DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	603	Identity:	176/603 - (29%)
Similarity:	270/603 - (44%)	Gaps:	129/603 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ--RDPF-RRDM-------------- 103
            ::|:|||.||..:.||:||.|...|.|.|.|.:.||:|.|  .|.| ..||
Zfish    70 YLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFLEDRFLLNDMLPVWFTANLDTVVT 134

  Fly   104 -ILEGSEDCLYLNVYTPERP---------------------RTNGSLPVMVWFHGGGWQCGSG-- 144
             :.:.||||||||:|.|...                     ..||..||||:.|||.:..|:|
Zfish   135 YVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGNM 199

  Fly   145 ----ISSFYGPDFLLDHDIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFG 205
                |.:.||       ::::|:.|:|||.||||||......||.||.||::.|.|::.||.:|.
Zfish   200 IDGSILASYG-------NVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFK 257

  Fly   206 GDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA---QPAHKGVAAGRATK-L 266
            |||..||:||..||.:.|:...||..|..|..:.|.||||..:.||   |||       :.|: |
Zfish   258 GDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIQSGTALSSWAVNYQPA-------KYTRIL 315

  Fly   267 AQIVGCGNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPPVVEPEHDGAFLTVAPRQA 331
            |:.||| |..:..:.:|||:.|..::::    :.::......|.|.||:    ||..:...| |.
Zfish   316 AEKVGC-NMLDSIDLVECLQNKNYKELI----EQYITQAKYHIAFGPVI----DGDVIPDDP-QI 370

  Fly   332 AKPHG--LQLPLMVGATAEEGLLKTAALLNLPQLLA--EFKSQFEQVLPVVLNYDHHDDSVRQTI 392
            ....|  |...:|:|....||......:::....::  :|.......:..:..|....|::|:||
Zfish   371 LMEQGEFLNYDIMLGVNQGEGFKFVDGIVDSEDGVSANDFDFAVSDFVDHLYGYPEGKDTLRETI 435

  Fly   393 TQRIESFYFKSGHDYD--KANHQNLTDLISDGWFVAGIDEYLRLRMSQEDV-----APTYVYLFD 450
                 .|.:....|.:  :...:.|..|.:|..:||.       .::..|:     :|||.|.|.
Zfish   436 -----KFMYTDWADKENPETRRKTLVALFTDHQWVAP-------AVATADLHAQYGSPTYFYAFY 488

  Fly   451 HKGAASFTEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVPTQKDLELRELMLHLWVSF 511
            |...:..       :..:..:.|.:|:.|:|.|    ..:|| :...::.|:.|..:::..|.:|
Zfish   489 HHCQSEM-------KPSWSDSAHGDEVPYVFGIPMLGPTDLF-NCNFSKNDVMLSAVVMTYWTNF 545

  Fly   512 AKTGNPN---PTNVSF-HL-PN------WSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVD 565
            ||||:||   |.:..| |. ||      ||..:.....:..:|.|.       |:.:.....:|.
Zfish   546 AKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-------RVRDHYRATKVA 603

  Fly   566 FWRDLQPHLPASHAHNEL 583
            ||.:|.|||   |..|||
Zfish   604 FWLELVPHL---HNINEL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	166/585 (28%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	60/167 (36%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	166/585 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810