DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and CG10175

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	203/569 - (35%)
Similarity:	293/569 - (51%)	Gaps:	61/569 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GWLIGRHLTTHNGRH--MRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQRDPFR 100
            |.:.||:....:|..  ..:|.|:.|..||....|||...|:.||.|.|.|.::...|    | .
  Fly   161 GKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSC----P-H 220

  Fly   101 RDMILE---GSEDCLYLNVYTPERPRTNGS-----LPVMVWFHGGGWQCGSGISSFYGPDFLLDH 157
            ::|||:   |.||||::||:|.:.|:.:.|     ||||||.||||:..|||.|..||||:|:..
  Fly   221 KNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVAE 285

  Fly   158 DIVLVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGAS 222
            |||||:.|:|||||||| |...|.|||.|||||:..|.|||.|||:||||||.||:||||||.:|
  Fly   286 DIVLVTLNYRLGPLGFL-TAGPDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASS 349

  Fly   223 VTYHMLSEKSRGLLHRGIAQSGTYFNPWAQPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRK 287
            |...:||.:::||.||.|:|||:..|||:..|.   ::.||.:||..:|...|.:..:.|:.||:
  Fly   350 VQLLLLSSQAKGLFHRAISQSGSALNPWSMSAS---SSQRAARLAANLGYVGANKTEDILDFLRR 411

  Fly   288 KPAEDIVASLYDMFVWDFDPM----IPFPPVV----------EPEHDGAFLTVAPRQA--AKPHG 336
            .||..:|.:.......: |..    :||.|||          |..::..|||..|...  ::...
  Fly   412 VPAMKLVEAAPTTITAE-DQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFN 475

  Fly   337 LQLPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQVLPVVLNY-DHHDDSVRQTITQRIESFY 400
            ..:..|.|....|.:|....|...||||:..::.|.:::|..||. :.||     .:|:.|.|||
  Fly   476 SDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHD-----RVTREIRSFY 535

  Fly   401 FKSGH----DYDKANHQNLTDLISDGWFVAGIDEYLRLRMSQEDVAPTYVYLFDHKGAASFTEIF 461
            ..|.|    ..|:     :..|::|..|:.||....| ..::...||.|:|.|...|:....:..
  Fly   536 LGSKHVGIESVDE-----MIALLTDLMFLQGIRRTAR-NHAKFGNAPVYMYRFSFDGSLGLYKRM 594

  Fly   462 KGGRNEFYGACHAEELQYLFPIGRELF-VSAVPTQKDLELRELMLHLWVSFAKTGNPNPTNVSFH 525
            .|....  |.||.:||.|||..|  .| :|..|...:::::..|:.:|.:|||.|:|.|.:....
  Fly   595 LGIPRP--GVCHGDELGYLFKFG--FFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPM 655

  Fly   526 L-PNWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRDLQPH 573
            | ..|:|..  |.........|:.||:: .::......|..||.::..|
  Fly   656 LTTKWAPID--PTNVMNSLNYMDISANL-AMKTNPEPERQRFWDEMYQH 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	200/561 (36%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	83/142 (58%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	200/561 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I1491
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.860