAAYHYLP----QTTDEMQAQQQKYLQEQQLMLAKAEHEELANGGQPLYP 825
            :.|..        |||||...|.    :.||.:..      :.|.|....||.|...||...|..
Mouse   565 SYGHGQYSEDTHIAAAAAILNLSTRCREATDILSN------KPQSLRAKGAEIEVDENGTLDLSM 623

  Fly   826 RPMYHYD----PTMGP---LPPGFSAINLSVKMAAAQAAAAAAAYQNQQQQQQQQ---QQQQQHH 880
            :....:|    ||..|   ..|..|..|      |:.....||.||....|:...   ...:.|.
Mouse   624 KKNRIHDKSIPPTSSPTTITTPSSSPFN------ASSLLVNAAFYQALSDQEGWNVPINYSKSHG 682

  Fly   881 QQQQQQQQQQQQQQQQQHGKQSSSPAPNVSGVPAVDLSGSTSVTSSSPHGFNSPASHNQYTAQRM 945
            :.::::::               .|...:..:.....:|..|:.|
Mouse   683 KTEEEKEK---------------DPVNFLENLEEKKFAGEASIPS-------------------- 712

  Fly   946 GNGSPQPGASPNIASPQVPSPQGQTLDLSVTRLPHSIITSPQYGADGLVVGHAQGFVSGATGPLG 1010
                              |.|:..|.||.     ..:||.|..|.||
Mouse   713 ------------------PKPKLHTRDLK-----KELITCPTPGCDG------------------ 736

  Fly  1011 PGNGGPPRSPQMEPVDFSGPPRPLGFGLVGHISGPRPYSRESTPDSGGSHYIETYRDPSGYSPHP 1075
                                        .||::|                         .|:.|
Mouse   737 ----------------------------SGHVTG-------------------------NYASH- 747

  Fly  1076 GYGMVVQSDYPPAGYHGYGPAAYQCSNPYATAVGPGGYPTPVSGGYSPSPATCYSMPPPQHIPQH 1140
                                                   ..|||        |         |..
Mouse   748 ---------------------------------------RSVSG--------C---------PLA 756

  Fly  1141 DKSKDGLTGCSRSDRNHLQSHSQELKCPTPGCDGSGHVTGNYSSHRSLSGCPRANKP--KSKP-- 1201
            ||:...|          :.::|||||||||||||||||||||:|||||||||||.|.  |..|
Mouse   757 DKTLKSL----------MAANSQELKCPTPGCDGSGHVTGNYASHRSLSGCPRARKGGIKMTPTK 811

  Fly  1202 RDGQDSEPLRCPIPGCDGSGHSTGKFLSHRSASGCPI-ANRNKMRVLEAGGTVEQHKAAVAAATA 1265
            .:.:||| ||||:.||||.||.:||:.|||:|||||: |.|.|...|  .|.....|........
Mouse   812 EEKEDSE-LRCPVIGCDGQGHISGKYTSHRTASGCPLAAKRQKENPL--NGAPLSWKLNKQELPH 873

  Fly  1266 MKFDACTTVG------------------SQGIKKPKFDEVTMVYPKGYTGGSGLDIVMGGVGSSV 1312
            .....|..:|                  :|.|||.|..|..|......||
Mouse   874 CPLPGCNGLGHVNNVFVTHRSLSGCPLNAQAIKKVKVSEELMTIKLKATG--------------- 923

  Fly  1313 GVGLGLNVGIGVTSSSSSSSSAGGNNNNSGSSNTVVTDKNPSGGGASSGANGSDDLNTLEAEISE 1377
                                                            |.:|.:::..|:.||.|
Mouse   924 ------------------------------------------------GIDGDEEIRHLDEEIKE 940

  Fly  1378 LQRENARVESQMMRLKSDINAMESQLSTSDREASPLSGHQQQQQRSSVALASPSGQSPFASVSST 1442
            |...|.::|:.||:|::.|.:|||.|.|.:.|      ::..:|.:...|...:|.|. |.:||.
Mouse   941 LNESNLKIEADMMKLQTQITSMESNLKTIEEE------NKLIEQSNESLLKELAGLSQ-ALISSL 998

  Fly  1443 SGASSSVSGATTNSNNNNSSSGGGTTNANDLNHSISNL----APSSGS---NPNQAIEGV 1495
            :.......|.....|..        ...|.|....|||    :|...:   :..||::|:
Mouse   999 ADIQLPQMGPINEQNFE--------AYVNTLTDMYSNLEQDYSPECKALLESIKQAVKGI 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43689	NP_001259230.1	zf-C2HC	415..443	CDD:460240	20/27 (74%)
		zf-C2HC	1166..1194	CDD:460240	26/27 (96%)
		zf-C2HC	1211..1239	CDD:460240	19/28 (68%)
St18	XP_030109815.1	zf-C2HC	372..398	CDD:460240	5/25 (20%)
		zf-C2HC	416..444	CDD:460240	21/44 (48%)
		MYT1	487..720	CDD:462489	57/369 (15%)
		zf-C2HC	728..756	CDD:460240	15/155 (10%)
		zf-C2HC	772..800	CDD:460240	26/27 (96%)
		zf-C2HC	820..848	CDD:460240	19/27 (70%)
		zf-C2HC	874..900	CDD:460240	2/25 (8%)
		EnvC	895..>1050	CDD:443969	45/232 (19%)
		Atg16_CCD	<928..977	CDD:480640	17/54 (31%)