DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	185/615 - (30%)
Similarity:	283/615 - (46%)	Gaps:	113/615 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VILLCICIQWSDGRNS-QCLHVRLSHGGWLIGR--HL-TTHNGRHMRAFMGVPYAEPPLDDLRFR 72
            ::||.|.:|   |::| :...:|.:|.|.:.|:  |: .|..|.|  .|:|:|:|:||:..|||.
  Rat    17 LLLLLIHVQ---GQHSPESSPIRNTHIGQVRGKLDHVKDTKAGVH--TFLGIPFAKPPVGPLRFA 76

  Fly    73 PPVPKAPWEGERLAIKDAPICLQRDPFRRDMI-LEG-------------SEDCLYLNVYTPERPR 123
            ||....||.|.|.......:|||    ..|:| .||             ||||||||:|.|....
  Rat    77 PPEAPEPWSGVRDGTSQPAMCLQ----NLDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPAHAH 137

  Fly   124 TNGSLPVMVWFHGGGWQCGSGISSFYGPDFL-LDHDIVLVSANFRLGPLGFLSTETLDCPGNNGL 187
            ...:||||||.||||..  :|::|.|....| ::.|:|:|:..:|||.|||.||......||.|.
  Rat   138 EGSNLPVMVWIHGGGLM--TGMASMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDEHARGNWGY 200

  Fly   188 KDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPW-- 250
            .||:..|.||:.|||.|||:|:.||:|||||||..|:.|::|..|:||.|..|.:||....|:
  Rat   201 LDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPYLI 265

  Fly   251 AQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVV 315
            |..:..     .:|.:|::.|| .|.:....:.|||.|...:|:|         .:.::...|.|
  Rat   266 ADTSEM-----FSTMVAKVSGC-EAMDSEALVHCLRAKSEAEILA---------INKVVQMVPAV 315

  Fly   316 EPEHDGAFLTVAPRQAA-----KP-----------HGLQLPLMVGATAEEGLLKTAALLNLPQLL 364
            .   ||.||...|::..     :|           :|..:||::|.|.   ::|..:..||..:|
  Rat   316 V---DGEFLPRHPKELLASEDFRPVPSIIGVNNDEYGWTIPLVMGTTQ---MIKELSRENLQAIL 374

  Fly   365 AEFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGID 429
            .:..:|.  :||:..:     |.:.:.....||.         .|......|:|:.|..||....
  Rat   375 KKTTAQL--MLPLECS-----DLLMEEYMGDIED---------PKTLQAQFTELMEDFMFVIPAL 423

  Fly   430 EYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRELF-VSAVP 493
            :....:.|.   ||.|.|.|.|:     ....|..|.....|.|.:|:.::|  |...: :....
  Rat   424 QVAHFQCSH---APVYFYEFQHQ-----ITFLKDIRPPHVKADHGDEIPFVF--GYFFWDMKTDF 478

  Fly   494 TQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENE 558
            |:::..|...|:..|.:||:.||||...:|:    | |...:..::.:|.|:.       .:...
  Rat   479 TEEEKLLSRRMMKYWANFARHGNPNSEGLSY----W-PVMDHDQQYLQLDTQP-------AVGRA 531

  Fly   559 LMQHRVDFW-----RDLQPHLPASHAHNEL 583
            |...|:.||     :.:|....|...|.||
  Rat   532 LKARRLQFWTKTLPQKIQELKGAQDNHTEL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	171/567 (30%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	63/140 (45%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	172/575 (30%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	49/104 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810