DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6414 and Ace

DIOPT Version :9

Sequence 1:	NP_001303565.1	Gene:	CG6414 / 31352	FlyBaseID:	FBgn0029690	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	606	Identity:	172/606 - (28%)
Similarity:	263/606 - (43%)	Gaps:	128/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GRHLTTHNGRHMRAFMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQR-----DPFRR 101
            ||.:|. .||.:..:.|:|||:||::|||||.|||..||.|...|.:.:..|:|.     ..|..
  Fly    54 GRSVTV-QGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATRLSATCVQERYEYFPGFSG 117

  Fly   102 DMI----LEGSEDCLYLNVYTPERPR--------------------------------TNGSLPV 130
            :.|    ...||||||:||:.|.:.|                                ||| ||:
  Fly   118 EEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNG-LPI 181

  Fly   131 MVWFHGGGWQCGSGISSFYGPDFLLD-HDIVLVSANFRLGPLGFL-------STETLDCPGNNGL 187
            ::|.:|||:..||.....|..|.:.. .::::.|..:|:|..|||       |....:.|||.||
  Fly   182 LIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGL 246

  Fly   188 KDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTYHMLSEKSRGLLHRGIAQSGTYFNPWA- 251
            .||...:.|::.|..:|||:|..:|:||||||.:||...::|..:|||:.||:.||||...||:
  Fly   247 WDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSH 311

  Fly   252 QPAHKGVAAGRATKLAQIVGCGNAGEWPEK----LECLRKKPAEDIVASLYDMFVWDFDPMIPFP 312
            ..:.|.|..|:|  |.....| ||......    :.|:|...|:.|....::    .:..::.||
  Fly   312 MTSEKAVEIGKA--LINDCNC-NASMLKTNPAHVMSCMRSVDAKTISVQQWN----SYSGILSFP 369

  Fly   313 PVVEPEHDGAFLTVAPRQAAKPHGLQ-LPLMVGATAEEGLLKTAALLNLPQLLAEFKSQFEQ--- 373
            ..  |..|||||...|....|...|: ..:::|...:||..         .||.:|...|::
  Fly   370 SA--PTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTY---------FLLYDFIDYFDKDDA 423

  Fly   374 -VLP-----VVLN--YDHHDDSVRQTITQRIESFYFKSGHDYDKANHQNLTDLISDGWFVAGIDE 430
             .||     .::|  :.....:.|:.|..:..|:....|:.    |.|.:...:.|.:|....:|
  Fly   424 TALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQ----NQQQIGRAVGDHFFTCPTNE 484

  Fly   431 YLRLRMSQEDVAPTYVYLFDHKGAASFTEIFKGGRNEFYGACHAEELQYLF--PIGRELFVSAVP 493
            |  .:...|..|..:.|.|.|:.:.|..       .|:.|..|.:|::|.|  |:...|....|
  Fly   485 Y--AQALAERGASVHYYYFTHRTSTSLW-------GEWMGVLHGDEIEYFFGQPLNNSLQYRPV- 539

  Fly   494 TQKDLELRELMLHLWVSFAKTGNPNPTNVSFHLPNWSPASSYPVEFARLGTKMEDSASIFRLENE 558
               :.||.:.||...:.|||||||......:  ||:|...  ||.:            ||..:::
  Fly   540 ---ERELGKRMLSAVIEFAKTGNPAQDGEEW--PNFSKED--PVYY------------IFSTDDK 585

  Fly   559 L-------MQHRVDFWRDLQP 572
            :       :..|..||.|..|
  Fly   586 IEKLARGPLAARCSFWNDYLP 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6414	NP_001303565.1	COesterase	36..567	CDD:278561	168/599 (28%)
CG6414	NP_001303565.1	Aes	<116..>254	CDD:223730	57/178 (32%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	168/599 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.810