DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and ces2b

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	578	Identity:	189/578 - (32%)
Similarity:	269/578 - (46%)	Gaps:	90/578 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VILLCICI--------QWSDGRNSQCLHVRLSHGGWLIGRHLTTHNGRH--MRAFMGVPYAEPPL 66
            |:.|||.|        :..||...|      ::.|.|.|..:.. .|:.  :.:::|:|:|:||:
Zfish     8 VLSLCILIAVTLQNSVKAEDGPILQ------TNSGALKGLQMKA-RGKDTVIHSYLGIPFAKPPV 65

  Fly    67 DDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFRRDMI---------LEGSEDCLYLNVYTPERP 122
            ..||..||.|...|||.|.|.|...:|||......|::         ::.||||||||||||.:|
Zfish    66 GPLRLAPPQPAEKWEGVRDATKQPLMCLQDRQLVEDLVANLSAKVDMVDSSEDCLYLNVYTPSKP 130

  Fly   123 RTNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGL 187
            ..|..||||||.||||:...|. |.|.|.......|:|:|...:|||.|||.||...:.|||.||
Zfish   131 GRNDKLPVMVWIHGGGFTTCSA-SLFDGHVLAAYQDVVVVVIQYRLGLLGFFSTGDENAPGNYGL 194

  Fly   188 KDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWAQ 252
            .||:..|.||:.||.||||||.|||:|||||||.||:.|:||..|..|.||.||:|||
Zfish   195 LDQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSLHVLSPLSANLFHRAIAESGT------- 252

  Fly   253 PAHKGVAAGRATKLAQIV----GCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPP 313
            .|.:.:.......:||.:    || :.....:.::||.:|...:|:....:      :|:..|..
Zfish   253 AAMEAIMNVNPLPIAQAIGNASGC-DISSTKKIVDCLMQKSEVEILKITME------NPLFRFGV 310

  Fly   314 VVEPEHDGAFLTVAPRQAAKPHGLQ----LPLMVGATAEE-GLLKTAALLNLPQLLAEFKSQFEQ 373
            .:    ||.||   ||.||:....|    :|||.|.|.:| |.:....||. |..:...  ..|.
Zfish   311 TI----DGQFL---PRPAAELFQSQQFNKVPLMTGVTDDEIGFVLPNYLLP-PDWINGL--DLES 365

  Fly   374 VLPV--VLNYDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDEYLRLRM 436
            :||:  |.|....|.||.:.:...    |..:..|..:. .....:::.|  |:..|........
Zfish   366 ILPLLTVFNPALQDQSVLELLLNE----YLGTSPDRIRI-RDGFREMLGD--FMFNIPARQTASY 423

  Fly   437 SQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLF-------PIGRELFVSAVPT 494
            .::..||.|||.|.|.     ..:.:..|..|.|:.|.:|:.::|       |||   ....:..
Zfish   424 HRDAGAPVYVYEFRHP-----PSVLQRKRPSFSGSDHGDEIVFVFGYCFSEGPIG---MAENLSD 480

  Fly   495 QKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASI 552
            ::| ||....:..|.:||.|||||...    |.:| |......|:..:|...:.|..:
Zfish   481 EED-ELCRTTMAYWGNFAHTGNPNGPG----LTSW-PEFGDEAEYLSIGLDPKASTDL 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	181/546 (33%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	73/137 (53%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	184/559 (33%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810