DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and nlgn3b

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_005165239.1	Gene:	nlgn3b / 567415	ZFINID:	ZDB-GENE-060526-197	Length:	846	Species:	Danio rerio

Alignment Length:	603	Identity:	166/603 - (27%)
Similarity:	260/603 - (43%)	Gaps:	135/603 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQR-------------DPFRRDMIL-- 105
            ::|||||.||:.:.||.||...:.|.|.|.|.:..|:|.|.             ..:..|.:.
Zfish    73 YLGVPYAAPPVGEKRFMPPDAPSAWSGVRNATRFPPVCPQTVRNAVPDIMMPVWATYNMDTVATY 137

  Fly   106 --EGSEDCLYLNVYTP---------------ERPRTNG-------SLPVMVWFHGGGWQCGSG-- 144
              |.||||||:|:|.|               ||...:|       ..|||::.|||.:..|:|
Zfish   138 LQEQSEDCLYMNIYVPTQSGTKRTGDMSADTERTEDDGLRDSRDDPRPVMLFIHGGSYMEGTGNI 202

  Fly   145 ----ISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFG 205
                :.:.||       ::::::.|:|:|.||||||......||.||.||::.|.|:..||..||
Zfish   203 MDGSVLASYG-------NVIVITLNYRVGILGFLSTGDQAAKGNYGLLDQIQALRWINKNIGYFG 260

  Fly   206 GDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA---QPAHKGVAAGRATK-L 266
            |||..|||||...|.:.|:...||..|.||.||.|.|||:..:.|:   ||.       :.|: |
Zfish   261 GDPGRVTVFGSGIGASCVSLLTLSHHSEGLFHRAIIQSGSALSSWSVNYQPV-------KYTRLL 318

  Fly   267 AQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPM---IPFPPVVEPEHDGAFLTVAP 328
            |:.||| |..:..:.:.|::|:...::|..       :..|.   :.|.||:    ||..:...|
Zfish   319 AERVGC-NVLDTQDLVLCMQKRSYRELVEQ-------EIQPARFHVAFGPVI----DGDLIPDDP 371

  Fly   329 RQAAKPHG--LQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFE----QVLPVVLNYDHHDDS 387
             :.....|  |...:|:|....||......::. |:......|.|:    ..:..:..|....|:
Zfish   372 -EVLMEQGEFLNYDIMLGVNQGEGFRFVEGVVE-PEEGGVSGSDFDFTVSDFVDSLYGYPEGKDT 434

  Fly   388 VRQTITQRIESFYFKSGHDYD--KANHQNLTDLISDGWFV--AGIDEYLRLRMSQEDVAPTYVYL 448
            :|:||     .|.:....|.|  :...:.|..:.:|..:|  |.:...|..|..    :||:.|.
Zfish   435 LRETI-----KFMYTDWADRDNPETRRKTLVAMFTDHQWVEPAVVTADLHARYG----SPTFFYA 490

  Fly   449 FDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVP---TQKDLELRELMLH 506
            |.|...:..       :..:..:.|.:||.|:|.:    ..|||    |   ::.|:.|..:::.
Zfish   491 FYHHCQSPM-------KPPWADSAHGDELPYVFGVPLIGPTELF----PCNFSRNDIMLSAVVMT 544

  Fly   507 LWVSFAKTGNPN---PTNVSF-HLP-------NWSPASSYPVEFARLGTKMEDSASIFRLENELM 560
            .|.:|||||:||   |.:..| |..       .|:....:...:..:|.|.       |:.:...
Zfish   545 YWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVTWAKYGPHDQLYLHIGLKP-------RVRDHYR 602

  Fly   561 QHRVDFWRDLQPHLPASH 578
            ..:|.||:.|.|||...|
Zfish   603 ATKVAFWKHLVPHLYNLH 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	159/590 (27%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	59/168 (35%)
nlgn3b	XP_005165239.1	COesterase	40..609	CDD:278561	159/590 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810