Protein Alignment CG6414 and ACHE

DIOPT Version :9

• Sequence 1: NP_001303565.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 206/619 - (33%)
• Similarity: 288/619 - (46%)
• Gaps: 124/619 - (20%)

  Fly    15 LCICIQW-------SDGRNSQCLHVRLSHGGWLIGRHLTTHNGRHMRAFMGVPYAEPPLDDLRFR 72
            |.:.:.|       ::||....|.|.: .||.|.|..|.|..| .:.||:|:|:||||:...||.
Human    84 LLLLLLWLLGGGVGAEGREDAELLVTV-RGGRLRGIRLKTPGG-PVSAFLGIPFAEPPMGPRRFL 146

  Fly    73 PPVPKAPWEGERLAIKDAPICLQR--------------DPFRRDMILEGSEDCLYLNVYTPERPR 123
            ||.||.||.|...|.....:|.|.              :|.|     |.|||||||||:|| .||
Human   147 PPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNR-----ELSEDCLYLNVWTP-YPR 205

  Fly   124 TNGSLPVMVWFHGGGWQCGSGISSFYGPDFLLDHD-IVLVSANFRLGPLGFLSTE-TLDCPGNNG 186
            .....||:||.:|||:..|:.....|...||:..: .||||.|:|:|..|||:.. :.:.|||.|
Human   206 PTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVG 270

  Fly   187 LKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA 251
            |.||...|.||:.|:|:|||||.|||:||||||.|||..|:||..||||.||.:.|||....|||
Human   271 LLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA 335

  Fly   252 QPAHKGVAAGRATKLAQIVGC---GNAGEWPEKLECLRKKPAEDIVASLYDMFVWDFDPMIPFPP 313
             ....|.|..|||:||.:|||   |..|...|.:.|||.:||:.:|...:.:...:......|.|
Human   336 -TVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVP 399

  Fly   314 VVEPEHDGAFLTVAPR---QAAKPHGLQLPLMVGATAEEG---LLKTA--------ALLNLPQLL 364
            ||    ||.||:..|.   .|...||||  ::||...:||   |:..|        :|::..:.|
Human   400 VV----DGDFLSDTPEALINAGDFHGLQ--VLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFL 458

  Fly   365 AEFKSQFEQVL-----PVVLNYD---HHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISD 421
            |..:....||.     .|||:|.   |.:|..|.                     .:.|:|::.|
Human   459 AGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARL---------------------REALSDVVGD 502

  Fly   422 GWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLFPIGRE 486
            ...|..:.: |..|::.:. |..|.|:|:|:.:.....:       :.|..|..|::::|  |..
Human   503 HNVVCPVAQ-LAGRLAAQG-ARVYAYVFEHRASTLSWPL-------WMGVPHGYEIEFIF--GIP 556

  Fly   487 LFVSAVPTQKDLELRELMLHLWVSFAKTGNPN-PTNVSFHLPNWSP----ASSY------PVEFA 540
            |..|...|.::....:.::..|.:||:||:|| |.:..  .|.|.|    |..|      |:| .
Human   557 LDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPK--APQWPPYTAGAQQYVSLDLRPLE-V 618

  Fly   541 RLGTKMEDSASIFRLENELMQHRVDFWRDLQPHL 574
            |.|.:.:..|               ||....|.|
Human   619 RRGLRAQACA---------------FWNRFLPKL 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	196/582 (34%)
		Aes	<116..>254	CDD:223730	70/139 (50%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	198/590 (34%)
		AChE_tetra	645..678	CDD:400834

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910