back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and BCHE

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens

Alignment Length:	607	Identity:	187/607 - (30%)
Similarity:	276/607 - (45%)	Gaps:	115/607 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILLCICIQWSDGRNSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPK 77
            :|||:.|..|...:...:..:   .|.:.|.:||...|. :.||:|:|||:|||..|||:.|...
Human    17 LLLCMLIGKSHTEDDIIIATK---NGKVRGMNLTVFGGT-VTAFLGIPYAQPPLGRLRFKKPQSL 77

  Fly    78 APWEGERLAIKDAPICLQRDPFRRDMILEG-------------SEDCLYLNVYTPERPRTNGSLP 129
            ..|.....|.|.|..|.|    ..|....|             |||||||||:.|.....|.:
Human    78 TKWSDIWNATKYANSCCQ----NIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNAT-- 136

  Fly   130 VMVWFHGGGWQCGSGISSFYGPDFLLDHD-IVLVSANFRLGPLGFLSTE-TLDCPGNNGLKDQLE 192
            |::|.:|||:|.|:.....|...||...: :::||.|:|:|.||||:.. ..:.|||.||.||..
Human   137 VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQL 201

  Fly   193 VLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKG 257
            .|.||:.|||:|||:|.|||:||||||.|||:.|:||..|..|..|.|.|||::..|||..: ..
Human   202 ALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTS-LY 265

  Fly   258 VAAGRATKLAQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDF-DPM-IPFPPVVEPEHD 320
            .|..|...||::.||....| .|.::|||.|..::|:  |.:.||..: .|: :.|.|.|    |
Human   266 EARNRTLNLAKLTGCSRENE-TEIIKCLRNKDPQEIL--LNEAFVVPYGTPLSVNFGPTV----D 323

  Fly   321 GAFLTVAP------RQAAKPHGLQLPLMVGATAEEGLLKTAALL----------NLPQLLAEFKS 369
            |.|||..|      .|..|..     ::||...:||   ||.|:          |......||:.
Human   324 GDFLTDMPDILLELGQFKKTQ-----ILVGVNKDEG---TAFLVYGAPGFSKDNNSIITRKEFQE 380

  Fly   370 QFEQVLPVVLNYD------HHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGI 428
            ..:...|.|..:.      |:.|.|..   ||.|::            .:.|.|::.|..|:...
Human   381 GLKIFFPGVSEFGKESILFHYTDWVDD---QRPENY------------REALGDVVGDYNFICPA 430

  Fly   429 DEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLF--PIGRELFVSA 491
            .|:.:......:.|  :.|.|:|:.:       |....|:.|..|..|::::|  |:.|.    .
Human   431 LEFTKKFSEWGNNA--FFYYFEHRSS-------KLPWPEWMGVMHGYEIEFVFGLPLERR----D 482

  Fly   492 VPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPV------EFARLGTKMEDSA 550
            ..|:.:..|...::..|.:|||.||||.|.        :.::|:||      ::..|.|:..
Human   483 NYTKAEEILSRSIVKRWANFAKYGNPNETQ--------NNSTSWPVFKSTEQKYLTLNTEST--- 536

  Fly   551 SIFRLENELMQHRVDFWRDLQP 572
               |:..:|...:..||....|
Human   537 ---RIMTKLRAQQCRFWTSFFP 555

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.