DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6414 and NLGN3

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	659	Identity:	182/659 - (27%)
Similarity:	267/659 - (40%)	Gaps:	192/659 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LTTHNGRHMRA--------------FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ 95
            :.||.|:...|              ::|||||.||:.:.||.||.|...|.|.|.|....|:|.|
Human    44 VNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQ 108

  Fly    96 RDP-----------FRRDM------ILEGSEDCLYLNVYTP------------------------ 119
            ...           |..::      |.|.:|||||||||.|
Human   109 NIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGG 173

  Fly   120 ------------------ERPRTNGSLPVMVWFHGGGWQCGSG------ISSFYGPDFLLDHDIV 160
                              |..|.:|:.||||:.|||.:..|:|      |.:.||       :::
Human   174 SGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVI 231

  Fly   161 LVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTY 225
            :::.|:|:|.||||||......||.||.||::.|.||..|||.|||||..:||||...|.:.|:.
Human   232 VITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSL 296

  Fly   226 HMLSEKSRGLLHRGIAQSGTYFNPWA---QPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRK 287
            ..||..|.||..|.|.|||:..:.||   ||..      ..:.||..||| |..:..:.::|||:
Human   297 LTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVK------YTSLLADKVGC-NVLDTVDMVDCLRQ 354

  Fly   288 KPAEDIVASLYDMFVWDFDPM---IPFPPVV-------EPE---HDGAFLTVAPRQAAKPHGLQL 339
            |.|:::|..       |..|.   :.|.||:       :||   ..|.|             |..
Human   355 KSAKELVEQ-------DIQPARYHVAFGPVIDGDVIPDDPEILMEQGEF-------------LNY 399

  Fly   340 PLMVGATAEEGLLKTAALLNLPQLLA--EFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFK 402
            .:|:|....|||.....:::....::  :|.......:..:..|....|::|:||     .|.:.
Human   400 DIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETI-----KFMYT 459

  Fly   403 SGHDYD--KANHQNLTDLISDGWFV--AGIDEYLRLRMSQEDVAPTYVYLFDH------KGAASF 457
            ...|.|  :...:.|..|.:|..:|  :.:...|..|..    :|||.|.|.|      |.|.|
Human   460 DWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG----SPTYFYAFYHHCQSLMKPAWS- 519

  Fly   458 TEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVP---TQKDLELRELMLHLWVSFAKTG 515
                        .|.|.:|:.|:|.:    ..:||    |   ::.|:.|..:::..|.:|||||
Human   520 ------------DAAHGDEVPYVFGVPMVGPTDLF----PCNFSKNDVMLSAVVMTYWTNFAKTG 568

  Fly   516 NPN---PTNVSF-HLP-------NWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRD 569
            :||   |.:..| |..       .||..:.....:..:|.|.       |:.:.....:|.||:.
Human   569 DPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKP-------RVRDHYRATKVAFWKH 626

  Fly   570 LQPHLPASH 578
            |.|||...|
Human   627 LVPHLYNLH 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	175/646 (27%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	63/188 (34%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	175/646 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		1/24 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810