Protein Alignment CG6414 and CES2

DIOPT Version :9

• Sequence 1: NP_001303565.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 176/599 - (29%)
• Similarity: 265/599 - (44%)
• Gaps: 110/599 - (18%)

  Fly    12 VILLCICIQWSDGRNSQCLHVRLSHGGWLIGR--HLTTHNGRHMRAFMGVPYAEPPLDDLRFRPP 74
            ::||.:..|..|..:.    :|.:|.|.::|.  |:...|. .::.|:|:|:|:|||..|||.||
Human    17 LLLLLVRGQGQDSASP----IRTTHTGQVLGSLVHVKGANA-GVQTFLGIPFAKPPLGPLRFAPP 76

  Fly    75 VPKAPWEGERLAIKDAPICLQ-------------RDPFRRDMILEGSEDCLYLNVYTPERPRTNG 126
            .|...|.|.|.......:|||             ...|..|.:   |||||||::|||.......
Human    77 EPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSM---SEDCLYLSIYTPAHSHEGS 138

  Fly   127 SLPVMVWFHGGGWQCGSGISSFYGPDFLLD-HDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQ 190
            :||||||.|||.  ...|::|.|....|.. .::|:|...:|||.|||.||......||.|..||
Human   139 NLPVMVWIHGGA--LVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQ 201

  Fly   191 LEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAH 255
            :..|.||:.|||.|||:|:.||:|||||||.||:..::|..|:||.|..|.:||....|
Human   202 VAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLP------ 260

  Fly   256 KGVAAGRATKLAQIVGCGNAGEWPEK---LECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEP 317
             |:.|..|..::.:|...:|.:..:.   :.|||.|..|:|:|.        ..|....|.||
Human   261 -GLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAI--------NKPFKMIPGVV-- 314

  Fly   318 EHDGAFLTVAPRQAAKPHGLQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLN-Y 381
              ||.||...|::                    ||.:|....:|.::....::|..::|.|:. |
Human   315 --DGVFLPRHPQE--------------------LLASADFQPVPSIVGVNNNEFGWLIPKVMRIY 357

  Fly   382 DHHDDSVRQ----------TITQRIESFYFKSGHDY--DKANHQNL----TDLISDGWFVAGIDE 430
            |...:..|:          |:.....:|......:|  |..:.|.|    .::::|..||....:
Human   358 DTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQ 422

  Fly   431 YLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELFVSAVP-- 493
            ....:.|:   ||.|.|.|.|:     ....|..|.....|.|.:||.::|   |..|.....
Human   423 VAHFQCSR---APVYFYEFQHQ-----PSWLKNIRPPHMKADHGDELPFVF---RSFFGGNYIKF 476

  Fly   494 TQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENE 558
            |:::.:|...|:..|.:||:.||||...    ||:| |......::.:|..:.       .:...
Human   477 TEEEEQLSRKMMKYWANFARNGNPNGEG----LPHW-PLFDQEEQYLQLNLQP-------AVGRA 529

  Fly   559 LMQHRVDFWRDLQP 572
            |..||:.||:...|
Human   530 LKAHRLQFWKKALP 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	168/568 (30%)
		Aes	<116..>254	CDD:223730	61/138 (44%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	169/579 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.810